SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		4 / 8 LEU A 189
SER A 187
PHE A 186
GLY A 185
 None
 1.01A 1fapB-1qgzA:
0.0		 1fapB-1qgzA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		4 / 6 ALA A 273
SER A 223
TRP A 188
LEU A 274
 None
SO4  A 307 (-2.6A)
None
None
 1.02A 1gahA-1qgzA:
undetectable		 1gahA-1qgzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		4 / 5 LEU A 247
ALA A 241
LEU A 274
SER A 275
 None
 1.12A 1tt6B-1qgzA:
undetectable		 1tt6B-1qgzA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		5 / 12 LEU A 189
GLY A 158
CYH A  98
ALA A 160
ALA A  82
 None
None
None
FAD  A 304 ( 4.0A)
None
 1.19A 2bm9D-1qgzA:
3.2		 2bm9D-1qgzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		5 / 12 LEU A 189
GLY A 158
CYH A  98
ALA A 160
ALA A  82
 None
None
None
FAD  A 304 ( 4.0A)
None
 1.06A 2br4A-1qgzA:
3.5		 2br4A-1qgzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		5 / 12 LEU A 189
GLY A 158
CYH A  98
ALA A 160
ALA A  82
 None
None
None
FAD  A 304 ( 4.0A)
None
 1.14A 2br4C-1qgzA:
3.7		 2br4C-1qgzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		5 / 12 LEU A 189
GLY A 158
CYH A  98
ALA A 160
ALA A  82
 None
None
None
FAD  A 304 ( 4.0A)
None
 1.15A 2br4D-1qgzA:
2.9		 2br4D-1qgzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		5 / 11 ARG A  77
LEU A  76
LEU A  52
PHE A  21
GLY A  23
 FAD  A 304 (-4.2A)
None
None
None
None
 1.29A 2bxmA-1qgzA:
undetectable		 2bxmA-1qgzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		5 / 12 ILE A 159
LEU A 189
GLY A 192
SER A 223
GLN A 226
 None
None
None
SO4  A 307 (-2.6A)
None
 1.18A 2e7fB-1qgzA:
undetectable		 2e7fB-1qgzA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		5 / 12 GLY A 262
GLY A 156
ILE A 199
LEU A 189
LEU A 218
 None
 0.98A 2nxeB-1qgzA:
2.1		 2nxeB-1qgzA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		5 / 12 ILE A 159
LEU A 189
GLY A 192
SER A 223
GLN A 226
 None
None
None
SO4  A 307 (-2.6A)
None
 1.14A 2ogyB-1qgzA:
undetectable		 2ogyB-1qgzA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1162_1
(ALLERGEN ARG R 1)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		4 / 4 GLU A  56
ASP A  92
HIS A  86
GLU A 174
 None
 1.27A 2x45A-1qgzA:
0.0		 2x45A-1qgzA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		5 / 12 ILE A 159
LEU A 189
GLY A 192
SER A 223
GLN A 226
 None
None
None
SO4  A 307 (-2.6A)
None
 1.19A 2ycjA-1qgzA:
undetectable		 2ycjA-1qgzA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		5 / 12 GLY A  23
ILE A 132
TYR A  54
ALA A  82
SER A  96
 None
 1.02A 3hs6B-1qgzA:
undetectable		 3hs6B-1qgzA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		5 / 12 LEU A  31
LEU A 205
THR A 157
ILE A 159
ALA A 160
 None
None
FAD  A 304 (-3.6A)
None
FAD  A 304 ( 4.0A)
 0.65A 3mdvB-1qgzA:
undetectable		 3mdvB-1qgzA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		5 / 12 LEU A  31
THR A 157
ILE A 159
ALA A 160
THR A 164
 None
FAD  A 304 (-3.6A)
None
FAD  A 304 ( 4.0A)
None
 0.89A 3mdvB-1qgzA:
undetectable		 3mdvB-1qgzA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		5 / 12 ILE A 222
ALA A 221
THR A 219
LEU A 166
LEU A 205
 None
 1.28A 3s79A-1qgzA:
undetectable		 3s79A-1qgzA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		4 / 5 ILE A  39
THR A 122
THR A 119
SER A 118
 None
None
None
FAD  A 304 (-2.5A)
 0.99A 3snfA-1qgzA:
undetectable		 3snfA-1qgzA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		4 / 5 VAL A 240
LEU A 247
LEU A 274
ILE A 260
 None
 0.93A 4a9jB-1qgzA:
undetectable		 4a9jB-1qgzA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		4 / 5 VAL A 240
LEU A 247
LEU A 274
ILE A 260
 None
 0.91A 4a9jC-1qgzA:
undetectable		 4a9jC-1qgzA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		5 / 8 ASN A 149
ALA A 148
PRO A 146
LEU A 142
TYR A 259
 None
 1.32A 4jjkA-1qgzA:
undetectable		 4jjkA-1qgzA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		4 / 7 GLU A 204
TYR A 201
GLU A  29
ARG A 163
 None
 1.06A 4mi4B-1qgzA:
undetectable
4mi4C-1qgzA:
undetectable		 4mi4B-1qgzA:
21.69
4mi4C-1qgzA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		4 / 8 GLU A 204
TYR A 201
GLU A  29
ARG A 163
 None
 1.07A 4mj8B-1qgzA:
0.0
4mj8C-1qgzA:
undetectable		 4mj8B-1qgzA:
20.00
4mj8C-1qgzA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		7 / 9 SER A  80
THR A 157
GLY A 158
ALA A 160
CYH A 261
GLY A 262
LEU A 263
 FAD  A 304 (-3.4A)
FAD  A 304 (-3.6A)
None
FAD  A 304 ( 4.0A)
None
None
None
 0.34A 5vw4A-1qgzA:
38.9		 5vw4A-1qgzA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		6 / 8 SER A  80
THR A 157
GLY A 158
CYH A 261
GLY A 262
LEU A 263
 FAD  A 304 (-3.4A)
FAD  A 304 (-3.6A)
None
None
None
None
 0.26A 5vw5A-1qgzA:
38.9		 5vw5A-1qgzA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		6 / 8 SER A  80
THR A 157
GLY A 158
ALA A 160
CYH A 261
GLY A 262
 FAD  A 304 (-3.4A)
FAD  A 304 (-3.6A)
None
FAD  A 304 ( 4.0A)
None
None
 0.29A 5vw9A-1qgzA:
40.0		 5vw9A-1qgzA:
44.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		5 / 12 VAL A 130
PHE A  21
ILE A 132
SER A  27
ILE A  95
 None
 1.39A 6gsdA-1qgzA:
4.2		 6gsdA-1qgzA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		4 / 6 LEU A  14
TYR A  15
VAL A  99
GLY A  50
 None
None
FAD  A 304 (-3.8A)
None
 0.97A 6hd4B-1qgzA:
undetectable		 6hd4B-1qgzA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)
(Nostoc
sp.
PCC
7119) 		4 / 5 LEU A 263
TYR A 303
ILE A 124
GLY A 158
 None
FAD  A 304 (-3.5A)
None
None
 1.05A 6hd6A-1qgzA:
undetectable		 6hd6A-1qgzA:
17.96