SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qcx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		5 / 9 VAL A 223
VAL A 214
LEU A 216
ILE A 166
LEU A 225
 None
 0.99A 1eqgA-1qcxA:
undetectable		 1eqgA-1qcxA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		5 / 11 VAL A 223
VAL A 214
LEU A 216
ILE A 166
LEU A 225
 None
 1.02A 1eqgB-1qcxA:
undetectable		 1eqgB-1qcxA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		5 / 12 VAL A 223
VAL A 214
LEU A 216
ILE A 166
LEU A 225
 None
 1.01A 1eqhA-1qcxA:
undetectable		 1eqhA-1qcxA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		5 / 11 PHE A  49
ILE A 121
GLY A 123
PHE A  51
ALA A 172
 None
 1.39A 1ju6A-1qcxA:
undetectable		 1ju6A-1qcxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		3 / 3 ARG A 236
VAL A 150
TRP A 151
 None
 1.19A 1zviA-1qcxA:
undetectable		 1zviA-1qcxA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		3 / 3 ASP A 217
ASP A 159
ASN A 243
 None
 0.70A 2bm9D-1qcxA:
undetectable		 2bm9D-1qcxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		5 / 11 THR A 170
THR A 171
THR A 143
ALA A 141
GLY A 198
 None
 1.17A 2f162-1qcxA:
undetectable		 2f162-1qcxA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		4 / 7 ALA A 271
ASN A 274
PHE A 276
LEU A 246
 None
 0.89A 2hzqA-1qcxA:
undetectable		 2hzqA-1qcxA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		4 / 7 VAL A 223
ASN A 243
GLY A 242
VAL A 240
 None
 0.91A 2y05A-1qcxA:
undetectable
2y05B-1qcxA:
undetectable		 2y05A-1qcxA:
22.34
2y05B-1qcxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		4 / 7 LEU A  31
LEU A  35
PRO A 103
ILE A 104
 None
 0.91A 3s56B-1qcxA:
undetectable		 3s56B-1qcxA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		3 / 3 LYS A 359
ARG A 199
LEU A 195
 None
 1.33A 3v4tE-1qcxA:
undetectable		 3v4tE-1qcxA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		3 / 3 ALA A 155
GLN A 357
GLY A 358
 None
 0.49A 4odoC-1qcxA:
undetectable		 4odoC-1qcxA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		4 / 5 GLN A  71
SER A 203
ASP A 257
ASP A 278
 None
 1.15A 4qtuB-1qcxA:
undetectable		 4qtuB-1qcxA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		4 / 5 GLN A  71
SER A 203
ASP A 257
ASP A 278
 None
 1.13A 4qtuD-1qcxA:
undetectable		 4qtuD-1qcxA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		4 / 7 PHE A 261
ALA A 248
ILE A 191
LEU A 216
 None
 1.07A 4uymB-1qcxA:
0.0		 4uymB-1qcxA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		5 / 12 THR A  28
ASP A  29
LEU A 126
ILE A 145
GLY A 100
 None
 0.93A 4xi3B-1qcxA:
undetectable		 4xi3B-1qcxA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		4 / 5 GLY A 213
ARG A 236
GLY A 235
GLU A 262
 None
 1.00A 4z2eB-1qcxA:
undetectable
4z2eC-1qcxA:
undetectable		 4z2eB-1qcxA:
20.32
4z2eC-1qcxA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		5 / 10 ILE A 140
ILE A 121
VAL A 169
THR A 171
ILE A 156
 None
 1.23A 5lg3F-1qcxA:
undetectable		 5lg3F-1qcxA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		5 / 10 ILE A 140
ILE A 121
VAL A 169
THR A 171
ILE A 156
 None
 1.25A 5lg3G-1qcxA:
undetectable		 5lg3G-1qcxA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		5 / 10 ILE A 140
ILE A 121
VAL A 169
THR A 171
ILE A 156
 None
 1.23A 5lg3H-1qcxA:
undetectable		 5lg3H-1qcxA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		5 / 12 LEU A 291
ASP A 326
ILE A 263
GLY A 289
SER A 325
 None
 1.00A 5twjC-1qcxA:
undetectable		 5twjC-1qcxA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		5 / 12 PHE A 230
LEU A 216
ILE A 166
ILE A 174
ALA A 172
 None
 1.19A 5vc0A-1qcxA:
0.0		 5vc0A-1qcxA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		4 / 7 SER A 294
PHE A 316
PRO A 344
ILE A 347
 None
 1.23A 5vkqC-1qcxA:
undetectable
5vkqD-1qcxA:
undetectable		 5vkqC-1qcxA:
12.66
5vkqD-1qcxA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		5 / 12 LEU A  45
ILE A 140
PHE A  51
GLY A 125
LEU A  35
 None
 1.14A 6a7pA-1qcxA:
undetectable		 6a7pA-1qcxA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA502_0
(CANAVALIN)		 1qcx PECTIN LYASE B
(Aspergillus
niger) 		4 / 4 GLY A 119
LYS A 118
GLN A 115
ASN A 139
 None
 1.24A 6cb4A-1qcxA:
0.0		 6cb4A-1qcxA:
21.59