SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qhx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		5 / 11 ILE A  89
ASP A  92
GLY A  35
PHE A  34
VAL A  20
 None
MG  A 500 (-3.1A)
None
None
None
 1.33A 1axwB-1qhxA:
undetectable		 1axwB-1qhxA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		5 / 12 ILE A   6
LEU A   8
VAL A 119
ILE A  19
ILE A  90
 None
 0.83A 1oipA-1qhxA:
undetectable		 1oipA-1qhxA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QHS_A_CLMA888_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		5 / 5 PRO A  44
LYS A  46
MET A  47
ALA A  50
GLU A  67
 None
 0.83A 1qhsA-1qhxA:
33.8		 1qhsA-1qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		11 / 12 SER A  12
VAL A  36
ILE A  40
ILE A  54
PHE A  56
ILE A  64
PHE A  68
VAL A  94
LEU A  96
MET A 140
GLN A 144
 ATP  A 501 (-2.6A)
None
None
None
None
None
None
None
None
None
None
 0.59A 1qhsA-1qhxA:
33.8		 1qhsA-1qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		11 / 12 VAL A  36
ILE A  40
ILE A  54
PHE A  56
ILE A  64
PHE A  68
VAL A  94
LEU A  96
ARG A 136
MET A 140
GLN A 144
 None
None
None
None
None
None
None
None
ATP  A 501 (-1.8A)
None
None
 0.81A 1qhsA-1qhxA:
33.8		 1qhsA-1qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		5 / 6 PRO A  44
LYS A  46
ALA A  50
GLU A  51
GLU A  67
 None
 1.05A 1qhyA-1qhxA:
34.4		 1qhyA-1qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		5 / 6 PRO A  44
LYS A  46
MET A  47
ALA A  50
GLU A  67
 None
 0.22A 1qhyA-1qhxA:
34.4		 1qhyA-1qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		6 / 12 SER A  12
ILE A  54
ASP A  93
VAL A  94
MET A 140
GLN A 144
 ATP  A 501 (-2.6A)
None
None
None
None
None
 1.13A 1qhyA-1qhxA:
34.4		 1qhyA-1qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		11 / 12 SER A  12
VAL A  36
ILE A  40
ILE A  54
PHE A  56
ILE A  64
ASP A  93
VAL A  94
LEU A  96
MET A 140
GLN A 144
 ATP  A 501 (-2.6A)
None
None
None
None
None
None
None
None
None
None
 0.41A 1qhyA-1qhxA:
34.4		 1qhyA-1qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		6 / 12 SER A  12
VAL A  36
ILE A  64
VAL A  94
MET A 140
GLN A 144
 ATP  A 501 (-2.6A)
None
None
None
None
None
 1.35A 1qhyA-1qhxA:
34.4		 1qhyA-1qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		11 / 12 VAL A  36
ILE A  40
ILE A  54
PHE A  56
ILE A  64
ASP A  93
VAL A  94
LEU A  96
ARG A 136
MET A 140
GLN A 144
 None
None
None
None
None
None
None
None
ATP  A 501 (-1.8A)
None
None
 0.67A 1qhyA-1qhxA:
34.4		 1qhyA-1qhxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		5 / 12 VAL A  36
ILE A  54
ASP A  93
VAL A  94
GLN A 144
 None
 0.79A 1qhyA-1qhxA:
34.4		 1qhyA-1qhxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		5 / 12 GLY A  10
GLU A 157
HIS A 149
PHE A  95
VAL A  94
 None
 1.41A 1qu3A-1qhxA:
undetectable		 1qu3A-1qhxA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		5 / 8 ALA A  70
GLY A  52
GLY A  53
ILE A  54
PRO A  44
 None
 1.23A 1sguA-1qhxA:
undetectable		 1sguA-1qhxA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		3 / 3 GLU A 153
GLU A 157
LEU A 115
 None
 0.69A 1v8bB-1qhxA:
undetectable		 1v8bB-1qhxA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		4 / 6 PHE A  68
ILE A  64
VAL A  62
PHE A  56
 None
 0.91A 2cizA-1qhxA:
0.0		 2cizA-1qhxA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		5 / 8 ARG A  88
ILE A  89
ASP A  93
GLY A  35
PHE A  34
 None
 1.46A 2tsrB-1qhxA:
undetectable		 2tsrB-1qhxA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		5 / 12 GLU A  72
VAL A 114
ASP A  93
ILE A   7
ASN A   9
 None
 1.39A 3jayA-1qhxA:
3.6		 3jayA-1qhxA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		5 / 12 GLU A  72
VAL A 114
ASP A  93
ILE A   7
ASN A   9
 None
 1.29A 3jb3A-1qhxA:
1.9		 3jb3A-1qhxA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		4 / 8 ASP A 155
GLU A 153
GLN A 102
VAL A 109
 None
 1.16A 4lnwA-1qhxA:
undetectable		 4lnwA-1qhxA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		5 / 8 ALA A 171
ALA A 169
ILE A 172
ALA A  14
LEU A   8
 None
None
None
ATP  A 501 (-4.2A)
None
 1.26A 4v1fA-1qhxA:
undetectable
4v1fB-1qhxA:
undetectable		 4v1fA-1qhxA:
19.10
4v1fB-1qhxA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		5 / 9 LEU A 112
VAL A 109
VAL A  80
ILE A  91
ILE A   7
 None
 1.22A 5yf9X-1qhxA:
undetectable		 5yf9X-1qhxA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
(Streptomyces
venezuelae) 		3 / 3 TRP A 116
GLU A 153
GLU A 103
 None
 0.99A 6fhwA-1qhxA:
undetectable		 6fhwA-1qhxA:
21.76