SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qhm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 8 ALA A1554
GLU A1452
LEU A1443
LEU A1470
 None
 0.91A 1ereE-1qhmA:
undetectable		 1ereE-1qhmA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 8 ALA A1554
GLU A1452
LEU A1443
LEU A1470
 None
 0.89A 1ereF-1qhmA:
undetectable		 1ereF-1qhmA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 6 SER A1280
THR A1281
PHE A1383
GLU A1336
 None
 0.97A 1icuA-1qhmA:
undetectable
1icuB-1qhmA:
undetectable		 1icuA-1qhmA:
16.59
1icuB-1qhmA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 6 PHE A1383
GLU A1336
SER A1280
THR A1281
 None
 0.93A 1icuA-1qhmA:
undetectable
1icuB-1qhmA:
undetectable		 1icuA-1qhmA:
16.59
1icuB-1qhmA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 6 SER A1280
THR A1281
PHE A1383
GLU A1336
 None
 0.96A 1icuC-1qhmA:
undetectable
1icuD-1qhmA:
undetectable		 1icuC-1qhmA:
16.59
1icuD-1qhmA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 6 SER A1280
THR A1281
PHE A1383
GLU A1336
 None
 0.99A 1kqbA-1qhmA:
undetectable
1kqbB-1qhmA:
undetectable		 1kqbA-1qhmA:
15.30
1kqbB-1qhmA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 6 SER A1280
THR A1281
PHE A1383
GLU A1336
 None
 0.97A 1kqbC-1qhmA:
undetectable
1kqbD-1qhmA:
undetectable		 1kqbC-1qhmA:
15.30
1kqbD-1qhmA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 6 PHE A1383
GLU A1336
SER A1280
THR A1281
 None
 0.99A 1kqbC-1qhmA:
undetectable
1kqbD-1qhmA:
undetectable		 1kqbC-1qhmA:
15.30
1kqbD-1qhmA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 6 LEU A1536
LEU A1604
MET A1483
LEU A1438
 None
 1.00A 1z95A-1qhmA:
undetectable		 1z95A-1qhmA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 7 ARG A1520
ALA A1508
ASP A1502
TYR A1506
 None
 1.12A 2e5dA-1qhmA:
2.6
2e5dB-1qhmA:
undetectable		 2e5dA-1qhmA:
22.10
2e5dB-1qhmA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 7 ARG A1595
ALA A1508
ASP A1502
TYR A1506
 None
 1.16A 2e5dA-1qhmA:
2.6
2e5dB-1qhmA:
undetectable		 2e5dA-1qhmA:
22.10
2e5dB-1qhmA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 7 ASP A1502
TYR A1506
ARG A1520
ALA A1508
 None
 1.13A 2e5dA-1qhmA:
2.6
2e5dB-1qhmA:
undetectable		 2e5dA-1qhmA:
22.10
2e5dB-1qhmA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 7 ASP A1502
TYR A1506
ARG A1595
ALA A1508
 None
 1.16A 2e5dA-1qhmA:
2.6
2e5dB-1qhmA:
undetectable		 2e5dA-1qhmA:
22.10
2e5dB-1qhmA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 ALA A1248
GLN A1256
ASP A1180
GLY A1261
LEU A1263
 None
 1.33A 2nv4B-1qhmA:
0.0		 2nv4B-1qhmA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 7 ILE A1156
ARG A1160
PRO A1599
GLY A1433
 None
 0.88A 2pnjB-1qhmA:
undetectable		 2pnjB-1qhmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		3 / 3 ASP A1403
ASN A1401
THR A1372
 None
 0.63A 2pymB-1qhmA:
0.0		 2pymB-1qhmA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		3 / 3 ASP A1403
ASN A1401
THR A1372
 None
 0.63A 2q63B-1qhmA:
undetectable		 2q63B-1qhmA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		6 / 12 ALA A1554
GLU A1452
LEU A1553
LEU A1443
LEU A1470
PRO A1464
 None
 1.46A 2qxsA-1qhmA:
undetectable		 2qxsA-1qhmA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		6 / 12 ALA A1554
GLU A1452
LEU A1553
LEU A1443
LEU A1470
PRO A1464
 None
 1.39A 2qxsB-1qhmA:
undetectable		 2qxsB-1qhmA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		3 / 3 SER A1079
HIS A1144
ASP A1502
 None
 0.63A 2wa2B-1qhmA:
undetectable		 2wa2B-1qhmA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 6 ASP A1412
ARG A1278
VAL A1425
ILE A1424
 None
 1.18A 2yfbB-1qhmA:
3.3		 2yfbB-1qhmA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 7 PHE A1432
GLY A1173
ASP A1330
TRP A1333
 None
 1.26A 3aruA-1qhmA:
undetectable		 3aruA-1qhmA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		3 / 3 ARG A1026
THR A1258
THR A1350
 None
 0.69A 3k2hB-1qhmA:
undetectable		 3k2hB-1qhmA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 11 ILE A1156
LEU A1168
LEU A1494
THR A1492
ALA A1493
 None
 1.18A 3kw2A-1qhmA:
0.8		 3kw2A-1qhmA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 11 ILE A1156
LEU A1168
LEU A1494
THR A1492
ALA A1493
 None
 1.19A 3kw2B-1qhmA:
undetectable		 3kw2B-1qhmA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 ALA A1554
GLU A1452
LEU A1443
ILE A1559
LEU A1470
 None
 1.03A 3olsB-1qhmA:
undetectable		 3olsB-1qhmA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.07A 3uboB-1qhmA:
undetectable		 3uboB-1qhmA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 6 ASP A1306
ILE A1255
THR A1359
PHE A1356
 None
 0.84A 4acbC-1qhmA:
2.4		 4acbC-1qhmA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.00A 4e3aA-1qhmA:
undetectable		 4e3aA-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 5 ALA A1554
ILE A1465
LEU A1470
ASN A1447
 None
 1.11A 4g19A-1qhmA:
undetectable		 4g19A-1qhmA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.04A 4jkuB-1qhmA:
undetectable		 4jkuB-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.03A 4k8pA-1qhmA:
undetectable		 4k8pA-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.02A 4k8pB-1qhmA:
undetectable		 4k8pB-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.03A 4k8tA-1qhmA:
undetectable		 4k8tA-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.03A 4k8tB-1qhmA:
undetectable		 4k8tB-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.02A 4k93A-1qhmA:
undetectable		 4k93A-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.02A 4k93B-1qhmA:
undetectable		 4k93B-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.02A 4k9cA-1qhmA:
undetectable		 4k9cA-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.02A 4k9cB-1qhmA:
undetectable		 4k9cB-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.02A 4k9iA-1qhmA:
undetectable		 4k9iA-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.03A 4k9iB-1qhmA:
undetectable		 4k9iB-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.04A 4kadA-1qhmA:
undetectable		 4kadA-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.04A 4kadB-1qhmA:
undetectable		 4kadB-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.02A 4lbxA-1qhmA:
undetectable		 4lbxA-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.02A 4lbxB-1qhmA:
undetectable		 4lbxB-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.03A 4lc4A-1qhmA:
undetectable		 4lc4A-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1277
THR A1281
LEU A1348
THR A1258
ASP A1180
 None
 1.02A 4lc4B-1qhmA:
undetectable		 4lc4B-1qhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		3 / 3 ALA A1248
GLN A1020
GLY A1017
 None
 0.61A 4odoC-1qhmA:
undetectable		 4odoC-1qhmA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 ASN A1024
VAL A1023
GLY A1426
ILE A1178
GLN A1430
 None
 1.40A 4xucA-1qhmA:
2.0		 4xucA-1qhmA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 7 GLU A1253
LEU A1053
ILE A1096
MET A1304
 None
 0.90A 4xumA-1qhmA:
undetectable		 4xumA-1qhmA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 7 ARG A1346
ARG A1278
ILE A1029
TYR A1033
 None
 1.21A 5a06B-1qhmA:
undetectable		 5a06B-1qhmA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 7 ILE A1392
VAL A1349
ILE A1373
PHE A1354
 None
 1.00A 5hieC-1qhmA:
0.0		 5hieC-1qhmA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1271
MET A1274
ARG A1520
GLY A1113
SER A1505
 None
 1.19A 5hikA-1qhmA:
undetectable		 5hikA-1qhmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		3 / 3 LYS A1194
GLN A1020
ASN A1021
 None
 0.98A 5l2tA-1qhmA:
undetectable		 5l2tA-1qhmA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		3 / 3 MET A1483
GLU A1582
ARG A1583
 None
 1.13A 5tjyA-1qhmA:
undetectable		 5tjyA-1qhmA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 ALA A1554
GLU A1452
LEU A1443
ILE A1559
LEU A1470
 None
 1.01A 5toaA-1qhmA:
undetectable		 5toaA-1qhmA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 HIS A1498
VAL A1148
LEU A1486
PHE A1584
GLY A1433
 None
 1.32A 6brdA-1qhmA:
undetectable		 6brdA-1qhmA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		5 / 12 GLY A1231
PHE A1317
ILE A1332
GLY A1271
LEU A1510
 None
 1.07A 6e8qA-1qhmA:
undetectable		 6e8qA-1qhmA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		3 / 3 VAL A1420
ALA A1417
GLN A1430
 None
 0.65A 6gb9A-1qhmA:
undetectable		 6gb9A-1qhmA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 6 GLY A1339
LEU A1374
VAL A1285
PHE A1028
 None
 0.92A 6h7lA-1qhmA:
3.3		 6h7lA-1qhmA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1qhm PYRUVATE
FORMATE-LYASE
(Escherichia
coli) 		4 / 6 GLY A1339
LEU A1374
VAL A1285
PHE A1028
 None
 0.92A 6h7lB-1qhmA:
undetectable		 6h7lB-1qhmA:
7.81