SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_B_MTXB301_1
(PTERIDINE REDUCTASE)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 PRO A  31
ASP A  49
TYR A  15
TYR A  34
HIS A  21
 None
 1.46A 1e7wB-1qk1A:
undetectable		 1e7wB-1qk1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 125
ILE A 222
TRP A 223
 PO4  A 400 (-3.4A)
None
None
 1.02A 1nodB-1qk1A:
undetectable		 1nodB-1qk1A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU A 312
VAL A 290
GLY A 289
LEU A 355
 None
 0.93A 1s1xA-1qk1A:
2.7		 1s1xA-1qk1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 HIS A 102
ASN A 269
GLY A 283
TYR A 274
 None
 1.02A 2f6dA-1qk1A:
undetectable		 2f6dA-1qk1A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 125
ILE A 222
TRP A 223
 PO4  A 400 (-3.4A)
None
None
 1.00A 2nodB-1qk1A:
undetectable		 2nodB-1qk1A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 312
LEU A 334
ARG A 336
LEU A 294
PHE A 303
 None
 1.16A 2oz7A-1qk1A:
undetectable		 2oz7A-1qk1A:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 THR A  66
VAL A  67
CYH A 278
SER A 280
 None
 0.40A 3b6rB-1qk1A:
50.0		 3b6rB-1qk1A:
66.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ILE A  88
HIS A  92
TYR A  77
GLY A 283
 None
 1.14A 3b9mA-1qk1A:
0.0		 3b9mA-1qk1A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 125
ILE A 222
TRP A 223
 PO4  A 400 (-3.4A)
None
None
 0.90A 3e68A-1qk1A:
undetectable		 3e68A-1qk1A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 125
ILE A 222
TRP A 223
 PO4  A 400 (-3.4A)
None
None
 0.95A 3e6tB-1qk1A:
undetectable		 3e6tB-1qk1A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gB-1qk1A:
undetectable		 3j6gB-1qk1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gD-1qk1A:
undetectable		 3j6gD-1qk1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gF-1qk1A:
0.2		 3j6gF-1qk1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gH-1qk1A:
0.0		 3j6gH-1qk1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gJ-1qk1A:
undetectable		 3j6gJ-1qk1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gL-1qk1A:
undetectable		 3j6gL-1qk1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gN-1qk1A:
undetectable		 3j6gN-1qk1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gP-1qk1A:
undetectable		 3j6gP-1qk1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gR-1qk1A:
undetectable		 3j6gR-1qk1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASN A  23
MET A  25
LEU A  83
LEU A  18
 None
 1.24A 3nk2X-1qk1A:
undetectable		 3nk2X-1qk1A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CUT_A_TYLA2971_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 VAL A 290
VAL A 121
ASN A 353
ILE A 349
 None
 1.30A 4cutA-1qk1A:
0.1		 4cutA-1qk1A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 357
ARG A 361
ASP A 117
 None
 0.66A 4fp9A-1qk1A:
undetectable		 4fp9A-1qk1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 357
ARG A 361
ASP A 117
 None
 0.65A 4fp9C-1qk1A:
undetectable		 4fp9C-1qk1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 357
ARG A 361
ASP A 117
 None
 0.69A 4fp9F-1qk1A:
undetectable		 4fp9F-1qk1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 357
ARG A 361
TYR A 354
 None
 0.93A 5a7mA-1qk1A:
undetectable		 5a7mA-1qk1A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 357
ARG A 361
TYR A 354
 None
 0.91A 5a7mB-1qk1A:
undetectable		 5a7mB-1qk1A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASP A  73
TRP A  46
THR A  76
THR A  41
 None
 0.90A 5b6iA-1qk1A:
undetectable		 5b6iA-1qk1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ASP A  73
TRP A  46
THR A  76
THR A  41
 None
 0.91A 5b6iB-1qk1A:
undetectable		 5b6iB-1qk1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 351
LEU A 307
ASN A 353
ARG A 361
LEU A 297
 None
 1.50A 5emlA-1qk1A:
undetectable		 5emlA-1qk1A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLU A 227
LEU A 137
GLY A 129
ASN A 281
LEU A 282
 None
 1.32A 5kbwA-1qk1A:
undetectable		 5kbwA-1qk1A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLU A 227
LEU A 137
GLY A 129
ASN A 281
LEU A 282
 None
 1.33A 5kc4E-1qk1A:
undetectable		 5kc4E-1qk1A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A 214
ASN A 215
ALA A 165
 None
 0.80A 5n4tB-1qk1A:
0.7		 5n4tB-1qk1A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 MET A 202
ASP A 228
ARG A  91
 None
 1.03A 5z6jA-1qk1A:
0.0		 5z6jA-1qk1A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 255
LEU A 160
GLU A 256
GLY A 251
LEU A 157
 None
 0.99A 6f6iA-1qk1A:
undetectable
6f6iB-1qk1A:
0.0		 6f6iA-1qk1A:
13.08
6f6iB-1qk1A:
12.20