SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qfh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 1qfh PROTEIN (GELATION
FACTOR)
(Dictyostelium
discoideum) 		4 / 6 LEU A 701
GLU A 724
ASP A 666
PRO A 722
 None
 1.03A 1ditH-1qfhA:
0.0
1ditP-1qfhA:
undetectable		 1ditH-1qfhA:
20.60
1ditP-1qfhA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 1qfh PROTEIN (GELATION
FACTOR)
(Dictyostelium
discoideum) 		4 / 6 ASP A 666
VAL A 664
GLY A 725
TYR A 727
 None
 1.27A 1ekjC-1qfhA:
undetectable
1ekjD-1qfhA:
undetectable		 1ekjC-1qfhA:
23.27
1ekjD-1qfhA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1qfh PROTEIN (GELATION
FACTOR)
(Dictyostelium
discoideum) 		5 / 12 ALA A 767
VAL A 765
THR A 855
PHE A 782
LYS A 781
 None
 1.08A 2v95A-1qfhA:
undetectable		 2v95A-1qfhA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 1qfh PROTEIN (GELATION
FACTOR)
(Dictyostelium
discoideum) 		4 / 5 PHE A 850
LEU A 811
GLY A 813
VAL A 847
 None
 0.93A 3wrkD-1qfhA:
undetectable		 3wrkD-1qfhA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1qfh PROTEIN (GELATION
FACTOR)
(Dictyostelium
discoideum) 		4 / 8 TYR A 727
VAL A 745
MET A 741
ILE A 743
 None
 1.09A 4a97I-1qfhA:
2.2		 4a97I-1qfhA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1qfh PROTEIN (GELATION
FACTOR)
(Dictyostelium
discoideum) 		5 / 7 VAL A 717
ILE A 674
PHE A 691
VAL A 693
ILE A 695
 None
 1.37A 5bmvC-1qfhA:
undetectable		 5bmvC-1qfhA:
19.70