SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qlm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		5 / 11 LEU A 310
GLY A 233
GLY A 234
LEU A  75
HIS A  70
 None
 1.08A 1mx1A-1qlmA:
undetectable		 1mx1A-1qlmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		4 / 6 PRO A 170
ALA A  42
GLU A  25
GLU A  41
 None
 1.37A 1qhyA-1qlmA:
undetectable		 1qhyA-1qlmA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		5 / 12 ILE A 268
ALA A 257
GLY A 282
VAL A 195
PRO A 254
 None
 1.04A 2okcA-1qlmA:
undetectable		 2okcA-1qlmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		5 / 12 ILE A 268
ALA A 257
GLY A 282
VAL A 195
PRO A 254
 None
 1.04A 2okcB-1qlmA:
undetectable		 2okcB-1qlmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		4 / 5 ARG A 225
ALA A 216
ASP A 217
GLU A 221
 None
 1.50A 2xrzA-1qlmA:
undetectable		 2xrzA-1qlmA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		5 / 12 GLY A 208
ILE A 230
GLY A 233
ILE A 305
PRO A 254
 None
 1.02A 3d1zA-1qlmA:
undetectable		 3d1zA-1qlmA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		4 / 5 ALA A 287
LEU A 253
GLY A 188
THR A  82
 None
 0.86A 3dl9A-1qlmA:
undetectable		 3dl9A-1qlmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		4 / 5 PRO A 111
SER A 109
LEU A  60
SER A  88
 None
 1.29A 3ijxH-1qlmA:
undetectable		 3ijxH-1qlmA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		4 / 5 PRO A 111
SER A 109
LEU A  60
SER A  88
 None
 1.39A 3iluH-1qlmA:
undetectable		 3iluH-1qlmA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		5 / 12 GLY A 224
THR A 226
PHE A 269
ILE A 268
ARG A 183
 None
None
None
None
PO4  A 400 (-3.4A)
 1.26A 3iv6D-1qlmA:
undetectable		 3iv6D-1qlmA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		5 / 12 VAL A 159
ASP A 160
LEU A 167
GLY A  32
LEU A  29
 None
 1.25A 3j6pB-1qlmA:
undetectable		 3j6pB-1qlmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		5 / 12 LEU A 310
PHE A  68
ILE A 305
GLY A 234
ALA A 287
 None
 1.06A 3kk6A-1qlmA:
undetectable		 3kk6A-1qlmA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		4 / 6 LEU A 189
TYR A 190
ALA A 285
LEU A  90
 None
 0.87A 3ravA-1qlmA:
undetectable		 3ravA-1qlmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		4 / 6 LEU A 189
TYR A 190
ALA A 285
LEU A  90
 None
 0.88A 3rd0A-1qlmA:
undetectable		 3rd0A-1qlmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		5 / 12 ASP A  71
THR A 235
THR A 209
ALA A 210
ALA A  77
 None
 1.34A 4u15A-1qlmA:
undetectable		 4u15A-1qlmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		5 / 12 ASP A  71
THR A 235
THR A 209
ALA A 210
ALA A  77
 None
 1.33A 4u15B-1qlmA:
undetectable		 4u15B-1qlmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		4 / 9 CYH A  56
SER A 109
LEU A 166
ILE A 136
 None
 0.97A 4xtaA-1qlmA:
undetectable		 4xtaA-1qlmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		4 / 8 CYH A  56
SER A 109
LEU A 166
ILE A 136
 None
 0.93A 4xtaB-1qlmA:
undetectable		 4xtaB-1qlmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		4 / 7 VAL A  99
LEU A 139
SER A 141
GLU A 143
 None
 0.99A 4zphA-1qlmA:
0.0
4zphB-1qlmA:
undetectable		 4zphA-1qlmA:
20.78
4zphB-1qlmA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		5 / 12 PRO A  10
MET A  15
ILE A  36
LEU A  11
THR A  33
 None
 1.21A 5tiwB-1qlmA:
undetectable		 5tiwB-1qlmA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanopyrus
kandleri) 		3 / 3 HIS A  70
ARG A 288
ILE A 305
 None
 0.74A 6fgdA-1qlmA:
undetectable		 6fgdA-1qlmA:
22.15