SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qdl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		3 / 3 ASP A  89
ARG A  92
ILE A  97
 None
 0.83A 1a4gB-1qdlA:
undetectable		 1a4gB-1qdlA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 ILE B  31
LEU B  49
VAL B  14
ALA B  18
ILE B  17
 None
 1.01A 1epbB-1qdlB:
undetectable		 1epbB-1qdlB:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 11 ILE B  20
SER B  26
GLY B  25
ASN B 193
GLY B  22
 None
 1.31A 1ho5A-1qdlB:
undetectable		 1ho5A-1qdlB:
18.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		6 / 11 GLU A 225
ILE A 240
GLY A 242
THR A 243
GLU A 269
HIS A 306
 None
 0.99A 1i7qA-1qdlA:
39.9		 1i7qA-1qdlA:
33.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 10 GLU A 225
ILE A 240
GLY A 242
GLU A 269
HIS A 306
 None
 0.98A 1i7qC-1qdlA:
40.0		 1i7qC-1qdlA:
33.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 10 GLU A 225
ILE A 240
GLY A 242
THR A 243
HIS A 306
 None
 0.34A 1i7qC-1qdlA:
40.0		 1i7qC-1qdlA:
33.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		6 / 11 GLY B  95
ALA B  96
ASP B 141
ILE B 159
ILE B  90
ILE B  98
 None
 1.16A 1n49B-1qdlB:
undetectable		 1n49B-1qdlB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		6 / 11 GLY B  95
ALA B  96
ASP B 141
ILE B 159
ILE B  90
ILE B  98
 None
 1.17A 1n49C-1qdlB:
undetectable		 1n49C-1qdlB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 9 TYR B 123
ASP B 150
LEU B 122
VAL B  83
ILE B 159
 None
 1.38A 1q6iA-1qdlB:
undetectable		 1q6iA-1qdlB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 8 LEU A 349
GLU A 350
ILE A 345
TYR A 170
 None
 1.15A 1qvtA-1qdlA:
undetectable		 1qvtA-1qdlA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 7 VAL B 195
GLY B  82
ILE B  51
THR B  78
 None
 0.79A 1t7iB-1qdlB:
undetectable		 1t7iB-1qdlB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 7 VAL B 195
GLY B  82
ILE B  51
THR B  78
 None
 0.81A 1t7jB-1qdlB:
undetectable		 1t7jB-1qdlB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 11 GLN B 173
PHE B 174
HIS B 136
PRO B  58
ILE B  98
 None
 1.35A 2a68M-1qdlB:
0.0		 2a68M-1qdlB:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 10 TYR B  15
ILE B  17
ALA B  18
ILE B  31
ILE B   7
 None
 1.25A 2dm6A-1qdlB:
3.7
2dm6B-1qdlB:
3.7		 2dm6A-1qdlB:
21.79
2dm6B-1qdlB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 9 PHE A 329
GLU A 371
ILE A 374
ALA A 331
VAL A 334
 None
 1.28A 2drdA-1qdlA:
2.5		 2drdA-1qdlA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 SER A 309
TYR A 238
VAL A 311
VAL A 274
HIS A 270
 None
 1.43A 2rguA-1qdlA:
undetectable		 2rguA-1qdlA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 11 SER A 309
TYR A 238
VAL A 311
VAL A 274
HIS A 270
 None
 1.39A 2rguB-1qdlA:
undetectable		 2rguB-1qdlA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 8 MET B 160
ALA B 161
TYR B 123
ILE B 112
 None
 0.87A 2zm9A-1qdlB:
0.0		 2zm9A-1qdlB:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 4 GLU B  35
ARG B  32
ASN B   9
ASP B   8
 None
 1.33A 2zq9A-1qdlB:
undetectable		 2zq9A-1qdlB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 GLY A  84
GLY A 362
ALA A 373
VAL A  25
PHE A 214
 None
 1.01A 2zulA-1qdlA:
undetectable		 2zulA-1qdlA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 6 VAL A  15
LEU A  28
GLU A  30
SER A  11
 None
 1.03A 3b6rB-1qdlA:
undetectable		 3b6rB-1qdlA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 SER A 309
TYR A 238
VAL A 311
VAL A 274
HIS A 270
 None
 1.44A 3bjmA-1qdlA:
undetectable		 3bjmA-1qdlA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 HIS B 175
ILE B 162
GLY B 171
ILE B 169
GLN B  88
 None
 1.06A 3bwcA-1qdlB:
undetectable		 3bwcA-1qdlB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 GLY A  84
GLY A 362
ALA A 373
VAL A  25
PHE A 214
 None
 1.01A 3dmfA-1qdlA:
undetectable		 3dmfA-1qdlA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 GLY A  84
GLY A 362
ALA A 373
VAL A  25
PHE A 214
 None
 1.01A 3dmhA-1qdlA:
undetectable		 3dmhA-1qdlA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 11 LEU A  62
ILE A  86
LEU A 325
PHE A 372
THR A 114
 None
 1.18A 3fl9C-1qdlA:
undetectable		 3fl9C-1qdlA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 9 LEU A  62
ILE A  86
LEU A 325
PHE A 372
THR A 114
 None
 1.17A 3fl9H-1qdlA:
undetectable		 3fl9H-1qdlA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 ILE B 162
GLY B 171
ILE B  50
ALA B 161
VAL B 140
 None
 1.00A 3fpjA-1qdlB:
undetectable		 3fpjA-1qdlB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 SER A 309
TYR A 238
VAL A 311
VAL A 274
HIS A 270
 None
 1.40A 3g0bB-1qdlA:
undetectable		 3g0bB-1qdlA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 4 ILE B  80
ARG B  61
ILE B  51
THR B  78
 None
 1.27A 3ia4C-1qdlB:
0.9		 3ia4C-1qdlB:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 10 ILE B 187
PRO B 176
LYS B 186
GLY B 184
LEU B 122
 None
 1.37A 3ik6B-1qdlB:
0.5
3ik6E-1qdlB:
0.5		 3ik6B-1qdlB:
21.69
3ik6E-1qdlB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 10 LEU B 122
ILE B 187
PRO B 176
LYS B 186
GLY B 184
 None
 1.33A 3ik6B-1qdlB:
undetectable
3ik6E-1qdlB:
undetectable		 3ik6B-1qdlB:
21.69
3ik6E-1qdlB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 11 ILE B 187
PRO B 176
LYS B 186
GLY B 184
LEU B 122
 None
 1.35A 3iluB-1qdlB:
0.5
3iluE-1qdlB:
0.5		 3iluB-1qdlB:
21.69
3iluE-1qdlB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		3 / 3 ARG B 134
GLU A 264
TYR A 396
 None
 0.95A 3k37B-1qdlB:
0.0		 3k37B-1qdlB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 ALA B 161
ILE B  90
ALA B  89
GLU B  59
GLY B  95
 None
 1.03A 3nxuA-1qdlB:
0.0		 3nxuA-1qdlB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 8 ILE B   7
ILE B  31
VAL B  70
ILE B  44
 None
 0.80A 3p4wC-1qdlB:
undetectable		 3p4wC-1qdlB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 11 TYR A  51
LEU A 212
ALA A 110
ILE A  54
THR A 378
 None
 1.13A 3qelA-1qdlA:
undetectable
3qelB-1qdlA:
undetectable		 3qelA-1qdlA:
21.83
3qelB-1qdlA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 5 PHE B  94
ILE B  90
GLY B  75
HIS B 164
 None
 1.22A 3r0lD-1qdlB:
undetectable		 3r0lD-1qdlB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 GLU A 225
ILE A 240
GLY A 242
THR A 243
HIS A 306
 None
 0.38A 3r75A-1qdlA:
41.3		 3r75A-1qdlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 GLU A 225
ILE A 240
GLY A 242
THR A 243
HIS A 306
 None
 0.38A 3r75B-1qdlA:
40.6		 3r75B-1qdlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 11 GLU A 225
ILE A 240
GLY A 242
THR A 243
HIS A 306
 None
 0.39A 3r76A-1qdlA:
41.6		 3r76A-1qdlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 11 GLU A 225
ILE A 240
GLY A 242
THR A 243
HIS A 306
 None
 0.37A 3r76B-1qdlA:
40.7		 3r76B-1qdlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 5 LEU A 281
GLY A 313
PHE A 228
ASN A 233
 None
 1.27A 3uq6B-1qdlA:
undetectable		 3uq6B-1qdlA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 SER A 309
TYR A 238
VAL A 311
VAL A 274
HIS A 270
 None
 1.40A 3w2tA-1qdlA:
undetectable		 3w2tA-1qdlA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 SER A 309
TYR A 238
VAL A 311
VAL A 274
HIS A 270
 None
 1.39A 3w2tB-1qdlA:
undetectable		 3w2tB-1qdlA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 10 ALA A 321
LEU A 325
LEU A  62
ASN A  63
ILE A  86
 None
 1.17A 3wdmD-1qdlA:
undetectable		 3wdmD-1qdlA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 10 GLY B 171
LEU B 188
LEU B 122
ASP B 150
ILE B 187
 None
 1.15A 3wdmD-1qdlB:
2.3		 3wdmD-1qdlB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 8 TYR A  41
VAL A  43
ILE A 118
GLU A 371
 None
 1.07A 4a97C-1qdlA:
undetectable		 4a97C-1qdlA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 8 TYR A  41
VAL A  43
ILE A 118
GLU A 371
 None
 1.00A 4a97G-1qdlA:
0.0		 4a97G-1qdlA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 8 ASP A  73
ILE A  74
VAL A  43
SER A  31
 None
 0.83A 4ac9C-1qdlA:
undetectable		 4ac9C-1qdlA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 8 ASP A  73
ILE A  74
VAL A  43
SER A  31
 None
 0.88A 4acbB-1qdlA:
undetectable
4acbC-1qdlA:
undetectable		 4acbB-1qdlA:
22.64
4acbC-1qdlA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 7 SER A 159
ARG A 162
ILE A 163
ASN A 156
 None
 1.12A 4d39B-1qdlA:
0.0		 4d39B-1qdlA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		3 / 3 TYR A 357
HIS A 389
ARG A 354
 None
 1.21A 4e7bC-1qdlA:
0.0		 4e7bC-1qdlA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 6 PRO B 176
ILE B 112
TYR B 123
PHE B 130
 None
 1.03A 4g10A-1qdlB:
undetectable		 4g10A-1qdlB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 GLY B  54
PRO B  55
ILE B  64
ASN B  33
VAL B  30
 None
 0.77A 4gc9A-1qdlB:
undetectable		 4gc9A-1qdlB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 HIS B 175
VAL B 172
LEU B 122
LEU B  81
VAL B  83
 None
 0.98A 4k13A-1qdlB:
undetectable		 4k13A-1qdlB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 11 GLY B  95
ASP B 141
ILE B  90
THR B  57
ILE B  98
 None
 1.02A 4njvB-1qdlB:
undetectable		 4njvB-1qdlB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 7 LEU A  77
ILE A 118
ILE A 120
VAL A  43
 None
 0.87A 4ojbA-1qdlA:
0.0		 4ojbA-1qdlA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 6 LEU A  62
ASN A  63
LEU A 325
VAL A 284
 None
 1.10A 4okbA-1qdlA:
0.0		 4okbA-1qdlA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		3 / 3 GLU A 125
LYS A 127
ASN A 124
 None
 1.06A 4y1dA-1qdlA:
0.0
4y1dD-1qdlA:
undetectable		 4y1dA-1qdlA:
17.19
4y1dD-1qdlA:
1.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 4 THR A 333
GLU A 225
THR A 243
HIS A 306
 None
 1.42A 4ydqA-1qdlA:
undetectable		 4ydqA-1qdlA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 TYR A  51
LEU A 212
ALA A 110
ILE A  54
THR A 378
 None
 1.15A 5ewjC-1qdlA:
undetectable
5ewjD-1qdlA:
undetectable		 5ewjC-1qdlA:
22.56
5ewjD-1qdlA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_1
(AMINOACYL-TRNA
SYNTHETASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 4 THR A 333
GLU A 225
THR A 243
HIS A 306
 None
 1.39A 5f9zA-1qdlA:
undetectable		 5f9zA-1qdlA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_1
(AMINOACYL-TRNA
SYNTHETASE)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 4 THR A 333
GLU A 225
THR A 243
HIS A 306
 None
 1.39A 5f9zB-1qdlA:
undetectable		 5f9zB-1qdlA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 ILE B  17
ALA B  18
GLY B  54
GLY B  82
VAL B  83
 None
 1.18A 5i71A-1qdlB:
undetectable		 5i71A-1qdlB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 ILE B  17
ALA B  18
GLY B  54
GLY B  82
VAL B  83
 None
 1.17A 5i75A-1qdlB:
undetectable		 5i75A-1qdlB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 10 TYR B  27
PRO B  28
ILE B   6
ILE B  44
ILE B  41
 None
 0.99A 5murE-1qdlB:
undetectable		 5murE-1qdlB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 GLY A 242
ASP A 266
LYS A 265
GLU A 259
THR A 243
 None
 1.24A 5x6yC-1qdlA:
undetectable		 5x6yC-1qdlA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		5 / 12 SER A 309
TYR A 238
VAL A 311
VAL A 274
HIS A 270
 None
 1.42A 6b1eB-1qdlA:
undetectable		 6b1eB-1qdlA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
(Sulfolobus
solfataricus) 		4 / 6 SER A 335
TYR A  88
GLN A 178
GLU A 350
 None
 1.45A 6djzA-1qdlA:
undetectable		 6djzA-1qdlA:
19.81