SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qmh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		4 / 8 THR A 312
GLY A  10
ALA A  23
ILE A  36
 None
 0.81A 1c9sI-1qmhA:
undetectable
1c9sJ-1qmhA:
undetectable		 1c9sI-1qmhA:
15.23
1c9sJ-1qmhA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		4 / 7 GLY A  10
ALA A  23
ILE A  36
THR A 312
 None
 0.83A 1gtnA-1qmhA:
undetectable
1gtnK-1qmhA:
undetectable		 1gtnA-1qmhA:
15.23
1gtnK-1qmhA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		4 / 8 THR A 312
GLY A  10
ALA A  23
ILE A  36
 None
 0.81A 1gtnA-1qmhA:
undetectable
1gtnB-1qmhA:
undetectable		 1gtnA-1qmhA:
15.23
1gtnB-1qmhA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		4 / 8 THR A 312
GLY A  10
ALA A  23
ILE A  36
 None
 0.81A 1gtnE-1qmhA:
undetectable
1gtnF-1qmhA:
undetectable		 1gtnE-1qmhA:
15.23
1gtnF-1qmhA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		4 / 8 GLY A  10
ALA A  23
ILE A  36
THR A 312
 None
 0.82A 1utdF-1qmhA:
undetectable
1utdG-1qmhA:
undetectable		 1utdF-1qmhA:
15.23
1utdG-1qmhA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		4 / 8 GLY A  10
ALA A  23
ILE A  36
THR A 312
 None
 0.80A 1utdJ-1qmhA:
undetectable
1utdK-1qmhA:
undetectable		 1utdJ-1qmhA:
15.23
1utdK-1qmhA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		5 / 12 LEU A 155
GLY A 123
GLY A 166
ILE A 136
VAL A 121
 None
 1.04A 1v2xA-1qmhA:
2.3		 1v2xA-1qmhA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		3 / 3 HIS A  52
PHE A  79
PHE A  34
 CIT  A 401 (-3.8A)
None
None
 0.75A 3lk0D-1qmhA:
undetectable		 3lk0D-1qmhA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		4 / 7 TYR A 274
MET A 192
LEU A 219
LEU A 275
 None
 1.20A 3nk2X-1qmhA:
undetectable		 3nk2X-1qmhA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		4 / 4 LEU A  48
GLY A  73
LEU A  72
GLU A  71
 None
 0.95A 3tgvB-1qmhA:
undetectable		 3tgvB-1qmhA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQE_B_DXCB1079_0
(PROTEIN PRGI, CELL
INVASION PROTEIN
SIPD)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		5 / 11 GLN A 104
THR A 105
LEU A  24
ARG A  40
GLN A  18
 None
None
None
CIT  A 401 (-3.6A)
None
 1.42A 3zqeA-1qmhA:
undetectable
3zqeB-1qmhA:
0.0		 3zqeA-1qmhA:
22.84
3zqeB-1qmhA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		6 / 9 ALA A  59
LEU A  24
ALA A  55
LEU A  20
LEU A  77
ALA A  70
 None
 1.21A 4z91F-1qmhA:
0.0
4z91G-1qmhA:
0.0
4z91H-1qmhA:
0.0
4z91I-1qmhA:
0.0
4z91J-1qmhA:
0.0		 4z91F-1qmhA:
21.28
4z91G-1qmhA:
21.28
4z91H-1qmhA:
21.28
4z91I-1qmhA:
21.28
4z91J-1qmhA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		6 / 9 LEU A  24
ALA A  55
LEU A  20
LEU A  77
ALA A  70
ALA A  59
 None
 1.17A 4z91F-1qmhA:
0.0
4z91G-1qmhA:
0.0
4z91H-1qmhA:
0.0
4z91I-1qmhA:
0.0
4z91J-1qmhA:
0.0		 4z91F-1qmhA:
21.28
4z91G-1qmhA:
21.28
4z91H-1qmhA:
21.28
4z91I-1qmhA:
21.28
4z91J-1qmhA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		3 / 3 ASP A 126
ASN A 235
PHE A 135
 None
 0.81A 5jglB-1qmhA:
undetectable		 5jglB-1qmhA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		4 / 4 GLN A 104
THR A 105
LEU A 295
LEU A 291
 None
 1.22A 5m5kB-1qmhA:
undetectable		 5m5kB-1qmhA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		4 / 8 HIS A 158
ASP A 126
SER A  98
ASP A 134
 None
 1.23A 5t8sB-1qmhA:
undetectable		 5t8sB-1qmhA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		5 / 10 LEU A 227
GLY A 200
VAL A 205
ASN A 226
HIS A 225
 None
 1.24A 5tqrB-1qmhA:
0.0		 5tqrB-1qmhA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		4 / 6 VAL A 121
LEU A 197
ARG A 249
PRO A 132
 None
 1.28A 6brdB-1qmhA:
undetectable		 6brdB-1qmhA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE
(Escherichia
coli) 		5 / 10 VAL A  67
LEU A  78
LEU A  20
GLY A  64
VAL A  56
 None
 1.12A 6eu9B-1qmhA:
0.0		 6eu9B-1qmhA:
13.68