SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qfw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI ALPHA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus) 		8 / 12 TYR L  40
GLN L  93
TYR L 100
PHE L 104
TRP H  33
VAL H  37
ALA H  97
TRP H 107
 None
 0.88A 1h8sA-1qfwL:
17.8		 1h8sA-1qfwL:
54.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI ALPHA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus) 		4 / 7 GLN L  38
ARG H  98
LEU L  50
ASP H 105
 None
 0.87A 2qqcB-1qfwL:
undetectable
2qqcC-1qfwL:
undetectable		 2qqcB-1qfwL:
20.93
2qqcC-1qfwL:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI ALPHA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus) 		4 / 7 LEU L  50
ASP H 105
GLN L  38
ARG H  98
 None
 0.84A 2qqcA-1qfwL:
undetectable
2qqcF-1qfwL:
undetectable		 2qqcA-1qfwL:
13.16
2qqcF-1qfwL:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI ALPHA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus) 		4 / 7 GLN L  38
ARG H  98
LEU L  50
ASP H 105
 None
 0.82A 2qqcD-1qfwL:
undetectable
2qqcE-1qfwL:
undetectable		 2qqcD-1qfwL:
20.93
2qqcE-1qfwL:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI ALPHA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus) 		4 / 7 LEU L  50
ASP H 105
GLN L  38
ARG H  98
 None
 0.83A 2qqcG-1qfwL:
undetectable
2qqcJ-1qfwL:
undetectable		 2qqcG-1qfwL:
13.16
2qqcJ-1qfwL:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI ALPHA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus) 		4 / 7 LEU L  50
ASP H 105
GLN L  38
ARG H  98
 None
 0.87A 2qqcI-1qfwL:
undetectable
2qqcL-1qfwL:
undetectable		 2qqcI-1qfwL:
13.16
2qqcL-1qfwL:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI ALPHA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus) 		4 / 8 GLN L  38
ARG H  98
LEU L  50
ASP H 105
 None
 0.86A 2qqcH-1qfwL:
undetectable
2qqcK-1qfwL:
undetectable		 2qqcH-1qfwL:
20.93
2qqcK-1qfwL:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1qfw ANTIBODY (ANTI BETA
SUBUNIT) (HEAVY
CHAIN)
(Mus
musculus) 		5 / 12 GLN I 299
PHE I 309
ARG I 238
ILE I 237
SER I 235
 None
 1.26A 2vdyB-1qfwI:
undetectable		 2vdyB-1qfwI:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1qfw ANTIBODY (ANTI BETA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI BETA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus) 		5 / 12 PHE I 309
ARG I 238
ILE I 237
SER I 235
HIS M 294
 None
 1.18A 2vdyB-1qfwI:
undetectable		 2vdyB-1qfwI:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1qfw ANTIBODY (ANTI BETA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI BETA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus) 		5 / 12 PHE I 309
ARG I 238
ILE I 237
SER I 235
PHE M 298
 None
 1.33A 2vdyB-1qfwI:
undetectable		 2vdyB-1qfwI:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1qfw ANTIBODY (ANTI BETA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI BETA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus) 		5 / 12 THR M 291
PHE I 309
ARG I 238
ILE I 237
SER I 235
 None
 1.20A 2vdyB-1qfwM:
0.0		 2vdyB-1qfwM:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI ALPHA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus) 		5 / 9 ASP L   9
THR L  89
TYR L  91
GLY L 107
LEU H  45
 None
 1.40A 3sfuB-1qfwL:
undetectable		 3sfuB-1qfwL:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1qfw ANTIBODY (ANTI BETA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI BETA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus) 		5 / 12 ARG I 238
ARG I 287
SER I 263
GLU I 289
ASP M 201
 None
 1.17A 3u40B-1qfwI:
undetectable
3u40C-1qfwI:
undetectable		 3u40B-1qfwI:
19.17
3u40C-1qfwI:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1qfw ANTIBODY (ANTI BETA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI BETA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus) 		5 / 11 GLN I 299
PHE I 309
ILE I 237
SER I 235
HIS M 294
 None
 1.18A 4bb2A-1qfwI:
undetectable
4bb2B-1qfwI:
0.0		 4bb2A-1qfwI:
16.42
4bb2B-1qfwI:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI ALPHA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus;
Mus
musculus) 		3 / 3 ASP H 105
LEU L  50
PHE H 104
 None
 0.71A 4pthA-1qfwH:
undetectable		 4pthA-1qfwH:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 1qfw ANTIBODY (ANTI BETA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus) 		4 / 8 SER M 234
TYR M 236
GLY M 289
PHE M 298
 None
 0.47A 5albL-1qfwM:
17.6		 5albL-1qfwM:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 1qfw ANTIBODY (ANTI BETA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus) 		4 / 8 SER M 234
TYR M 236
GLY M 289
PHE M 298
 None
 0.49A 5alcL-1qfwM:
17.7		 5alcL-1qfwM:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
(Mus
musculus) 		3 / 3 THR H  28
SER H  31
TYR H  32
 None
 0.78A 5jsdA-1qfwH:
undetectable		 5jsdA-1qfwH:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
(Mus
musculus) 		3 / 3 THR H  28
SER H  31
TYR H  32
 None
 0.78A 5jsdB-1qfwH:
1.1		 5jsdB-1qfwH:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
(Mus
musculus) 		3 / 3 THR H  28
SER H  31
TYR H  32
 None
 0.77A 5jsdC-1qfwH:
undetectable		 5jsdC-1qfwH:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
(Mus
musculus) 		3 / 3 THR H  28
SER H  31
TYR H  32
 None
 0.77A 5jseA-1qfwH:
undetectable		 5jseA-1qfwH:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
(Mus
musculus) 		3 / 3 THR H  28
SER H  31
TYR H  32
 None
 0.77A 5jseB-1qfwH:
undetectable		 5jseB-1qfwH:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
(Mus
musculus) 		3 / 3 THR H  28
SER H  31
TYR H  32
 None
 0.77A 5jseC-1qfwH:
undetectable		 5jseC-1qfwH:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1qfw ANTIBODY (ANTI BETA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI BETA
SUBUNIT) (LIGHT
CHAIN)
(Mus
musculus;
Mus
musculus) 		5 / 8 GLY I 300
PHE I 309
VAL I 311
GLY M 250
SER M 234
 None
 1.20A 6hu9H-1qfwI:
undetectable
6hu9e-1qfwI:
undetectable		 6hu9H-1qfwI:
20.57
6hu9e-1qfwI:
21.33