SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qnh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		4 / 4 SER A  27
ILE A  29
VAL A 134
THR A 122
 None
 1.18A 1u70A-1qnhA:
undetectable		 1u70A-1qnhA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		4 / 6 PHE A  23
PHE A  37
GLY A  71
GLY A  72
 None
 0.86A 2qr2A-1qnhA:
undetectable
2qr2B-1qnhA:
undetectable		 2qr2A-1qnhA:
21.76
2qr2B-1qnhA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		4 / 5 GLY A  71
GLY A  72
PHE A  23
PHE A  37
 None
 0.80A 2qr2A-1qnhA:
undetectable
2qr2B-1qnhA:
undetectable		 2qr2A-1qnhA:
21.76
2qr2B-1qnhA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		4 / 6 PHE A  23
PHE A  37
GLY A  71
GLY A  72
 None
 0.77A 2qx6A-1qnhA:
undetectable
2qx6B-1qnhA:
undetectable		 2qx6A-1qnhA:
21.76
2qx6B-1qnhA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		4 / 8 LEU A 105
ILE A 165
PHE A  60
MET A 149
 None
 0.96A 2weyB-1qnhA:
undetectable		 2weyB-1qnhA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		5 / 11 ILE A  74
GLY A  72
PHE A 119
PHE A   9
ILE A 165
 None
 1.29A 2y7kA-1qnhA:
undetectable		 2y7kA-1qnhA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		5 / 10 ILE A  74
GLY A  72
PHE A 119
PHE A   9
ILE A 165
 None
 1.33A 2y7kB-1qnhA:
undetectable		 2y7kB-1qnhA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		5 / 12 ILE A  74
GLY A  72
PHE A 119
PHE A   9
ILE A 165
 None
 1.22A 2y7kC-1qnhA:
undetectable		 2y7kC-1qnhA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		5 / 12 ILE A  74
GLY A  72
PHE A 119
PHE A   9
ILE A 165
 None
 1.22A 2y7kD-1qnhA:
undetectable		 2y7kD-1qnhA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		5 / 7 ILE A  74
GLY A  72
PHE A 119
PHE A   9
ILE A 165
 None
 1.16A 2y7wC-1qnhA:
undetectable		 2y7wC-1qnhA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		5 / 10 ILE A  59
VAL A 163
GLY A 157
ILE A  64
VAL A 146
 None
 0.93A 3ogpB-1qnhA:
undetectable		 3ogpB-1qnhA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		5 / 11 PHE A  23
PHE A  37
GLY A  71
GLY A  72
ILE A  59
 None
 1.01A 3owxA-1qnhA:
undetectable
3owxB-1qnhA:
undetectable		 3owxA-1qnhA:
21.67
3owxB-1qnhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		4 / 6 TYR A  55
HIS A  54
VAL A 164
PHE A 119
 None
 1.20A 4a97E-1qnhA:
undetectable		 4a97E-1qnhA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		4 / 4 ASN A  17
VAL A 145
THR A 166
ILE A 165
 None
 1.05A 4retA-1qnhA:
undetectable		 4retA-1qnhA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		4 / 4 ASN A  17
VAL A 145
THR A 166
ILE A 165
 None
 1.05A 4retC-1qnhA:
undetectable		 4retC-1qnhA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		3 / 3 LEU A  25
ASP A  28
ILE A  22
 None
 0.62A 4xi3D-1qnhA:
undetectable		 4xi3D-1qnhA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		4 / 6 ILE A  64
PRO A  65
ILE A  13
VAL A 163
 None
 1.01A 4zj8A-1qnhA:
undetectable		 4zj8A-1qnhA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		5 / 12 GLY A  71
GLY A  72
ILE A  59
PHE A  23
PHE A  37
 None
 0.80A 4zvmA-1qnhA:
undetectable
4zvmB-1qnhA:
undetectable		 4zvmA-1qnhA:
21.76
4zvmB-1qnhA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
falciparum) 		5 / 11 PHE A  23
PHE A  37
GLY A  71
GLY A  72
ILE A  59
 None
 0.91A 4zvmA-1qnhA:
undetectable
4zvmB-1qnhA:
undetectable		 4zvmA-1qnhA:
21.76
4zvmB-1qnhA:
21.76