SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qlb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 5 LYS A 500
LEU A 497
GLU A 461
LEU A 494
 None
 1.16A 1eta1-1qlbA:
0.0		 1eta1-1qlbA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 5 LYS A 500
LEU A 497
GLU A 461
LEU A 494
 None
 1.15A 1eta2-1qlbA:
0.0		 1eta2-1qlbA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 6 LYS A 500
LEU A 497
GLU A 461
LEU A 494
 None
 1.16A 1etb1-1qlbA:
undetectable		 1etb1-1qlbA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 6 ALA A  96
SER A 390
LEU A 100
TRP A 103
 None
 1.02A 1gahA-1qlbA:
undetectable		 1gahA-1qlbA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		4 / 8 ARG B 178
VAL B 118
SER B 115
ASN B 112
 None
 1.17A 1hwiB-1qlbB:
0.0		 1hwiB-1qlbB:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 7 MET A 399
TYR A 370
SER A 411
ALA A 416
 None
FAD  A1656 (-4.3A)
None
None
 0.91A 1k5qA-1qlbA:
undetectable
1k5qB-1qlbA:
undetectable		 1k5qA-1qlbA:
15.51
1k5qB-1qlbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 7 CYH A 150
THR A 152
SER A 138
LEU A  15
 None
 0.93A 1qcaA-1qlbA:
undetectable		 1qcaA-1qlbA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 GLU A 412
TRP A 397
LYS A 471
 None
 1.35A 1qu2A-1qlbA:
3.1		 1qu2A-1qlbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 8 ALA A  20
GLY A  13
GLY A  12
ILE A  11
ALA A 395
 None
FAD  A1656 (-3.4A)
FAD  A1656 (-3.3A)
None
None
 0.86A 1sguA-1qlbA:
undetectable		 1sguA-1qlbA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 12 ALA A  16
GLY A  14
GLY A  13
GLY A 374
ARG A 376
 FAD  A1656 (-3.4A)
FAD  A1656 (-3.5A)
FAD  A1656 (-3.4A)
CA  A1658 ( 4.1A)
None
 0.96A 1sqfA-1qlbA:
undetectable		 1sqfA-1qlbA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 8 TYR A 580
THR A 577
CYH A 532
LEU A 241
 None
 1.18A 1uw6A-1qlbA:
undetectable
1uw6B-1qlbA:
undetectable		 1uw6A-1qlbA:
15.29
1uw6B-1qlbA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 8 TYR A 580
THR A 577
CYH A 532
LEU A 241
 None
 1.18A 1uw6D-1qlbA:
undetectable
1uw6E-1qlbA:
undetectable		 1uw6D-1qlbA:
15.29
1uw6E-1qlbA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 8 TYR A 580
THR A 577
CYH A 532
LEU A 241
 None
 1.18A 1uw6G-1qlbA:
undetectable
1uw6H-1qlbA:
undetectable		 1uw6G-1qlbA:
15.29
1uw6H-1qlbA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 8 TYR A 580
THR A 577
CYH A 532
LEU A 241
 None
 1.19A 1uw6P-1qlbA:
undetectable
1uw6Q-1qlbA:
undetectable		 1uw6P-1qlbA:
15.29
1uw6Q-1qlbA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 8 LEU A 241
TYR A 580
THR A 577
CYH A 532
 None
 1.24A 1uw6P-1qlbA:
undetectable
1uw6T-1qlbA:
undetectable		 1uw6P-1qlbA:
15.29
1uw6T-1qlbA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 ASP A 302
ARG A 306
ASP A  78
 None
 0.87A 1vptA-1qlbA:
undetectable		 1vptA-1qlbA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 6 SER A 390
ILE A 375
ALA A 240
ALA A 181
 None
None
None
FAD  A1656 (-3.8A)
 0.96A 1w0gA-1qlbA:
0.0		 1w0gA-1qlbA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 ASP A 329
VAL A 364
PRO A 258
 None
 0.76A 2avvA-1qlbA:
undetectable		 2avvA-1qlbA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 12 LYS A  27
GLU A 422
GLY A 421
ALA A  20
ALA A  16
 None
None
None
None
FAD  A1656 (-3.4A)
 1.16A 2bm9C-1qlbA:
undetectable		 2bm9C-1qlbA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		6 / 12 LEU A  29
LYS A  27
GLU A 422
GLY A 421
ALA A  20
ALA A  16
 None
None
None
None
None
FAD  A1656 (-3.4A)
 1.43A 2br4E-1qlbA:
undetectable		 2br4E-1qlbA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 LYS A 336
ASP A 356
CYH A 349
 None
 1.38A 2br4F-1qlbA:
undetectable		 2br4F-1qlbA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		6 / 10 ALA A  21
THR A  24
ALA A  23
ALA A  20
VAL A  33
GLY A 172
 None
 1.36A 2f16K-1qlbA:
undetectable
2f16L-1qlbA:
undetectable		 2f16K-1qlbA:
15.90
2f16L-1qlbA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		6 / 10 ALA A  21
THR A  24
ALA A  23
ALA A  20
VAL A  33
GLY A 172
 None
 1.37A 2f16Y-1qlbA:
undetectable
2f16Z-1qlbA:
undetectable		 2f16Y-1qlbA:
15.90
2f16Z-1qlbA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		6 / 12 GLY A 459
GLY A 505
ILE A 506
PRO A 524
VAL A 523
ILE A 466
 None
 1.32A 2fxeA-1qlbA:
undetectable		 2fxeA-1qlbA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 ARG A 139
VAL A 105
THR A 159
 None
 0.87A 2nnkA-1qlbA:
undetectable		 2nnkA-1qlbA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 ARG A  87
GLU A  66
GLN A 634
 None
 1.08A 2p16A-1qlbA:
undetectable		 2p16A-1qlbA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		3 / 3 LEU B 222
PRO B 223
ARG B 181
 SF4  B1242 ( 4.5A)
None
None
 0.57A 2qd4B-1qlbB:
undetectable		 2qd4B-1qlbB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes;
Wolinella
succinogenes) 		3 / 3 PRO B  49
ASN A 508
ARG A 510
 None
 1.06A 2qeuB-1qlbB:
undetectable		 2qeuB-1qlbB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 5 VAL A 208
TYR A 192
VAL A 433
ASP A 434
 None
 1.16A 2x45A-1qlbA:
0.0		 2x45A-1qlbA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 5 ALA A 209
GLY A 387
CYH A 191
LYS A 190
 None
 1.30A 2yldA-1qlbA:
2.5		 2yldA-1qlbA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 5 ALA A 209
GLY A 387
CYH A 191
LYS A 190
 None
 1.42A 2ylgA-1qlbA:
2.5		 2ylgA-1qlbA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		5 / 11 MET B  34
ILE B  38
ASN B  70
ILE B  28
THR B  46
 None
 1.38A 3a50B-1qlbB:
undetectable		 3a50B-1qlbB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 8 GLY A 236
GLU A 242
ILE A 375
ALA A 394
 FAD  A1656 ( 4.5A)
None
None
None
 0.84A 3aodA-1qlbA:
undetectable		 3aodA-1qlbA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 7 GLY A 421
GLY A 417
GLU A 426
ALA A  23
 None
 0.87A 3fpjB-1qlbA:
undetectable		 3fpjB-1qlbA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		4 / 8 LEU A 268
THR A 269
ALA A  47
ILE B  61
 None
FUM  A1657 (-4.5A)
FAD  A1656 (-3.6A)
None
 0.81A 3jusB-1qlbA:
undetectable		 3jusB-1qlbA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 ARG A 139
VAL A 105
THR A 159
 None
 0.80A 3k4vA-1qlbA:
undetectable		 3k4vA-1qlbA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 ARG A 139
VAL A 105
THR A 159
 None
 0.84A 3k4vD-1qlbA:
0.0		 3k4vD-1qlbA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 8 ASN A 228
THR A 227
LEU A 267
ALA A  46
 FAD  A1656 (-4.4A)
FAD  A1656 (-4.6A)
FAD  A1656 (-4.3A)
FAD  A1656 ( 3.8A)
 0.75A 3kp6A-1qlbA:
undetectable		 3kp6A-1qlbA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		4 / 7 TYR B  26
ASN B  52
LEU B  51
ASP B  50
 None
 1.20A 3lslA-1qlbB:
undetectable
3lslD-1qlbB:
undetectable		 3lslA-1qlbB:
23.21
3lslD-1qlbB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		4 / 6 TYR B  26
ASN B  52
LEU B  51
ASP B  50
 None
 1.06A 3lslG-1qlbB:
undetectable		 3lslG-1qlbB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		6 / 12 ALA A  21
THR A  24
ALA A  23
ALA A  20
VAL A  33
GLY A 172
 None
 1.37A 3mg0Y-1qlbA:
0.0
3mg0Z-1qlbA:
0.0		 3mg0Y-1qlbA:
15.90
3mg0Z-1qlbA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 8 PHE A 424
VAL A 420
GLY A 381
ILE A 375
 None
 0.77A 3n9jB-1qlbA:
undetectable		 3n9jB-1qlbA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 ARG A 139
VAL A 105
THR A 159
 None
 0.81A 3nduD-1qlbA:
undetectable		 3nduD-1qlbA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 9 LEU A 385
THR A 237
LEU A 578
GLU A 579
GLY A 244
 None
 1.24A 3nxuB-1qlbA:
undetectable		 3nxuB-1qlbA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 8 TYR A 223
CYH A 232
GLN A 368
TYR A 219
 None
FAD  A1656 ( 4.6A)
None
None
 1.03A 3po7A-1qlbA:
7.4		 3po7A-1qlbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 ARG A 139
VAL A 105
THR A 159
 None
 0.81A 3pwrA-1qlbA:
undetectable		 3pwrA-1qlbA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 11 VAL A 195
ALA A 194
GLY A 193
TYR A 192
ALA A 246
 None
 1.33A 3qxyB-1qlbA:
undetectable
3qxyQ-1qlbA:
undetectable		 3qxyB-1qlbA:
23.19
3qxyQ-1qlbA:
2.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		4 / 5 SER A  61
GLY A 134
GLU B 140
GLU B 138
 None
 1.27A 3raeB-1qlbA:
0.0
3raeD-1qlbA:
undetectable		 3raeB-1qlbA:
24.67
3raeD-1qlbA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 8 ASP A  82
ASP A 398
GLY A 401
ARG A 540
 None
 0.96A 3s3nA-1qlbA:
undetectable		 3s3nA-1qlbA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 11 TYR A 423
GLY A 421
GLY A  17
ALA A 395
ALA A 394
 None
 1.18A 3sufC-1qlbA:
undetectable		 3sufC-1qlbA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 ARG A 139
VAL A 105
THR A 159
 None
 0.81A 3tl9A-1qlbA:
undetectable		 3tl9A-1qlbA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes;
Wolinella
succinogenes) 		5 / 12 TYR A 521
ILE A 182
VAL A 230
PHE B  53
VAL B  56
 None
None
None
None
FES  B1240 (-4.8A)
 0.97A 3w68B-1qlbA:
undetectable		 3w68B-1qlbA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		5 / 12 ASP B 149
ALA A 163
ILE B 137
ASP B 185
ARG B 181
 None
 1.47A 3weoA-1qlbB:
undetectable		 3weoA-1qlbB:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 5 ALA A 209
GLY A 387
CYH A 191
LYS A 190
 None
 1.31A 3zwiA-1qlbA:
2.5		 3zwiA-1qlbA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 10 SER A 390
ALA A 394
ILE A 375
LEU A 184
ILE A 239
 None
 1.06A 4dt8B-1qlbA:
undetectable		 4dt8B-1qlbA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		3 / 3 PHE B  37
VAL B   9
ILE B   7
 None
 0.37A 4emaA-1qlbB:
undetectable		 4emaA-1qlbB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 8 GLY A 234
THR A 237
MET A 372
GLY A 373
 None
None
None
CA  A1658 (-4.0A)
 0.84A 4fo4B-1qlbA:
undetectable		 4fo4B-1qlbA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 ASP A 302
ARG A 306
ASP A  78
 None
 0.83A 4fzvA-1qlbA:
undetectable		 4fzvA-1qlbA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 6 ASP A 557
ARG A 555
GLY A  80
VAL A  74
 None
 1.06A 4oltA-1qlbA:
undetectable		 4oltA-1qlbA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 6 ASP A 557
ARG A 555
GLY A  80
VAL A  74
 None
 1.04A 4oltB-1qlbA:
undetectable		 4oltB-1qlbA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 LEU A 326
LEU A 267
ASN A 225
 None
FAD  A1656 (-4.3A)
None
 0.75A 4otwA-1qlbA:
undetectable		 4otwA-1qlbA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 PRO A 524
MET A 525
TYR A 521
 None
 0.95A 4qa2B-1qlbA:
undetectable		 4qa2B-1qlbA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 11 SER A 390
THR A 237
THR A 235
GLY A 218
ALA A 394
 None
None
FAD  A1656 (-3.8A)
None
None
 1.49A 4qvpH-1qlbA:
undetectable
4qvpN-1qlbA:
undetectable		 4qvpH-1qlbA:
18.48
4qvpN-1qlbA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 11 SER A 390
THR A 237
THR A 235
GLY A 218
ALA A 394
 None
None
FAD  A1656 (-3.8A)
None
None
 1.49A 4qw1V-1qlbA:
undetectable
4qw1b-1qlbA:
undetectable		 4qw1V-1qlbA:
18.48
4qw1b-1qlbA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 11 SER A 390
THR A 237
THR A 235
GLY A 218
ALA A 394
 None
None
FAD  A1656 (-3.8A)
None
None
 1.48A 4qw1H-1qlbA:
undetectable
4qw1N-1qlbA:
undetectable		 4qw1H-1qlbA:
18.48
4qw1N-1qlbA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 11 SER A 390
THR A 237
THR A 235
GLY A 218
ALA A 394
 None
None
FAD  A1656 (-3.8A)
None
None
 1.50A 4qwuV-1qlbA:
undetectable
4qwub-1qlbA:
undetectable		 4qwuV-1qlbA:
18.48
4qwub-1qlbA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 11 SER A 390
THR A 237
THR A 235
GLY A 218
ALA A 394
 None
None
FAD  A1656 (-3.8A)
None
None
 1.50A 4qwuH-1qlbA:
undetectable
4qwuN-1qlbA:
undetectable		 4qwuH-1qlbA:
18.48
4qwuN-1qlbA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		4 / 6 ARG B   3
GLY B   2
THR B  81
GLU B  30
 None
 1.07A 5btaA-1qlbB:
undetectable
5btaB-1qlbB:
undetectable
5btaC-1qlbB:
undetectable		 5btaA-1qlbB:
20.04
5btaB-1qlbB:
22.26
5btaC-1qlbB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		4 / 6 ARG B   3
GLY B   2
THR B  81
GLU B  30
 None
 1.06A 5btcA-1qlbB:
undetectable
5btcC-1qlbB:
undetectable
5btcD-1qlbB:
undetectable		 5btcA-1qlbB:
20.04
5btcC-1qlbB:
20.04
5btcD-1qlbB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		4 / 6 ARG B   3
GLY B   2
THR B  81
GLU B  30
 None
 1.06A 5btcA-1qlbB:
undetectable
5btcB-1qlbB:
undetectable
5btcC-1qlbB:
undetectable		 5btcA-1qlbB:
20.04
5btcB-1qlbB:
22.26
5btcC-1qlbB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		4 / 7 ARG B   3
GLY B   2
THR B  81
GLU B  30
 None
 1.13A 5btfA-1qlbB:
0.0
5btfC-1qlbB:
undetectable
5btfD-1qlbB:
undetectable		 5btfA-1qlbB:
20.04
5btfC-1qlbB:
20.04
5btfD-1qlbB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		4 / 5 LEU B  80
PHE B  84
ILE B  36
ILE B  69
 None
 0.95A 5dzk4-1qlbB:
undetectable
5dzkg-1qlbB:
undetectable
5dzkm-1qlbB:
undetectable
5dzkn-1qlbB:
undetectable		 5dzk4-1qlbB:
2.17
5dzkg-1qlbB:
24.16
5dzkm-1qlbB:
18.25
5dzkn-1qlbB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 7 ALA A  47
GLU A 393
SER A 409
ARG A 404
GLY A 407
 FAD  A1656 (-3.6A)
FAD  A1656 ( 3.6A)
FAD  A1656 (-2.7A)
FUM  A1657 ( 2.7A)
FAD  A1656 ( 3.0A)
 1.27A 5e26A-1qlbA:
undetectable
5e26B-1qlbA:
undetectable		 5e26A-1qlbA:
19.64
5e26B-1qlbA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		4 / 7 ALA B  76
GLY B  66
SER B  64
GLY B  63
 None
None
FES  B1240 ( 4.9A)
FES  B1240 (-4.0A)
 0.88A 5e26A-1qlbB:
undetectable
5e26B-1qlbB:
undetectable		 5e26A-1qlbB:
22.95
5e26B-1qlbB:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 4 THR A 144
LEU A 405
HIS A  69
GLY A 407
 None
None
None
FAD  A1656 ( 3.0A)
 0.99A 5gwyA-1qlbA:
0.0		 5gwyA-1qlbA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 12 ILE A  11
GLY A 236
THR A 235
ALA A 181
LEU A  34
 None
FAD  A1656 ( 4.5A)
FAD  A1656 (-3.8A)
FAD  A1656 (-3.8A)
None
 1.17A 5hw4A-1qlbA:
0.0		 5hw4A-1qlbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 12 ILE A  11
GLY A 236
THR A 235
ALA A 181
LEU A  34
 None
FAD  A1656 ( 4.5A)
FAD  A1656 (-3.8A)
FAD  A1656 (-3.8A)
None
 1.16A 5hw4C-1qlbA:
0.0		 5hw4C-1qlbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes;
Wolinella
succinogenes) 		5 / 12 ILE A 419
GLY A 421
GLU A  66
ALA A 413
ILE B 130
 None
None
None
FAD  A1656 ( 3.8A)
None
 1.18A 5igyA-1qlbA:
undetectable		 5igyA-1qlbA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes;
Wolinella
succinogenes) 		4 / 5 ARG B 136
LEU A 135
LEU A 653
PHE A 131
 None
 1.20A 5iy5P-1qlbB:
undetectable
5iy5W-1qlbB:
undetectable		 5iy5P-1qlbB:
21.31
5iy5W-1qlbB:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 5 ALA A 209
GLY A 387
CYH A 191
LYS A 190
 None
 1.37A 5jliA-1qlbA:
2.5		 5jliA-1qlbA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 5 ALA A 209
GLY A 387
CYH A 191
LYS A 190
 None
 1.34A 5jt4A-1qlbA:
2.5		 5jt4A-1qlbA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 LYS A 360
ASP A 356
ILE A 278
 None
 0.68A 5kc4E-1qlbA:
2.1		 5kc4E-1qlbA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 6 VAL A 410
ARG A 404
GLN A  52
HIS A 400
 FAD  A1656 (-3.7A)
FUM  A1657 ( 2.7A)
None
None
 1.44A 5kkzA-1qlbA:
0.0
5kkzG-1qlbA:
0.0		 5kkzA-1qlbA:
21.67
5kkzG-1qlbA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 5 GLU A 393
SER A 409
ARG A 404
GLY A 407
 FAD  A1656 ( 3.6A)
FAD  A1656 (-2.7A)
FUM  A1657 ( 2.7A)
FAD  A1656 ( 3.0A)
 0.92A 5kprA-1qlbA:
undetectable		 5kprA-1qlbA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		4 / 7 ILE B   7
LEU B  91
MET B  67
LEU B 103
 None
 1.01A 5u4sA-1qlbB:
undetectable		 5u4sA-1qlbB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 12 ILE A 136
ASP A  64
LEU A 100
VAL A 105
GLY A 142
 None
 0.96A 5uxdB-1qlbA:
0.0		 5uxdB-1qlbA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 12 ILE A 375
ALA A 246
THR A 243
ALA A 183
GLU A 180
 None
 1.06A 5vceA-1qlbA:
undetectable		 5vceA-1qlbA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes;
Wolinella
succinogenes) 		4 / 5 ARG B 136
LEU A 135
LEU A 653
PHE A 131
 None
 1.05A 5x1fC-1qlbB:
1.1
5x1fJ-1qlbB:
0.0		 5x1fC-1qlbB:
21.43
5x1fJ-1qlbB:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes;
Wolinella
succinogenes) 		4 / 5 ARG B 136
LEU A 135
LEU A 653
PHE A 131
 None
 1.19A 5xdxC-1qlbB:
undetectable
5xdxJ-1qlbB:
undetectable		 5xdxC-1qlbB:
20.89
5xdxJ-1qlbB:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes;
Wolinella
succinogenes) 		4 / 5 ARG B 136
LEU A 135
LEU A 653
PHE A 131
 None
 1.23A 5xdxP-1qlbB:
undetectable
5xdxW-1qlbB:
undetectable		 5xdxP-1qlbB:
20.89
5xdxW-1qlbB:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 8 GLY A 134
LEU A 135
ASN A  57
SER A  58
 None
 0.87A 5xu8A-1qlbA:
undetectable		 5xu8A-1qlbA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 TYR A 151
ALA A  53
LEU A  55
 None
 0.49A 6ag0C-1qlbA:
undetectable		 6ag0C-1qlbA:
8.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 HIS A 257
HIS A 369
ARG A 404
 FUM  A1657 (-4.0A)
FUM  A1657 ( 3.7A)
FUM  A1657 ( 2.7A)
 0.37A 6b58A-1qlbA:
44.1		 6b58A-1qlbA:
35.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		3 / 3 ILE B 152
ASN B 177
CYH B 214
 SF4  B1242 (-4.7A)
None
F3S  B1241 (-2.1A)
 0.84A 6bp4A-1qlbB:
undetectable		 6bp4A-1qlbB:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 ARG A 301
HIS A 369
ARG A 404
 FUM  A1657 (-2.6A)
FUM  A1657 ( 3.7A)
FUM  A1657 ( 2.7A)
 0.89A 6dwdD-1qlbA:
0.0		 6dwdD-1qlbA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		4 / 6 PHE B  97
LEU B  94
ALA B 159
SER B  74
 None
 0.91A 6f88A-1qlbB:
undetectable		 6f88A-1qlbB:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		4 / 6 ASP B  48
ASP B  50
GLN B  24
LYS B 101
 None
 1.41A 6g31L-1qlbB:
undetectable		 6g31L-1qlbB:
17.32