SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qhq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		3 / 3 ALA A  23
VAL A  21
TRP A  59
 None
 0.87A 1av2A-1qhqA:
undetectable
1av2B-1qhqA:
undetectable		 1av2A-1qhqA:
6.43
1av2B-1qhqA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		3 / 3 TRP A  59
ALA A  23
VAL A  21
 None
 0.82A 1av2C-1qhqA:
undetectable
1av2D-1qhqA:
undetectable		 1av2C-1qhqA:
6.43
1av2D-1qhqA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		4 / 4 HIS A  57
CYH A 122
HIS A 127
MET A 132
 CU  A 141 ( 3.1A)
CU  A 141 ( 2.1A)
CU  A 141 (-3.1A)
CU  A 141 ( 2.8A)
 0.39A 1oe1A-1qhqA:
5.3		 1oe1A-1qhqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		4 / 5 HIS A  57
CYH A 122
HIS A 127
MET A 132
 CU  A 141 ( 3.1A)
CU  A 141 ( 2.1A)
CU  A 141 (-3.1A)
CU  A 141 ( 2.8A)
 0.39A 1oe2A-1qhqA:
9.6		 1oe2A-1qhqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		4 / 4 HIS A  57
CYH A 122
HIS A 127
MET A 132
 CU  A 141 ( 3.1A)
CU  A 141 ( 2.1A)
CU  A 141 (-3.1A)
CU  A 141 ( 2.8A)
 0.42A 1oe3A-1qhqA:
5.2		 1oe3A-1qhqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		3 / 3 ALA A  23
VAL A  21
TRP A  59
 None
 0.86A 1w5uA-1qhqA:
undetectable
1w5uB-1qhqA:
undetectable		 1w5uA-1qhqA:
6.43
1w5uB-1qhqA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		3 / 3 TRP A  59
ALA A  23
VAL A  21
 None
 0.85A 1w5uA-1qhqA:
undetectable
1w5uB-1qhqA:
undetectable		 1w5uA-1qhqA:
6.43
1w5uB-1qhqA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		4 / 4 HIS A  57
CYH A 122
HIS A 127
MET A 132
 CU  A 141 ( 3.1A)
CU  A 141 ( 2.1A)
CU  A 141 (-3.1A)
CU  A 141 ( 2.8A)
 0.46A 2fqdA-1qhqA:
4.2		 2fqdA-1qhqA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		4 / 4 HIS A  57
CYH A 122
HIS A 127
MET A 132
 CU  A 141 ( 3.1A)
CU  A 141 ( 2.1A)
CU  A 141 (-3.1A)
CU  A 141 ( 2.8A)
 0.43A 2fqeA-1qhqA:
4.2		 2fqeA-1qhqA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		4 / 4 HIS A  57
CYH A 122
HIS A 127
MET A 132
 CU  A 141 ( 3.1A)
CU  A 141 ( 2.1A)
CU  A 141 (-3.1A)
CU  A 141 ( 2.8A)
 0.40A 2fqfA-1qhqA:
3.7		 2fqfA-1qhqA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		4 / 4 HIS A  57
CYH A 122
HIS A 127
MET A 132
 CU  A 141 ( 3.1A)
CU  A 141 ( 2.1A)
CU  A 141 (-3.1A)
CU  A 141 ( 2.8A)
 0.43A 2fqgA-1qhqA:
3.7		 2fqgA-1qhqA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		3 / 3 ALA A  23
VAL A  21
TRP A  59
 None
 0.87A 2izqA-1qhqA:
undetectable
2izqB-1qhqA:
undetectable		 2izqA-1qhqA:
6.43
2izqB-1qhqA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		3 / 3 TRP A  59
ALA A  23
VAL A  21
 None
 0.98A 2izqC-1qhqA:
undetectable
2izqD-1qhqA:
undetectable		 2izqC-1qhqA:
6.43
2izqD-1qhqA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		3 / 3 LEU A  37
PRO A  38
ARG A  44
 None
None
SO4  A 143 (-3.4A)
 0.57A 2qd5A-1qhqA:
undetectable		 2qd5A-1qhqA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		4 / 4 HIS A  57
CYH A 122
HIS A 127
MET A 132
 CU  A 141 ( 3.1A)
CU  A 141 ( 2.1A)
CU  A 141 (-3.1A)
CU  A 141 ( 2.8A)
 0.41A 2xxgA-1qhqA:
9.5		 2xxgA-1qhqA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		4 / 5 HIS A  57
CYH A 122
HIS A 127
MET A 132
 CU  A 141 ( 3.1A)
CU  A 141 ( 2.1A)
CU  A 141 (-3.1A)
CU  A 141 ( 2.8A)
 0.41A 2xxgC-1qhqA:
8.5		 2xxgC-1qhqA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		3 / 3 TRP A  59
ALA A  23
VAL A  21
 None
 0.98A 3l8lC-1qhqA:
undetectable
3l8lD-1qhqA:
undetectable		 3l8lC-1qhqA:
6.43
3l8lD-1qhqA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		4 / 4 HIS A  57
CYH A 122
HIS A 127
MET A 132
 CU  A 141 ( 3.1A)
CU  A 141 ( 2.1A)
CU  A 141 (-3.1A)
CU  A 141 ( 2.8A)
 0.42A 4ef3A-1qhqA:
4.3		 4ef3A-1qhqA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		3 / 3 LEU A  37
PRO A  38
ARG A  44
 None
None
SO4  A 143 (-3.4A)
 0.72A 4klrB-1qhqA:
undetectable		 4klrB-1qhqA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1qhq PROTEIN (AURACYANIN)
(Chloroflexus
aurantiacus) 		4 / 8 PRO A 113
LEU A  94
VAL A  68
TYR A 118
 None
None
SO4  A 144 (-3.7A)
None
 0.92A 4pwdA-1qhqA:
undetectable		 4pwdA-1qhqA:
12.41