SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qnl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 PHE A 268
GLY A  30
THR A 281
PHE A 276
 None
 1.39A 1icvA-1qnlA:
0.0
1icvB-1qnlA:
0.0		 1icvA-1qnlA:
19.44
1icvB-1qnlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 TYR A  83
TYR A 104
GLU A  24
TYR A 180
 BMD  A1001 (-3.0A)
None
None
None
 1.06A 1nx9A-1qnlA:
2.1		 1nx9A-1qnlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 TYR A  83
TYR A 104
GLU A  24
TYR A 180
 BMD  A1001 (-3.0A)
None
None
None
 1.07A 1nx9B-1qnlA:
undetectable		 1nx9B-1qnlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 TYR A  83
TYR A 104
GLU A  24
TYR A 180
 BMD  A1001 (-3.0A)
None
None
None
 1.07A 1nx9C-1qnlA:
undetectable		 1nx9C-1qnlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 TYR A  83
TYR A 104
GLU A  24
TYR A 180
 BMD  A1001 (-3.0A)
None
None
None
 1.08A 1nx9D-1qnlA:
undetectable		 1nx9D-1qnlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 THR A  51
LEU A  38
VAL A  35
VAL A  80
 None
 0.94A 1t86A-1qnlA:
undetectable		 1t86A-1qnlA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 GLY A  18
PRO A  56
ASP A  59
THR A  87
 None
 1.04A 2aouB-1qnlA:
undetectable		 2aouB-1qnlA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 THR A  51
LEU A  38
VAL A  35
VAL A  80
 None
 1.00A 2cppA-1qnlA:
0.0		 2cppA-1qnlA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 SER A  26
TRP A 285
ASP A 261
ILE A 260
 None
 1.09A 2oxtD-1qnlA:
1.7		 2oxtD-1qnlA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 145
GLY A 147
VAL A 205
LEU A 213
 None
 0.86A 3bgdB-1qnlA:
2.3		 3bgdB-1qnlA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 295
GLY A 297
VAL A  44
LEU A 101
ILE A  10
 None
 1.31A 3h52A-1qnlA:
undetectable		 3h52A-1qnlA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 119
TYR A 104
ALA A 123
GLY A 121
SER A 336
 None
 1.02A 3ou7A-1qnlA:
undetectable		 3ou7A-1qnlA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 119
TYR A 104
ALA A 123
GLY A 121
SER A 336
 None
 1.03A 3ou7D-1qnlA:
undetectable		 3ou7D-1qnlA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 TYR A 194
VAL A 205
VAL A 201
ILE A 175
 None
 1.06A 3pyyA-1qnlA:
undetectable		 3pyyA-1qnlA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 240
GLY A 349
ILE A 345
THR A 283
 None
 0.84A 3spkB-1qnlA:
undetectable		 3spkB-1qnlA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 SER A 235
PRO A 255
TYR A 256
VAL A 253
 None
 1.25A 3sufC-1qnlA:
undetectable		 3sufC-1qnlA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 175
LEU A 135
ILE A 217
ILE A 229
VAL A 251
 None
 1.06A 3w67B-1qnlA:
undetectable		 3w67B-1qnlA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 TYR A 139
TYR A 134
LEU A 135
TYR A 214
 None
 1.19A 4f8yC-1qnlA:
4.8
4f8yD-1qnlA:
3.1		 4f8yC-1qnlA:
17.65
4f8yD-1qnlA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 THR A  51
LEU A  38
VAL A  35
VAL A  80
 None
 0.95A 4l4aA-1qnlA:
0.0		 4l4aA-1qnlA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 264
SER A 265
GLN A 356
SER A 339
 None
 1.00A 5c6pA-1qnlA:
undetectable		 5c6pA-1qnlA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		5 / 9 ILE A  71
GLY A  11
ASN A 116
LEU A 101
LEU A 296
 None
 1.34A 5fhzB-1qnlA:
3.1		 5fhzB-1qnlA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 HIS A 158
HIS A 162
LEU A 163
VAL A 368
 None
 1.06A 5m8rA-1qnlA:
undetectable		 5m8rA-1qnlA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 158
HIS A 162
LEU A 163
VAL A 368
 None
 0.97A 5m8rD-1qnlA:
undetectable		 5m8rD-1qnlA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 206
GLY A 207
GLU A 238
SER A 235
ASN A 106
 None
None
None
None
BMD  A1001 ( 4.0A)
 1.02A 5x6yA-1qnlA:
2.2		 5x6yA-1qnlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 206
GLY A 207
GLU A 238
SER A 235
ASN A 106
 None
None
None
None
BMD  A1001 ( 4.0A)
 1.18A 5x6yC-1qnlA:
3.2		 5x6yC-1qnlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 322
VAL A 329
GLY A 120
LEU A 101
LEU A 315
 None
 1.01A 5xxiA-1qnlA:
undetectable		 5xxiA-1qnlA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 ILE A  10
GLN A 292
THR A 293
LEU A  13
 None
 1.04A 6f3mD-1qnlA:
2.1		 6f3mD-1qnlA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 177
ILE A 175
VAL A 205
THR A 204
ILE A 146
 None
 1.00A 6hlpA-1qnlA:
5.7		 6hlpA-1qnlA:
19.22