SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qcw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 375
ASN A 157
GLY A 374
VAL A 387
 None
None
FNS  A 570 (-3.2A)
None
 0.84A 1dbbH-1qcwA:
undetectable
1dbbL-1qcwA:
undetectable		 1dbbH-1qcwA:
19.18
1dbbL-1qcwA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 384
GLN A 352
LYS A 349
VAL A 368
 None
None
FNS  A 570 (-2.7A)
None
 1.17A 1l2iB-1qcwA:
0.0		 1l2iB-1qcwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 353
ILE A 358
ILE A 394
GLU A 390
 None
 0.81A 1oniD-1qcwA:
undetectable
1oniF-1qcwA:
undetectable		 1oniD-1qcwA:
16.26
1oniF-1qcwA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 127
TYR A 126
GLU A 457
 None
 0.78A 1vm1A-1qcwA:
undetectable		 1vm1A-1qcwA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 454
PRO A 191
LEU A 422
ALA A 421
 None
 0.98A 2vcvB-1qcwA:
undetectable		 2vcvB-1qcwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FNS  A 570 (-3.5A)
None
None
None
None
 1.15A 3fhjA-1qcwA:
undetectable		 3fhjA-1qcwA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FNS  A 570 (-3.5A)
None
None
None
None
 1.15A 3fhjB-1qcwA:
undetectable		 3fhjB-1qcwA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FNS  A 570 (-3.5A)
None
None
None
None
 1.14A 3fhjC-1qcwA:
undetectable		 3fhjC-1qcwA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FNS  A 570 (-3.5A)
None
None
None
None
 1.15A 3fhjD-1qcwA:
undetectable		 3fhjD-1qcwA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FNS  A 570 (-3.5A)
None
None
None
None
 1.14A 3fhjE-1qcwA:
undetectable		 3fhjE-1qcwA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FNS  A 570 (-3.5A)
None
None
None
None
 1.15A 3fhjF-1qcwA:
undetectable		 3fhjF-1qcwA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 281
ILE A 346
MET A 183
ARG A 353
 None
 1.14A 3mssA-1qcwA:
undetectable		 3mssA-1qcwA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 281
ILE A 346
MET A 183
ARG A 353
 None
 1.20A 3oezA-1qcwA:
0.0		 3oezA-1qcwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 154
ARG A 433
GLU A 129
 None
FNS  A 570 (-4.1A)
None
 1.14A 3qf1A-1qcwA:
0.0		 3qf1A-1qcwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 7 THR A 153
GLY A 374
ASN A 372
GLY A 287
 None
FNS  A 570 (-3.2A)
None
None
 0.84A 3tajA-1qcwA:
undetectable		 3tajA-1qcwA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 8 THR A 137
TYR A 437
ARG A 108
LEU A 112
 None
 1.08A 3wipG-1qcwA:
0.0
3wipH-1qcwA:
0.0		 3wipG-1qcwA:
20.90
3wipH-1qcwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 108
LEU A 112
THR A 137
TYR A 437
 None
 1.11A 3wipF-1qcwA:
undetectable
3wipJ-1qcwA:
undetectable		 3wipF-1qcwA:
20.90
3wipJ-1qcwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 251
THR A 229
GLU A 236
 None
 0.80A 4df3A-1qcwA:
0.3		 4df3A-1qcwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 251
THR A 229
GLU A 236
 None
 0.81A 4df3B-1qcwA:
0.3		 4df3B-1qcwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 6 THR A 153
GLY A 374
ASN A 372
GLY A 287
 None
FNS  A 570 (-3.2A)
None
None
 0.86A 4fjpA-1qcwA:
undetectable		 4fjpA-1qcwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 190
ILE A 451
LEU A 454
ARG A 455
 None
 0.87A 4mghA-1qcwA:
undetectable		 4mghA-1qcwA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 230
LEU A 265
MET A 226
VAL A 274
 None
 1.15A 4okbA-1qcwA:
0.0		 4okbA-1qcwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 157
ASP A 282
GLY A 350
 None
 0.61A 5fctB-1qcwA:
undetectable		 5fctB-1qcwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 164
MET A 462
ASP A 417
 None
 0.82A 5h2uA-1qcwA:
undetectable		 5h2uA-1qcwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 410
GLY A 411
ALA A 160
ASN A 372
GLY A 375
 FNS  A 570 (-3.5A)
FNS  A 570 (-4.0A)
None
None
None
 0.98A 5kb5A-1qcwA:
undetectable		 5kb5A-1qcwA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 432
VAL A 418
THR A 416
ALA A 450
LEU A 454
 FNS  A 570 (-3.4A)
None
None
None
None
 0.96A 5kocA-1qcwA:
undetectable		 5kocA-1qcwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 412
ARG A 413
PRO A 434
GLY A 432
 None
FNS  A 570 (-3.3A)
None
FNS  A 570 (-3.4A)
 0.95A 5x80A-1qcwA:
0.0
5x80B-1qcwA:
0.2		 5x80A-1qcwA:
17.75
5x80B-1qcwA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 412
ARG A 413
PRO A 434
GLY A 432
 None
FNS  A 570 (-3.3A)
None
FNS  A 570 (-3.4A)
 1.01A 5x80C-1qcwA:
undetectable
5x80D-1qcwA:
0.5		 5x80C-1qcwA:
17.75
5x80D-1qcwA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 5 PRO A 434
GLY A 432
VAL A 412
ARG A 413
 None
FNS  A 570 (-3.4A)
None
FNS  A 570 (-3.3A)
 0.99A 5x80C-1qcwA:
0.0
5x80D-1qcwA:
0.0		 5x80C-1qcwA:
17.75
5x80D-1qcwA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 185
LEU A 184
THR A 181
VAL A 188
 None
 0.84A 6czmD-1qcwA:
undetectable
6czmF-1qcwA:
undetectable		 6czmD-1qcwA:
24.03
6czmF-1qcwA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 369
LEU A 370
SER A 371
GLY A 428
GLY A 432
 None
None
FNS  A 570 (-3.6A)
None
FNS  A 570 (-3.4A)
 1.14A 6eu9B-1qcwA:
0.0		 6eu9B-1qcwA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 227
GLN A 252
THR A 280
VAL A 281
 None
FNS  A 570 (-3.3A)
FNS  A 570 (-2.8A)
None
 1.05A 6fbvC-1qcwA:
undetectable		 6fbvC-1qcwA:
16.58