SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qge'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		4 / 8 SER D 117
PHE D 119
LEU D 161
LEU D 127
 None
 0.91A 2bfpC-1qgeD:
2.3		 2bfpC-1qgeD:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		3 / 3 ALA E 226
GLY E 264
SER E 259
 None
 0.57A 2ivuA-1qgeE:
undetectable		 2ivuA-1qgeE:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		5 / 12 THR D 112
VAL D  14
ALA D  47
VAL D  72
VAL D  44
 None
 1.26A 2nniA-1qgeD:
0.0		 2nniA-1qgeD:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		3 / 3 ARG D  94
VAL E 276
THR D 192
 None
 0.86A 2nnkA-1qgeD:
undetectable		 2nnkA-1qgeD:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		3 / 3 THR D  20
ASP D  55
SER D  93
 None
 0.83A 2nxeA-1qgeD:
2.2		 2nxeA-1qgeD:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		5 / 12 VAL D  14
LEU D 167
ASP D  55
LEU D  91
TYR D  29
 None
 1.14A 2oipC-1qgeD:
undetectable		 2oipC-1qgeD:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		4 / 6 LEU D  65
VAL D  69
LYS D  70
ILE D  12
 None
 0.63A 2piwA-1qgeD:
undetectable		 2piwA-1qgeD:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		5 / 11 LEU D 149
VAL D 145
ILE E 289
ASP E 263
ASP E 287
 None
None
None
None
CA  E 320 (-3.4A)
 1.27A 2q6hA-1qgeD:
0.0		 2q6hA-1qgeD:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		5 / 12 VAL D 138
ALA E 246
LEU E 265
PHE D 119
ILE D 139
 None
 1.09A 2w3vA-1qgeD:
2.7		 2w3vA-1qgeD:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		4 / 8 THR D 108
TYR D 207
ILE E 277
SER D 106
 None
 1.10A 2xytH-1qgeD:
undetectable		 2xytH-1qgeD:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		4 / 7 THR D 108
TYR D 207
ILE E 277
SER D 106
 None
 1.12A 2xytI-1qgeD:
undetectable		 2xytI-1qgeD:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae;
Burkholderia
glumae) 		5 / 12 SER E 270
SER D  54
LEU D 164
ASP D 121
GLU D 118
 None
 1.43A 3aocC-1qgeE:
undetectable		 3aocC-1qgeE:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		5 / 12 GLY D  62
GLY D  60
GLN D  88
ALA D  67
LEU D  83
 None
 1.08A 3dh0B-1qgeD:
undetectable		 3dh0B-1qgeD:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		4 / 7 LEU E 292
LEU D 164
LEU E 247
LEU D 134
 None
 0.94A 3g8iA-1qgeE:
undetectable		 3g8iA-1qgeE:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		3 / 3 SER D 153
ASP D  21
ASP D 157
 None
 0.88A 3iv6C-1qgeD:
undetectable		 3iv6C-1qgeD:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae;
Burkholderia
glumae) 		3 / 3 GLY D 210
ILE E 307
VAL E 306
 None
 0.51A 3nv6A-1qgeD:
undetectable		 3nv6A-1qgeD:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		4 / 6 THR D 108
TYR D 207
ILE E 277
SER D 106
 None
 1.30A 3peoG-1qgeD:
undetectable		 3peoG-1qgeD:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		3 / 3 ARG D  94
VAL E 276
THR D 192
 None
 0.77A 3pwrA-1qgeD:
undetectable		 3pwrA-1qgeD:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae;
Burkholderia
glumae) 		4 / 5 HIS E 285
ILE E 289
HIS D  86
LEU D  17
 None
 1.22A 3qpkA-1qgeE:
undetectable		 3qpkA-1qgeE:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		3 / 3 ARG D  94
VAL E 276
THR D 192
 None
 0.88A 3tl9A-1qgeD:
undetectable		 3tl9A-1qgeD:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae;
Burkholderia
glumae) 		5 / 8 GLY D  16
GLY D  89
SER D  87
GLY D 111
VAL E 266
 None
 1.42A 3v1nA-1qgeD:
8.7		 3v1nA-1qgeD:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		4 / 6 ASP E 287
GLY E 264
PRO D 113
THR D 112
 CA  E 320 (-3.4A)
None
None
None
 1.10A 4l1aB-1qgeE:
undetectable		 4l1aB-1qgeE:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		5 / 12 VAL D  14
LEU D 167
ASP D  55
LEU D  91
TYR D  29
 None
 1.12A 4q0dA-1qgeD:
undetectable		 4q0dA-1qgeD:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		5 / 12 VAL D  14
LEU D 167
ASP D  55
LEU D  91
TYR D  29
 None
 1.12A 4q0dB-1qgeD:
2.3		 4q0dB-1qgeD:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		5 / 12 VAL D  14
LEU D 167
ASP D  55
LEU D  91
TYR D  29
 None
 1.12A 4q0dE-1qgeD:
undetectable		 4q0dE-1qgeD:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		4 / 7 PRO D 216
SER E 267
GLU D 118
THR D 172
 None
 1.11A 4uacA-1qgeD:
undetectable		 4uacA-1qgeD:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		5 / 10 GLY E 232
ALA E 300
ASP E 287
SER E 230
ALA D 213
 None
None
CA  E 320 (-3.4A)
None
None
 1.26A 4wnuD-1qgeE:
undetectable		 4wnuD-1qgeE:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae;
Burkholderia
glumae) 		4 / 6 HIS E 285
MET E 254
LEU D 167
LEU D 164
 None
 1.25A 5dzke-1qgeE:
undetectable
5dzks-1qgeE:
undetectable		 5dzke-1qgeE:
19.05
5dzks-1qgeE:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		5 / 12 ILE D 214
ALA D 141
VAL D 138
GLY D 147
THR D 148
 None
 1.11A 5igiA-1qgeD:
undetectable		 5igiA-1qgeD:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		5 / 9 THR E 250
GLY E 251
ALA E 252
GLY E 264
LEU E 265
 None
 1.30A 5vw4A-1qgeE:
undetectable		 5vw4A-1qgeE:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae;
Burkholderia
glumae) 		5 / 9 THR D 212
GLY D 211
ALA D 213
GLY D 210
SER E 278
 None
 1.30A 5vw4A-1qgeD:
2.4		 5vw4A-1qgeD:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae;
Burkholderia
glumae) 		5 / 9 THR E 250
GLY E 251
ALA E 252
LEU E 265
SER D 117
 None
 1.16A 5vw4A-1qgeE:
undetectable		 5vw4A-1qgeE:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		5 / 12 LEU D  65
GLY D  62
ALA D  47
GLY D  89
ALA D  18
 None
 0.94A 5xv7A-1qgeD:
undetectable		 5xv7A-1qgeD:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
(Burkholderia
glumae) 		5 / 7 GLY D  51
LYS D  22
ASN D  59
GLU D  63
GLY D  62
 None
 1.46A 6n7fA-1qgeD:
0.2		 6n7fA-1qgeD:
17.59