SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1qez PROTEIN (INORGANIC
PYROPHOSPHATASE)
(Sulfolobus
acidocaldarius) 		5 / 7 PRO A1086
GLY A1088
ALA A1158
ALA A1100
ARG A1161
 None
 1.45A 3ur0B-1qezA:
undetectable		 3ur0B-1qezA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1qez PROTEIN (INORGANIC
PYROPHOSPHATASE)
(Sulfolobus
acidocaldarius) 		5 / 9 PRO A1086
GLY A1088
ALA A1158
ALA A1100
ARG A1161
 None
 1.49A 3ur0C-1qezA:
undetectable		 3ur0C-1qezA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1qez PROTEIN (INORGANIC
PYROPHOSPHATASE)
(Sulfolobus
acidocaldarius) 		4 / 4 ILE A1102
ILE A1089
ARG A1161
LEU A1069
 None
 1.27A 5dzkh-1qezA:
undetectable
5dzkn-1qezA:
undetectable
5dzkv-1qezA:
undetectable		 5dzkh-1qezA:
24.06
5dzkn-1qezA:
24.06
5dzkv-1qezA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1qez PROTEIN (INORGANIC
PYROPHOSPHATASE)
(Sulfolobus
acidocaldarius) 		5 / 12 ASP A1030
PRO A1065
GLY A1053
GLU A1018
GLU A1028
 None
 1.15A 5hfjD-1qezA:
undetectable		 5hfjD-1qezA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1qez PROTEIN (INORGANIC
PYROPHOSPHATASE)
(Sulfolobus
acidocaldarius) 		5 / 12 ASP A1030
PRO A1065
GLY A1053
GLU A1018
TYR A1052
 None
 1.07A 5hfjD-1qezA:
undetectable		 5hfjD-1qezA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 1qez PROTEIN (INORGANIC
PYROPHOSPHATASE)
(Sulfolobus
acidocaldarius) 		4 / 5 TYR A1048
LYS A1026
GLU A1018
GLY A1053
 None
 1.13A 5jhdJ-1qezA:
0.0		 5jhdJ-1qezA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1qez PROTEIN (INORGANIC
PYROPHOSPHATASE)
(Sulfolobus
acidocaldarius) 		5 / 12 ILE A1102
SER A1150
GLU A1157
GLY A1153
GLY A1088
 None
 1.09A 5l6eA-1qezA:
undetectable		 5l6eA-1qezA:
23.91