SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qo8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		3 / 3 ALA A 132
VAL A 549
TRP A 217
 FAD  A 605 (-3.3A)
None
None
 1.00A 1c4dA-1qo8A:
undetectable
1c4dB-1qo8A:
undetectable		 1c4dA-1qo8A:
2.95
1c4dB-1qo8A:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		3 / 3 TRP A 217
ALA A 132
VAL A 549
 None
FAD  A 605 (-3.3A)
None
 0.94A 1c4dA-1qo8A:
undetectable
1c4dB-1qo8A:
undetectable		 1c4dA-1qo8A:
2.95
1c4dB-1qo8A:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		3 / 3 ALA A 132
VAL A 549
TRP A 217
 FAD  A 605 (-3.3A)
None
None
 0.87A 1c4dC-1qo8A:
undetectable
1c4dD-1qo8A:
undetectable		 1c4dC-1qo8A:
2.95
1c4dD-1qo8A:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		3 / 3 TRP A 217
ALA A 132
VAL A 549
 None
FAD  A 605 (-3.3A)
None
 0.75A 1c4dC-1qo8A:
undetectable
1c4dD-1qo8A:
undetectable		 1c4dC-1qo8A:
2.95
1c4dD-1qo8A:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		4 / 8 ALA A 129
LEU A 149
LEU A 125
LEU A 269
 None
 0.92A 1ereE-1qo8A:
undetectable		 1ereE-1qo8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		4 / 8 ALA A 129
LEU A 149
LEU A 125
LEU A 269
 None
 0.92A 1ereF-1qo8A:
undetectable		 1ereF-1qo8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		5 / 12 GLY A 532
GLY A 533
HIS A 535
GLY A 309
ASN A 314
 None
None
None
FAD  A 605 (-3.3A)
None
 0.78A 1n2xB-1qo8A:
undetectable		 1n2xB-1qo8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		3 / 3 ALA A 132
VAL A 549
TRP A 217
 FAD  A 605 (-3.3A)
None
None
 0.94A 1tkqB-1qo8A:
undetectable		 1tkqB-1qo8A:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		4 / 9 ILE A 371
ARG A 376
ALA A 412
VAL A 494
 None
 0.96A 2vufB-1qo8A:
undetectable		 2vufB-1qo8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		4 / 7 TRP A 186
GLY A 179
ASP A 182
ARG A 238
 None
 1.34A 3arrA-1qo8A:
undetectable		 3arrA-1qo8A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		5 / 6 GLY A 504
GLY A 532
GLY A 533
GLY A 503
GLY A 536
 None
 1.13A 3bogA-1qo8A:
0.0
3bogC-1qo8A:
0.0		 3bogA-1qo8A:
undetectable
3bogC-1qo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		3 / 3 GLY A 128
ASP A 151
SER A 156
 FAD  A 605 (-3.0A)
FAD  A 605 (-2.8A)
None
 0.69A 3brfA-1qo8A:
undetectable		 3brfA-1qo8A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		5 / 12 ILE A 253
GLY A 157
GLY A 158
ALA A 153
ALA A 132
 None
FAD  A 605 (-4.5A)
FAD  A 605 (-3.3A)
FAD  A 605 ( 3.8A)
FAD  A 605 (-3.3A)
 0.99A 3jb2A-1qo8A:
2.0		 3jb2A-1qo8A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		3 / 3 PHE A  85
CYH A  79
HIS A  83
 HEM  A 601 (-4.7A)
HEM  A 601 (-2.3A)
HEM  A 601 (-3.1A)
 1.06A 3u9fF-1qo8A:
undetectable		 3u9fF-1qo8A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		3 / 3 PHE A  85
CYH A  79
HIS A  83
 HEM  A 601 (-4.7A)
HEM  A 601 (-2.3A)
HEM  A 601 (-3.1A)
 1.15A 3u9fG-1qo8A:
undetectable		 3u9fG-1qo8A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		3 / 3 PHE A  85
CYH A  79
HIS A  83
 HEM  A 601 (-4.7A)
HEM  A 601 (-2.3A)
HEM  A 601 (-3.1A)
 1.16A 3u9fL-1qo8A:
0.0		 3u9fL-1qo8A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		3 / 3 PHE A  85
CYH A  79
HIS A  83
 HEM  A 601 (-4.7A)
HEM  A 601 (-2.3A)
HEM  A 601 (-3.1A)
 1.13A 3u9fS-1qo8A:
undetectable		 3u9fS-1qo8A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		3 / 3 ARG A 477
MET A 382
ARG A 389
 None
 1.20A 3uvvA-1qo8A:
0.0		 3uvvA-1qo8A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		4 / 4 ASN A 332
ALA A 336
GLY A 312
THR A 501
 FAD  A 605 (-4.2A)
None
None
None
 1.27A 4bboC-1qo8A:
undetectable		 4bboC-1qo8A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		5 / 10 ILE A 299
LEU A 125
ASP A  27
GLY A 291
SER A 271
 None
 1.19A 4bwlC-1qo8A:
undetectable		 4bwlC-1qo8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		5 / 8 VAL A 378
LEU A 420
ILE A 415
VAL A 494
THR A 362
 None
 1.49A 4ma7A-1qo8A:
undetectable		 4ma7A-1qo8A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		5 / 8 LYS A 258
ALA A 259
GLY A 222
LEU A 221
LEU A 138
 None
 1.38A 4po0A-1qo8A:
2.6		 4po0A-1qo8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		5 / 12 VAL A 150
GLY A 286
GLY A 300
LEU A 276
VAL A 304
 None
 1.01A 4qdjA-1qo8A:
undetectable		 4qdjA-1qo8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		4 / 4 GLY A 166
LEU A 256
PHE A 134
ILE A 253
 FAD  A 605 (-4.3A)
None
None
None
 0.91A 4xv2A-1qo8A:
undetectable		 4xv2A-1qo8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		5 / 12 THR A 255
LEU A 256
GLY A 158
SER A 156
ALA A 129
 None
None
FAD  A 605 (-3.3A)
None
None
 1.20A 4ypmA-1qo8A:
undetectable		 4ypmA-1qo8A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		3 / 3 ASP A  27
GLU A  32
SER A 119
 None
 0.79A 5bw4B-1qo8A:
2.3		 5bw4B-1qo8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		4 / 7 GLY A 166
ARG A 539
GLY A 541
ALA A 164
 FAD  A 605 (-4.3A)
FAD  A 605 (-4.3A)
FAD  A 605 ( 4.8A)
FAD  A 605 (-3.5A)
 0.97A 5e26A-1qo8A:
undetectable
5e26B-1qo8A:
undetectable		 5e26A-1qo8A:
21.05
5e26B-1qo8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		4 / 6 PHE A 525
SER A 303
VAL A 124
ASP A 557
 None
 1.25A 5hesA-1qo8A:
undetectable		 5hesA-1qo8A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		4 / 5 CYH A  68
ILE A  63
HIS A  56
TYR A  43
 HEM  A 602 (-2.4A)
None
HEM  A 602 (-3.4A)
HEM  A 602 (-3.7A)
 1.47A 5ocsC-1qo8A:
undetectable		 5ocsC-1qo8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		3 / 3 LEU A 138
ALA A 139
LEU A 221
 None
 0.48A 5uunB-1qo8A:
undetectable		 5uunB-1qo8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		5 / 12 VAL A 284
LEU A 306
LEU A 125
ILE A 299
ALA A 301
 None
 1.15A 5xprA-1qo8A:
0.2		 5xprA-1qo8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE
(Shewanella
frigidimarina) 		3 / 3 HIS A 360
HIS A 499
ARG A 539
 None
FAD  A 605 (-4.1A)
FAD  A 605 (-4.3A)
 0.73A 6b58A-1qo8A:
32.8		 6b58A-1qo8A:
22.44