SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qhg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 1.03A 1cqeA-1qhgA:
undetectable		 1cqeA-1qhgA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 1.03A 1cqeB-1qhgA:
undetectable		 1cqeB-1qhgA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 468
ILE A 414
ASP A 407
PRO A 405
 None
 1.08A 1ditH-1qhgA:
undetectable
1ditP-1qhgA:
undetectable		 1ditH-1qhgA:
16.83
1ditP-1qhgA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 395
PHE A 386
LEU A 516
VAL A 484
 None
 0.82A 1fslA-1qhgA:
2.1		 1fslA-1qhgA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 638
ALA A 604
ILE A 300
ILE A 292
PRO A 642
 None
 0.97A 1hxbB-1qhgA:
undetectable		 1hxbB-1qhgA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 8 SER A 590
PHE A 637
ASN A 639
LEU A 591
 None
 1.01A 1lhvA-1qhgA:
undetectable		 1lhvA-1qhgA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 11 ALA A  33
GLY A  32
GLU A 283
ASN A  13
GLU A 571
 None
None
None
None
ATP  A 726 ( 3.8A)
 1.27A 1n6cA-1qhgA:
undetectable		 1n6cA-1qhgA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 5 TYR A 387
LYS A 385
VAL A 559
ILE A 380
 None
 1.35A 1opjA-1qhgA:
0.0		 1opjA-1qhgA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 239
LYS A 238
TYR A 213
TRP A  88
LEU A  60
 None
 1.43A 1sv5A-1qhgA:
0.0		 1sv5A-1qhgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 296
ALA A 295
GLN A 294
LEU A 645
LEU A 617
 None
 1.06A 1xiuB-1qhgA:
undetectable		 1xiuB-1qhgA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A  12
LEU A  41
ARG A  39
LEU A 282
ILE A  29
 None
None
ATP  A 726 (-3.7A)
None
None
 1.07A 1yi4A-1qhgA:
undetectable		 1yi4A-1qhgA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 1.06A 2aylA-1qhgA:
1.3		 2aylA-1qhgA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 1.04A 2aylB-1qhgA:
1.3		 2aylB-1qhgA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 8 ARG A 339
ALA A 326
GLY A 579
ILE A 578
LEU A 322
 None
 1.10A 2o4nB-1qhgA:
undetectable		 2o4nB-1qhgA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 241
ASP A 273
TYR A 233
 None
 0.66A 2yvlB-1qhgA:
2.8		 2yvlB-1qhgA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 4 VAL A  97
ASP A 191
LEU A 185
ARG A 101
 None
 1.49A 2ziaA-1qhgA:
1.3		 2ziaA-1qhgA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 638
ALA A 604
ILE A 300
ILE A 292
PRO A 642
 None
 0.96A 3el5A-1qhgA:
undetectable		 3el5A-1qhgA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 7 GLY A 250
GLN A 254
ASP A 223
ILE A 222
 None
ATP  A 726 ( 4.7A)
None
None
 0.89A 3fi0P-1qhgA:
undetectable		 3fi0P-1qhgA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 4 LEU A 570
ALA A 355
VAL A 575
PRO A 573
 None
 1.12A 3gv1B-1qhgA:
undetectable		 3gv1B-1qhgA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 638
ALA A 604
ILE A 300
ILE A 292
PRO A 642
 None
 0.87A 3k4vD-1qhgA:
undetectable		 3k4vD-1qhgA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 0.97A 3n8wA-1qhgA:
undetectable		 3n8wA-1qhgA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 1.02A 3n8zA-1qhgA:
undetectable		 3n8zA-1qhgA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 0.99A 3n8zB-1qhgA:
1.7		 3n8zB-1qhgA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 TYR A 213
ILE A 196
PHE A  92
THR A 199
ILE A 200
 None
 1.28A 3ndiA-1qhgA:
2.9		 3ndiA-1qhgA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 638
ALA A 604
ILE A 300
ILE A 292
PRO A 642
 None
 0.98A 3nduB-1qhgA:
undetectable		 3nduB-1qhgA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 638
ALA A 604
ILE A 300
ILE A 292
PRO A 642
 None
 0.92A 3nduD-1qhgA:
undetectable		 3nduD-1qhgA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 1.10A 3pghD-1qhgA:
0.0		 3pghD-1qhgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A 567
ILE A 321
LEU A 577
ILE A 300
ILE A 311
 None
 0.90A 3prsA-1qhgA:
undetectable		 3prsA-1qhgA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A  98
ARG A  73
ASP A  86
 None
 0.73A 3wipG-1qhgA:
undetectable
3wipH-1qhgA:
undetectable		 3wipG-1qhgA:
15.38
3wipH-1qhgA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 512
ARG A 508
GLY A 492
TYR A 493
 None
 0.96A 4cp3A-1qhgA:
undetectable
4cp3B-1qhgA:
undetectable		 4cp3A-1qhgA:
11.52
4cp3B-1qhgA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 617
LEU A 577
LEU A 564
ILE A 321
VAL A 299
 None
 1.20A 4f4dB-1qhgA:
2.4		 4f4dB-1qhgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 8 ALA A 150
LEU A 156
THR A 147
SER A 174
 None
 0.95A 4ikkA-1qhgA:
undetectable
4ikkB-1qhgA:
undetectable		 4ikkA-1qhgA:
11.86
4ikkB-1qhgA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 6 ARG A 111
ASP A 103
ASP A 105
ARG A 106
 None
 1.25A 4kcnB-1qhgA:
undetectable		 4kcnB-1qhgA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 617
LEU A 577
LEU A 564
ILE A 321
VAL A 299
 None
 1.31A 4mk4A-1qhgA:
3.6		 4mk4A-1qhgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 4 LEU A 531
SER A 479
LEU A 474
LEU A 399
 None
 1.03A 4n09A-1qhgA:
undetectable		 4n09A-1qhgA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 638
ALA A 604
ILE A 300
ILE A 292
PRO A 642
 None
 1.06A 4njuA-1qhgA:
undetectable		 4njuA-1qhgA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OMW_D_TE4D202_1
(BETA-LACTOGLOBULIN)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 497
GLU A 391
ASN A 511
ALA A 362
GLU A 510
 None
 1.30A 4omwD-1qhgA:
undetectable		 4omwD-1qhgA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 6 THR A 481
GLU A 523
THR A 519
THR A 624
 None
 1.04A 4pgfA-1qhgA:
undetectable		 4pgfA-1qhgA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 248
ILE A 280
LEU A 282
GLY A  36
GLN A  16
 None
None
None
ATP  A 726 (-3.4A)
ATP  A 726 (-3.3A)
 0.97A 4r3aB-1qhgA:
undetectable		 4r3aB-1qhgA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 1.05A 4rs0A-1qhgA:
undetectable		 4rs0A-1qhgA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 301
ARG A 306
GLN A 294
 None
 0.87A 4rtbA-1qhgA:
undetectable		 4rtbA-1qhgA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 4 LEU A 441
LEU A 445
GLY A 446
GLU A 447
 None
 1.09A 5hhjA-1qhgA:
undetectable		 5hhjA-1qhgA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 5 GLU A 523
THR A 519
GLU A 485
LEU A 474
 None
 1.24A 5hm8A-1qhgA:
undetectable		 5hm8A-1qhgA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 5 GLU A 523
THR A 519
GLU A 485
LEU A 474
 None
 1.24A 5hm8B-1qhgA:
undetectable		 5hm8B-1qhgA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 5 GLU A 523
THR A 519
GLU A 485
LEU A 474
 None
 1.24A 5hm8C-1qhgA:
undetectable		 5hm8C-1qhgA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 5 GLU A 523
THR A 519
GLU A 485
LEU A 474
 None
 1.23A 5hm8D-1qhgA:
undetectable		 5hm8D-1qhgA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 5 GLU A 523
THR A 519
GLU A 485
LEU A 474
 None
 1.24A 5hm8E-1qhgA:
undetectable		 5hm8E-1qhgA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 5 GLU A 523
THR A 519
GLU A 485
LEU A 474
 None
 1.24A 5hm8F-1qhgA:
undetectable		 5hm8F-1qhgA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 5 GLU A 523
THR A 519
GLU A 485
LEU A 474
 None
 1.24A 5hm8H-1qhgA:
undetectable		 5hm8H-1qhgA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A 632
GLU A 582
LEU A 577
LEU A 564
THR A 563
 None
 1.05A 5hnwB-1qhgA:
undetectable		 5hnwB-1qhgA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A 632
GLU A 582
LEU A 577
LEU A 564
THR A 563
 None
 1.02A 5hnxB-1qhgA:
undetectable		 5hnxB-1qhgA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A 632
GLU A 582
LEU A 577
LEU A 564
THR A 563
 None
 1.05A 5hnyB-1qhgA:
undetectable		 5hnyB-1qhgA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 1.12A 5ikqB-1qhgA:
undetectable		 5ikqB-1qhgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 1.13A 5ikrA-1qhgA:
undetectable		 5ikrA-1qhgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 1.11A 5ikrB-1qhgA:
0.0		 5ikrB-1qhgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		6 / 12 VAL A  40
LEU A  41
ALA A  68
GLY A 250
ALA A  31
LEU A 282
 None
 1.09A 5kirA-1qhgA:
undetectable		 5kirA-1qhgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 235
PHE A 203
ASP A 204
HIS A 211
 None
 1.07A 5om3A-1qhgA:
0.0
5om3B-1qhgA:
0.0		 5om3A-1qhgA:
9.52
5om3B-1qhgA:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 1qhg ATP-DEPENDENT
HELICASE PCRA
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 602
ARG A 359
ARG A 260
 None
 0.99A 5vcgA-1qhgA:
undetectable		 5vcgA-1qhgA:
21.80