SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qfj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 1qfj PROTEIN (FLAVIN
REDUCTASE)
(Escherichia
coli) 		4 / 8 GLY A 138
TRP A 137
GLY A 139
VAL A  17
 None
 0.92A 1dbbH-1qfjA:
undetectable
1dbbL-1qfjA:
undetectable		 1dbbH-1qfjA:
20.31
1dbbL-1qfjA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1qfj PROTEIN (FLAVIN
REDUCTASE)
(Escherichia
coli) 		4 / 7 LEU A 192
ALA A 219
PHE A 213
TYR A 198
 None
 0.86A 1epbA-1qfjA:
undetectable		 1epbA-1qfjA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1qfj PROTEIN (FLAVIN
REDUCTASE)
(Escherichia
coli) 		4 / 8 LEU A 192
ALA A 219
PHE A 213
TYR A 198
 None
 0.81A 1epbB-1qfjA:
undetectable		 1epbB-1qfjA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1qfj PROTEIN (FLAVIN
REDUCTASE)
(Escherichia
coli) 		4 / 7 LEU A 182
VAL A 166
TYR A 136
GLY A 138
 None
 1.00A 1lweA-1qfjA:
undetectable		 1lweA-1qfjA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1qfj PROTEIN (FLAVIN
REDUCTASE)
(Escherichia
coli) 		4 / 8 ASP A 227
GLY A 226
PHE A 225
TYR A  35
 GOL  A 601 (-4.2A)
None
None
GOL  A 601 (-3.4A)
 0.95A 2tsrB-1qfjA:
undetectable		 2tsrB-1qfjA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 1qfj PROTEIN (FLAVIN
REDUCTASE)
(Escherichia
coli) 		4 / 7 PRO A  54
LEU A 107
ALA A  32
PHE A  30
 None
 1.01A 3tehB-1qfjA:
2.4		 3tehB-1qfjA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1qfj PROTEIN (FLAVIN
REDUCTASE)
(Escherichia
coli) 		3 / 3 ARG A 223
ARG A 131
ASP A  99
 None
 0.98A 3wipG-1qfjA:
1.1
3wipH-1qfjA:
1.1		 3wipG-1qfjA:
22.93
3wipH-1qfjA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1qfj PROTEIN (FLAVIN
REDUCTASE)
(Escherichia
coli) 		4 / 8 LEU A 122
ARG A  19
HIS A 158
LEU A 161
 None
 1.12A 5dxeA-1qfjA:
undetectable		 5dxeA-1qfjA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1qfj PROTEIN (FLAVIN
REDUCTASE)
(Escherichia
coli) 		3 / 3 THR A 134
MET A 105
HIS A 195
 None
 0.72A 5uunA-1qfjA:
undetectable		 5uunA-1qfjA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1qfj PROTEIN (FLAVIN
REDUCTASE)
(Escherichia
coli) 		4 / 8 LEU A 122
ARG A  19
HIS A 158
LEU A 161
 None
 1.11A 6cbzA-1qfjA:
undetectable		 6cbzA-1qfjA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1qfj PROTEIN (FLAVIN
REDUCTASE)
(Escherichia
coli) 		5 / 9 LEU A  62
PRO A  24
PHE A  28
VAL A  88
ILE A  22
 None
 1.03A 6ef6A-1qfjA:
undetectable		 6ef6A-1qfjA:
19.89