SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qdu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1qdu CASPASE-8
ALPHA-CHAIN
(Homo
sapiens) 		5 / 10 ASN A 169
PHE A 173
ARG A 175
ALA A 174
ILE A 243
 None
 1.07A 2aclC-1qduA:
undetectable		 2aclC-1qduA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 1qdu CASPASE-8
ALPHA-CHAIN
(Homo
sapiens) 		4 / 5 ASN A 180
ARG A 179
ASN A 169
HIS A 204
 None
 1.22A 3frqA-1qduA:
undetectable		 3frqA-1qduA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1qdu CASPASE-8
ALPHA-CHAIN
(Homo
sapiens) 		4 / 7 ASN A 180
ARG A 179
ASN A 169
HIS A 204
 None
 1.22A 3frqB-1qduA:
undetectable		 3frqB-1qduA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1qdu CASPASE-8
ALPHA-CHAIN
(Homo
sapiens) 		4 / 5 GLN A 264
ILE A 243
LEU A 261
PHE A 265
 None
 1.19A 3ls4L-1qduA:
undetectable		 3ls4L-1qduA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1qdu CASPASE-8
ALPHA-CHAIN
(Homo
sapiens) 		4 / 5 GLN A 264
ILE A 258
LEU A 261
PHE A 265
 None
 0.97A 3ls4L-1qduA:
undetectable		 3ls4L-1qduA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1qdu CASPASE-8
ALPHA-CHAIN
(Homo
sapiens) 		5 / 12 ILE A 176
GLY A 245
GLY A 248
ILE A 242
SER A 236
 None
 1.14A 4iv0B-1qduA:
2.0		 4iv0B-1qduA:
20.35