SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qfc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		3 / 3 ALA A 241
VAL A  12
TRP A  15
 None
 0.86A 1av2A-1qfcA:
undetectable
1av2B-1qfcA:
undetectable		 1av2A-1qfcA:
5.00
1av2B-1qfcA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		3 / 3 TRP A  15
ALA A 241
VAL A  12
 None
 0.91A 1av2C-1qfcA:
undetectable
1av2D-1qfcA:
undetectable		 1av2C-1qfcA:
5.00
1av2D-1qfcA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		3 / 3 ALA A 241
VAL A  12
TRP A  15
 None
 0.93A 1c4dC-1qfcA:
undetectable
1c4dD-1qfcA:
undetectable		 1c4dC-1qfcA:
5.00
1c4dD-1qfcA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		3 / 3 TRP A  15
ALA A 241
VAL A  12
 None
 0.87A 1c4dC-1qfcA:
undetectable
1c4dD-1qfcA:
undetectable		 1c4dC-1qfcA:
5.00
1c4dD-1qfcA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		4 / 8 ALA A 100
ILE A 107
PHE A  67
VAL A  59
 NAG  A 400 ( 4.0A)
None
None
None
 0.75A 1d4sB-1qfcA:
undetectable		 1d4sB-1qfcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		5 / 8 ALA A  11
LEU A  88
LEU A  50
LEU A 218
ALA A 184
 None
 1.18A 1e7cA-1qfcA:
undetectable		 1e7cA-1qfcA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		3 / 3 ALA A 241
VAL A  12
TRP A  15
 None
 0.84A 1w5uA-1qfcA:
undetectable
1w5uB-1qfcA:
undetectable		 1w5uA-1qfcA:
5.00
1w5uB-1qfcA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		3 / 3 TRP A  15
ALA A 241
VAL A  12
 None
 0.90A 1w5uA-1qfcA:
undetectable
1w5uB-1qfcA:
undetectable		 1w5uA-1qfcA:
5.00
1w5uB-1qfcA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		3 / 3 TRP A  15
ALA A 241
VAL A  12
 None
 0.87A 2izqC-1qfcA:
undetectable
2izqD-1qfcA:
undetectable		 2izqC-1qfcA:
5.00
2izqD-1qfcA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		5 / 8 LEU A 141
MET A 135
GLY A 185
LEU A  88
ASP A  93
 None
 1.49A 2yfxA-1qfcA:
undetectable		 2yfxA-1qfcA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		3 / 3 ASN A  53
MET A  29
PHE A  23
 None
 1.12A 3g4lD-1qfcA:
0.6		 3g4lD-1qfcA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		3 / 3 TRP A  15
ALA A 241
VAL A  12
 None
 0.88A 3l8lC-1qfcA:
undetectable
3l8lD-1qfcA:
undetectable		 3l8lC-1qfcA:
5.00
3l8lD-1qfcA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		5 / 12 LEU A 225
TYR A 287
ILE A 285
ILE A  35
ALA A  11
 None
 1.35A 3uj7A-1qfcA:
0.4		 3uj7A-1qfcA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		4 / 7 GLU A  69
PHE A  23
TYR A 104
VAL A  98
 None
 0.95A 4a97D-1qfcA:
undetectable		 4a97D-1qfcA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		4 / 6 GLU A  69
PHE A  23
TYR A 104
VAL A  98
 None
 0.96A 4a97E-1qfcA:
0.0		 4a97E-1qfcA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		4 / 8 ARG A  37
GLY A  43
ALA A  44
ASP A  45
 None
 0.83A 4eyrB-1qfcA:
undetectable		 4eyrB-1qfcA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		3 / 3 LEU A 300
PRO A 301
ARG A 206
 None
 0.68A 4klrB-1qfcA:
undetectable		 4klrB-1qfcA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		5 / 12 TYR A 236
GLY A 235
LEU A 136
LEU A 208
THR A 215
 None
 1.08A 4ze1A-1qfcA:
undetectable		 4ze1A-1qfcA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EU8_B_010B6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		4 / 5 LEU A 238
HIS A 221
THR A 198
CYH A 219
 None
FE  A 401 (-3.2A)
None
None
 1.32A 5eu8A-1qfcA:
0.0		 5eu8A-1qfcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)
(Rattus
norvegicus) 		5 / 12 GLY A 242
GLY A 272
SER A 239
PHE A 244
TYR A  55
 None
None
None
None
FE  A 402 ( 4.1A)
 1.33A 5yf0A-1qfcA:
undetectable		 5yf0A-1qfcA:
20.80