SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qon'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ACJ_A_THAA999_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 9 TRP A  83
GLY A 149
TRP A 472
HIS A 480
GLY A 481
 I40  A 997 (-3.2A)
SO4  A 593 ( 4.2A)
I40  A 997 (-4.0A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 0.93A 1acjA-1qonA:
60.0		 1acjA-1qonA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ACJ_A_THAA999_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 9 TRP A  83
GLY A 150
GLU A 237
TYR A 374
TRP A 472
HIS A 480
GLY A 481
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
I40  A 997 ( 3.9A)
I40  A 997 (-4.0A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 0.32A 1acjA-1qonA:
60.0		 1acjA-1qonA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ACL_A_DMEA999_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 10 TRP A  83
GLU A 237
SER A 238
TRP A 321
TYR A 374
HIS A 480
GLY A 481
 I40  A 997 (-3.2A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
None
I40  A 997 ( 3.9A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 0.66A 1aclA-1qonA:
59.9		 1aclA-1qonA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ACL_A_DMEA999_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 10 TYR A  73
TRP A  83
GLU A 237
HIS A 480
GLY A 481
 None
I40  A 997 (-3.2A)
I40  A 997 (-4.2A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 1.47A 1aclA-1qonA:
59.9		 1aclA-1qonA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 8 GLY A 151
GLU A 237
PHE A 371
HIS A 480
 SO4  A 593 (-3.4A)
I40  A 997 (-4.2A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.96A 1ax9A-1qonA:
55.7		 1ax9A-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 8 TRP A  83
GLY A 149
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
SO4  A 593 ( 4.2A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.01A 1ax9A-1qonA:
55.7		 1ax9A-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 8 TRP A  83
GLY A 150
GLU A 237
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.39A 1ax9A-1qonA:
55.7		 1ax9A-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 8 TRP A  83
GLY A 150
GLU A 237
SER A 238
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
SO4  A 593 (-4.1A)
 0.57A 1ax9A-1qonA:
55.7		 1ax9A-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 12 GLY A 240
GLY A 151
SER A 238
TRP A 271
PHE A 330
PHE A 371
HIS A 480
 None
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
SO4  A 593 (-4.4A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.23A 1dx6A-1qonA:
60.5		 1dx6A-1qonA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		9 / 12 TRP A  83
GLY A 149
GLY A 150
GLY A 151
SER A 238
TRP A 271
PHE A 330
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
SO4  A 593 (-4.4A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.54A 1dx6A-1qonA:
60.5		 1dx6A-1qonA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 12 TRP A  83
GLY A 150
SER A 238
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-1.9A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.89A 1dx6A-1qonA:
60.5		 1dx6A-1qonA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EVE_A_E20A2001_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 10 GLY A 151
GLU A 237
TRP A 321
PHE A 371
TYR A 374
HIS A 480
 SO4  A 593 (-3.4A)
I40  A 997 (-4.2A)
None
I40  A 997 (-4.9A)
I40  A 997 ( 3.9A)
SO4  A 593 (-4.1A)
 1.49A 1eveA-1qonA:
60.7		 1eveA-1qonA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EVE_A_E20A2001_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 10 TRP A  83
GLY A 150
GLU A 237
TRP A 321
PHE A 371
TYR A 374
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
None
I40  A 997 (-4.9A)
I40  A 997 ( 3.9A)
SO4  A 593 (-4.1A)
 0.73A 1eveA-1qonA:
60.7		 1eveA-1qonA:
38.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 7 SER A 241
VAL A 364
THR A 266
THR A 444
 None
 0.77A 1gtnC-1qonA:
undetectable
1gtnD-1qonA:
undetectable		 1gtnC-1qonA:
8.78
1gtnD-1qonA:
8.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 12 GLY A 151
GLU A 237
SER A 238
TRP A 321
HIS A 480
 SO4  A 593 (-3.4A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
None
SO4  A 593 (-4.1A)
 1.37A 1maaA-1qonA:
52.4		 1maaA-1qonA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 12 TRP A  83
GLY A 150
GLU A 237
SER A 238
PHE A 330
TYR A 374
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
I40  A 997 ( 3.9A)
SO4  A 593 (-4.1A)
 0.62A 1maaA-1qonA:
52.4		 1maaA-1qonA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 12 TRP A  83
GLY A 150
GLU A 237
SER A 238
TRP A 321
PHE A 330
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
None
I40  A 997 ( 4.1A)
SO4  A 593 (-4.1A)
 0.68A 1maaA-1qonA:
52.4		 1maaA-1qonA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 12 TRP A  83
GLY A 150
GLU A 237
TRP A 321
PHE A 330
TYR A 370
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
None
I40  A 997 ( 4.1A)
I40  A 997 (-3.9A)
 1.06A 1maaA-1qonA:
52.4		 1maaA-1qonA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		8 / 12 TRP A  83
GLY A 150
TYR A 162
SER A 238
PHE A 330
PHE A 371
TYR A 374
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
None
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
I40  A 997 ( 3.9A)
SO4  A 593 (-4.1A)
 0.79A 1maaC-1qonA:
56.9		 1maaC-1qonA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		8 / 12 TRP A  83
GLY A 150
TYR A 162
SER A 238
TRP A 321
PHE A 330
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
None
SO4  A 593 (-1.9A)
None
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.72A 1maaC-1qonA:
56.9		 1maaC-1qonA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 12 TRP A  83
GLY A 150
TYR A 162
TRP A 321
PHE A 330
TYR A 370
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
None
None
I40  A 997 ( 4.1A)
I40  A 997 (-3.9A)
 1.02A 1maaC-1qonA:
56.9		 1maaC-1qonA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 8 GLY A 151
GLU A 237
SER A 238
TRP A 321
HIS A 480
 SO4  A 593 (-3.4A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
None
SO4  A 593 (-4.1A)
 1.37A 1maaD-1qonA:
52.4		 1maaD-1qonA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 8 TRP A  83
GLY A 150
GLU A 237
SER A 238
TRP A 321
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
None
SO4  A 593 (-4.1A)
 0.69A 1maaD-1qonA:
52.4		 1maaD-1qonA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 8 TRP A  83
GLY A 150
GLU A 237
SER A 238
TYR A 374
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 ( 3.9A)
SO4  A 593 (-4.1A)
 0.53A 1maaD-1qonA:
52.4		 1maaD-1qonA:
39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 12 GLY A 150
GLY A 151
SER A 238
PHE A 440
HIS A 480
 I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
 0.51A 1mx1D-1qonA:
47.2		 1mx1D-1qonA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 12 GLY A 150
GLY A 151
SER A 238
PHE A 440
HIS A 480
 I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
 0.48A 1mx1F-1qonA:
47.5		 1mx1F-1qonA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 11 ILE A  32
ALA A  59
VAL A  14
ARG A  15
ALA A 224
 None
 1.04A 1n4hA-1qonA:
undetectable		 1n4hA-1qonA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 5 SER A 238
SER A 242
PHE A 371
PHE A 152
 SO4  A 593 (-1.9A)
None
I40  A 997 (-4.9A)
None
 1.46A 1oipA-1qonA:
0.4		 1oipA-1qonA:
17.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 12 GLY A 149
GLY A 151
GLU A 237
SER A 238
PHE A 371
PHE A 330
 SO4  A 593 ( 4.2A)
SO4  A 593 (-3.4A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 (-4.9A)
I40  A 997 ( 4.1A)
 1.10A 1qtiA-1qonA:
55.7		 1qtiA-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 12 GLY A 240
GLU A 237
SER A 238
PHE A 330
PHE A 371
HIS A 480
 None
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.32A 1qtiA-1qonA:
55.7		 1qtiA-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		9 / 12 TRP A  83
GLY A 149
GLY A 150
GLY A 151
GLU A 237
SER A 238
PHE A 330
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.55A 1qtiA-1qonA:
55.7		 1qtiA-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 12 TRP A  83
GLY A 150
SER A 238
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-1.9A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.93A 1qtiA-1qonA:
55.7		 1qtiA-1qonA:
37.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 8 PHE A 330
SER A 329
LEU A 328
ILE A 327
 I40  A 997 ( 4.1A)
None
None
None
 0.87A 1sbrA-1qonA:
0.0		 1sbrA-1qonA:
15.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U65_A_CP0A1000_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 11 TRP A  83
GLU A 237
TRP A 321
TYR A 374
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-4.2A)
None
I40  A 997 ( 3.9A)
SO4  A 593 (-4.1A)
 0.68A 1u65A-1qonA:
56.1		 1u65A-1qonA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 12 GLY A 240
GLY A 151
SER A 238
PHE A 330
PHE A 371
HIS A 480
 None
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.31A 1w6rA-1qonA:
60.3		 1w6rA-1qonA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		8 / 12 TRP A  83
GLY A 149
GLY A 150
GLY A 151
SER A 238
PHE A 330
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.56A 1w6rA-1qonA:
60.3		 1w6rA-1qonA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 12 TRP A  83
GLY A 150
SER A 238
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-1.9A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.91A 1w6rA-1qonA:
60.3		 1w6rA-1qonA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		8 / 11 TRP A  83
GLY A 150
GLY A 151
GLU A 237
SER A 238
PHE A 330
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.50A 1w76A-1qonA:
56.3		 1w76A-1qonA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 10 GLY A 151
GLU A 237
SER A 238
PHE A 371
HIS A 480
 SO4  A 593 (-3.4A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.99A 1w76B-1qonA:
56.1		 1w76B-1qonA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 10 GLY A 240
GLU A 237
SER A 238
PHE A 330
PHE A 371
HIS A 480
 None
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.29A 1w76B-1qonA:
56.1		 1w76B-1qonA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		8 / 10 TRP A  83
GLY A 149
GLY A 150
GLU A 237
SER A 238
PHE A 330
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.46A 1w76B-1qonA:
56.1		 1w76B-1qonA:
38.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 8 GLY A 149
GLY A 150
GLY A 151
SER A 238
ALA A 239
HIS A 480
 SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
SO4  A 593 (-3.2A)
SO4  A 593 (-4.1A)
 0.37A 1yajC-1qonA:
47.0		 1yajC-1qonA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 8 GLY A 150
GLY A 151
SER A 238
ALA A 239
HIS A 480
 I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
SO4  A 593 (-3.2A)
SO4  A 593 (-4.1A)
 0.95A 1yajC-1qonA:
47.0		 1yajC-1qonA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 8 GLY A 240
GLY A 149
GLY A 150
SER A 238
ALA A 239
HIS A 480
 None
SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-1.9A)
SO4  A 593 (-3.2A)
SO4  A 593 (-4.1A)
 1.18A 1yajC-1qonA:
47.0		 1yajC-1qonA:
29.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 9 GLY A 149
GLY A 150
SER A 238
ALA A 239
HIS A 480
 SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-1.9A)
SO4  A 593 (-3.2A)
SO4  A 593 (-4.1A)
 0.84A 2aceA-1qonA:
61.0		 2aceA-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 9 GLY A 149
GLY A 150
SER A 238
ALA A 239
PHE A 371
 SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-1.9A)
SO4  A 593 (-3.2A)
I40  A 997 (-4.9A)
 0.94A 2aceA-1qonA:
61.0		 2aceA-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 9 GLY A 150
GLY A 151
SER A 238
ALA A 239
PHE A 371
 I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
SO4  A 593 (-3.2A)
I40  A 997 (-4.9A)
 0.77A 2aceA-1qonA:
61.0		 2aceA-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 9 GLY A 150
GLY A 151
SER A 238
ALA A 239
TRP A 271
PHE A 330
HIS A 480
 I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
SO4  A 593 (-3.2A)
SO4  A 593 (-4.4A)
I40  A 997 ( 4.1A)
SO4  A 593 (-4.1A)
 0.38A 2aceA-1qonA:
61.0		 2aceA-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 7 TRP A  83
GLY A 149
GLU A 237
SER A 238
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
SO4  A 593 ( 4.2A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.25A 2ackA-1qonA:
61.0		 2ackA-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 7 TRP A  83
GLY A 150
GLU A 237
SER A 238
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.63A 2ackA-1qonA:
61.0		 2ackA-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 8 TRP A  83
TYR A 162
GLU A 237
PHE A 371
HIS A 480
GLY A 481
 I40  A 997 (-3.2A)
None
I40  A 997 (-4.2A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 0.40A 2ha4A-1qonA:
56.4		 2ha4A-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 8 TRP A  83
TYR A 162
GLU A 237
TYR A 370
GLY A 481
 I40  A 997 (-3.2A)
None
I40  A 997 (-4.2A)
I40  A 997 (-3.9A)
I40  A 997 ( 4.3A)
 0.87A 2ha4A-1qonA:
56.4		 2ha4A-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 8 TYR A  71
TYR A 162
GLU A 237
PHE A 371
HIS A 480
GLY A 481
 I40  A 997 ( 3.8A)
None
I40  A 997 (-4.2A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 1.39A 2ha4A-1qonA:
56.4		 2ha4A-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 8 GLY A 149
GLY A 150
ALA A 239
PHE A 371
HIS A 480
 SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-3.2A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.09A 2ha4A-1qonA:
56.4		 2ha4A-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 8 GLY A 150
ALA A 239
TRP A 271
PHE A 440
HIS A 480
 I40  A 997 (-3.9A)
SO4  A 593 (-3.2A)
SO4  A 593 (-4.4A)
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
 1.46A 2ha4A-1qonA:
56.4		 2ha4A-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 8 GLY A 150
GLY A 151
ALA A 239
PHE A 371
HIS A 480
 I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-3.2A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.15A 2ha4A-1qonA:
56.4		 2ha4A-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 8 GLY A 150
GLY A 151
ALA A 239
TRP A 271
PHE A 330
HIS A 480
 I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-3.2A)
SO4  A 593 (-4.4A)
I40  A 997 ( 4.1A)
SO4  A 593 (-4.1A)
 0.43A 2ha4A-1qonA:
56.4		 2ha4A-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 7 TRP A  83
TYR A 162
GLU A 237
HIS A 480
GLY A 481
 I40  A 997 (-3.2A)
None
I40  A 997 (-4.2A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 0.33A 2ha4B-1qonA:
61.2		 2ha4B-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 7 TRP A  83
TYR A 162
GLU A 237
TYR A 370
GLY A 481
 I40  A 997 (-3.2A)
None
I40  A 997 (-4.2A)
I40  A 997 (-3.9A)
I40  A 997 ( 4.3A)
 0.92A 2ha4B-1qonA:
61.2		 2ha4B-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 7 TYR A  71
TYR A 162
GLU A 237
HIS A 480
GLY A 481
 I40  A 997 ( 3.8A)
None
I40  A 997 (-4.2A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 1.31A 2ha4B-1qonA:
61.2		 2ha4B-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 7 GLY A 150
GLY A 151
ALA A 239
TRP A 271
PHE A 330
HIS A 480
 I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-3.2A)
SO4  A 593 (-4.4A)
I40  A 997 ( 4.1A)
SO4  A 593 (-4.1A)
 0.44A 2ha4B-1qonA:
61.2		 2ha4B-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 10 GLU A  81
ASN A  84
ASP A 160
GLU A 485
LEU A 496
TYR A 498
 None
None
None
None
NAG  A 991 (-4.1A)
None
 0.79A 2ha6A-1qonA:
56.8		 2ha6A-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 10 GLU A  81
ASN A  84
THR A 469
GLU A 485
LEU A 496
TYR A 498
 None
None
None
None
NAG  A 991 (-4.1A)
None
 0.93A 2ha6A-1qonA:
56.8		 2ha6A-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA6_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 9 TRP A  83
PHE A 371
TYR A 374
HIS A 480
GLY A 481
 I40  A 997 (-3.2A)
I40  A 997 (-4.9A)
I40  A 997 ( 3.9A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 0.42A 2ha6B-1qonA:
63.1		 2ha6B-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA6_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 9 TRP A  83
TRP A 321
PHE A 371
HIS A 480
GLY A 481
 I40  A 997 (-3.2A)
None
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 0.51A 2ha6B-1qonA:
63.1		 2ha6B-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 10 GLU A  81
ASN A  84
ASP A 160
GLU A 485
LEU A 496
TYR A 498
 None
None
None
None
NAG  A 991 (-4.1A)
None
 0.79A 2ha6B-1qonA:
63.1		 2ha6B-1qonA:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 10 GLU A  81
ASN A  84
THR A 469
GLU A 485
LEU A 496
TYR A 498
 None
None
None
None
NAG  A 991 (-4.1A)
None
 0.90A 2ha6B-1qonA:
63.1		 2ha6B-1qonA:
38.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 11 THR A 154
GLY A 151
PHE A 330
PHE A 371
HIS A 480
 None
SO4  A 593 (-3.4A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.43A 2y7kA-1qonA:
undetectable		 2y7kA-1qonA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 10 THR A 154
GLY A 151
PHE A 330
PHE A 371
HIS A 480
 None
SO4  A 593 (-3.4A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.31A 2y7kB-1qonA:
undetectable		 2y7kB-1qonA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 7 THR A 154
GLY A 151
PHE A 330
PHE A 371
HIS A 480
 None
SO4  A 593 (-3.4A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.17A 2y7wC-1qonA:
undetectable		 2y7wC-1qonA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		3 / 3 SER A 470
GLY A 473
GLY A 477
 None
 0.39A 3bogA-1qonA:
undetectable
3bogC-1qonA:
undetectable		 3bogA-1qonA:
undetectable
3bogC-1qonA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		3 / 3 TYR A 180
GLU A 237
ASP A 482
 None
I40  A 997 (-4.2A)
None
 0.68A 3bxoA-1qonA:
undetectable		 3bxoA-1qonA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		3 / 3 TYR A 180
GLU A 237
ASP A 482
 None
I40  A 997 (-4.2A)
None
 0.66A 3bxoB-1qonA:
undetectable		 3bxoB-1qonA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 8 GLY A 183
PHE A 439
PHE A 440
GLY A 150
 None
None
SO4  A 593 (-4.5A)
I40  A 997 (-3.9A)
 0.94A 3ko0O-1qonA:
1.1
3ko0Q-1qonA:
0.0		 3ko0O-1qonA:
13.01
3ko0Q-1qonA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 8 PHE A 178
ALA A 214
ALA A 212
THR A 253
 None
 1.06A 3l4dD-1qonA:
undetectable		 3l4dD-1qonA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 7 LEU A 348
LEU A 341
SER A 243
ASN A 245
 None
 0.79A 3lm8A-1qonA:
undetectable
3lm8C-1qonA:
undetectable		 3lm8A-1qonA:
17.58
3lm8C-1qonA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 7 LEU A 348
LEU A 341
SER A 243
ASN A 245
 None
 0.82A 3lm8B-1qonA:
undetectable
3lm8D-1qonA:
0.8		 3lm8B-1qonA:
17.58
3lm8D-1qonA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 8 LEU A 348
LEU A 341
SER A 243
ASN A 245
 None
 0.97A 3lm8A-1qonA:
undetectable
3lm8C-1qonA:
undetectable		 3lm8A-1qonA:
17.58
3lm8C-1qonA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 8 LEU A 348
LEU A 341
SER A 243
ASN A 245
 None
 0.83A 3lm8B-1qonA:
undetectable
3lm8D-1qonA:
undetectable		 3lm8B-1qonA:
17.58
3lm8D-1qonA:
17.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 7 GLY A 149
GLY A 150
SER A 238
PHE A 440
HIS A 480
 SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-1.9A)
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
 1.16A 3o9mA-1qonA:
59.6		 3o9mA-1qonA:
37.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 7 GLY A 149
SER A 238
TRP A 271
PHE A 440
HIS A 480
 SO4  A 593 ( 4.2A)
SO4  A 593 (-1.9A)
SO4  A 593 (-4.4A)
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
 0.93A 3o9mA-1qonA:
59.6		 3o9mA-1qonA:
37.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 7 GLY A 150
GLY A 151
SER A 238
TRP A 271
LEU A 328
PHE A 440
HIS A 480
 I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
SO4  A 593 (-4.4A)
None
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
 0.44A 3o9mA-1qonA:
59.6		 3o9mA-1qonA:
37.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 6 GLY A 150
GLY A 151
SER A 238
TRP A 271
LEU A 328
HIS A 480
 I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
SO4  A 593 (-4.4A)
None
SO4  A 593 (-4.1A)
 0.51A 3o9mB-1qonA:
59.7		 3o9mB-1qonA:
37.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 12 TYR A 447
ALA A 246
SER A 241
MET A 262
LEU A 208
 None
 1.44A 3ou6D-1qonA:
undetectable		 3ou6D-1qonA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 5 LEU A 510
GLY A 489
PHE A 235
ASN A 163
 None
None
None
NAG  A 991 ( 4.6A)
 1.26A 3uq6B-1qonA:
undetectable		 3uq6B-1qonA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BDS_A_THAA701_1
(CHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 9 TRP A  83
GLU A 237
SER A 238
TYR A 374
TRP A 472
HIS A 480
GLY A 481
 I40  A 997 (-3.2A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 ( 3.9A)
I40  A 997 (-4.0A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 0.33A 4bdsA-1qonA:
57.5		 4bdsA-1qonA:
39.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 12 GLY A 149
GLY A 150
GLY A 151
SER A 238
PHE A 371
HIS A 480
 SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.12A 4ey6A-1qonA:
63.2		 4ey6A-1qonA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 12 GLY A 240
GLY A 151
SER A 238
PHE A 330
PHE A 371
HIS A 480
 None
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.25A 4ey6A-1qonA:
63.2		 4ey6A-1qonA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 12 TRP A  83
GLY A 149
GLY A 150
GLY A 151
PHE A 330
TYR A 370
PHE A 371
 I40  A 997 (-3.2A)
SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
I40  A 997 ( 4.1A)
I40  A 997 (-3.9A)
I40  A 997 (-4.9A)
 0.82A 4ey6A-1qonA:
63.2		 4ey6A-1qonA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		8 / 12 TRP A  83
GLY A 149
GLY A 150
GLY A 151
SER A 238
PHE A 330
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.53A 4ey6A-1qonA:
63.2		 4ey6A-1qonA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 12 TRP A  83
GLY A 150
SER A 238
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-1.9A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.83A 4ey6A-1qonA:
63.2		 4ey6A-1qonA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 12 GLY A 149
GLY A 150
GLY A 151
GLU A 237
SER A 238
PHE A 371
HIS A 480
 SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.09A 4ey6B-1qonA:
52.8		 4ey6B-1qonA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		9 / 12 TRP A  83
GLY A 149
GLY A 150
GLY A 151
GLU A 237
SER A 238
PHE A 330
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.55A 4ey6B-1qonA:
52.8		 4ey6B-1qonA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 12 TRP A  83
GLY A 149
GLY A 150
GLY A 151
PHE A 330
TYR A 370
 I40  A 997 (-3.2A)
SO4  A 593 ( 4.2A)
I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
I40  A 997 ( 4.1A)
I40  A 997 (-3.9A)
 0.87A 4ey6B-1qonA:
52.8		 4ey6B-1qonA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 12 TRP A  83
GLY A 150
GLU A 237
SER A 238
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.83A 4ey6B-1qonA:
52.8		 4ey6B-1qonA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 11 TRP A  83
GLY A 150
GLU A 237
SER A 238
TRP A 321
HIS A 480
GLY A 481
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
None
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 0.79A 4ey7A-1qonA:
63.0		 4ey7A-1qonA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 11 TRP A  83
GLY A 150
GLU A 237
SER A 238
TYR A 374
HIS A 480
GLY A 481
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 ( 3.9A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 0.59A 4ey7A-1qonA:
63.0		 4ey7A-1qonA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 11 GLY A 151
GLU A 237
SER A 238
TRP A 321
HIS A 480
 SO4  A 593 (-3.4A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
None
SO4  A 593 (-4.1A)
 1.42A 4ey7B-1qonA:
57.1		 4ey7B-1qonA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 11 TRP A  83
GLY A 150
GLU A 237
SER A 238
TRP A 321
HIS A 480
GLY A 481
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
None
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 0.80A 4ey7B-1qonA:
57.1		 4ey7B-1qonA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 11 TRP A  83
GLY A 150
GLU A 237
SER A 238
TYR A 374
HIS A 480
GLY A 481
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 ( 3.9A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 0.61A 4ey7B-1qonA:
57.1		 4ey7B-1qonA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 11 TYR A  73
TRP A  83
GLU A 237
SER A 238
HIS A 480
GLY A 481
 None
I40  A 997 (-3.2A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 1.49A 4ey7B-1qonA:
57.1		 4ey7B-1qonA:
36.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 8 ILE A 327
PHE A 401
TRP A 563
GLY A 432
 None
 0.94A 4fgjA-1qonA:
undetectable
4fgjB-1qonA:
undetectable		 4fgjA-1qonA:
17.33
4fgjB-1qonA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 5 MET A 194
LEU A 297
ARG A 309
SER A 276
 None
 1.27A 4kmmB-1qonA:
3.2		 4kmmB-1qonA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 4 ILE A  82
SER A  78
ASP A 482
ASP A 366
 None
 1.32A 4krhB-1qonA:
2.1		 4krhB-1qonA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 6 ARG A  70
ASN A  88
GLY A  61
THR A  65
 None
None
BMA  A 996 (-2.6A)
None
 1.09A 4l1aB-1qonA:
undetectable		 4l1aB-1qonA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 7 TYR A  71
GLN A 263
THR A 444
MET A 476
 I40  A 997 ( 3.8A)
None
None
None
 0.95A 4mbsA-1qonA:
undetectable		 4mbsA-1qonA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 12 ASP A 366
VAL A 478
SER A 264
ASP A 437
LEU A 556
 None
 1.31A 4pevC-1qonA:
3.6		 4pevC-1qonA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 12 TRP A 271
SER A 242
GLY A 481
PHE A 371
GLY A 436
 SO4  A 593 (-4.4A)
None
I40  A 997 ( 4.3A)
I40  A 997 (-4.9A)
None
 1.41A 4uinH-1qonA:
undetectable
4uinL-1qonA:
undetectable		 4uinH-1qonA:
16.52
4uinL-1qonA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 6 ARG A 433
ASP A 437
VAL A 478
ASP A 366
 None
 1.33A 4xqeA-1qonA:
2.0		 4xqeA-1qonA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 6 ARG A 433
ASP A 437
VAL A 478
ASP A 366
 None
 1.36A 4xqeB-1qonA:
2.3		 4xqeB-1qonA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 6 SER A  90
GLU A  91
GLY A  61
GLY A  31
 None
None
BMA  A 996 (-2.6A)
None
 0.77A 5cdnA-1qonA:
undetectable
5cdnB-1qonA:
undetectable		 5cdnA-1qonA:
22.73
5cdnB-1qonA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 6 SER A  90
GLU A  91
GLY A  61
GLY A  31
 None
None
BMA  A 996 (-2.6A)
None
 0.78A 5cdnR-1qonA:
undetectable
5cdnS-1qonA:
undetectable		 5cdnR-1qonA:
22.73
5cdnS-1qonA:
14.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 6 ASP A 375
TYR A  73
PHE A 330
TYR A 324
 None
None
I40  A 997 ( 4.1A)
None
 1.18A 5e2iA-1qonA:
60.6		 5e2iA-1qonA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E4J_A_DMEA608_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		6 / 9 TRP A  83
GLU A 237
TRP A 321
TYR A 374
HIS A 480
GLY A 481
 I40  A 997 (-3.2A)
I40  A 997 (-4.2A)
None
I40  A 997 ( 3.9A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 0.68A 5e4jA-1qonA:
60.3		 5e4jA-1qonA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E4J_A_DMEA608_1
(ACETYLCHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 9 TYR A  73
TRP A  83
GLU A 237
HIS A 480
GLY A 481
 None
I40  A 997 (-3.2A)
I40  A 997 (-4.2A)
SO4  A 593 (-4.1A)
I40  A 997 ( 4.3A)
 1.49A 5e4jA-1qonA:
60.3		 5e4jA-1qonA:
37.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 8 PHE A  77
GLY A  79
TRP A  83
ASP A 482
 None
None
I40  A 997 (-3.2A)
None
 0.93A 5gqbA-1qonA:
undetectable		 5gqbA-1qonA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		3 / 3 ILE A  32
PRO A  33
ILE A  96
 None
 0.44A 5hw8F-1qonA:
undetectable		 5hw8F-1qonA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 6 SER A 241
GLY A 362
ASN A 363
ILE A 359
 None
 0.88A 5j4nA-1qonA:
undetectable		 5j4nA-1qonA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 6 VAL A 304
SER A 306
ARG A  45
PHE A  44
 None
 1.02A 5jw1B-1qonA:
undetectable		 5jw1B-1qonA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 10 SER A  90
ASP A  92
PRO A  38
LEU A  94
SER A 156
 None
 1.45A 5l1fD-1qonA:
2.4		 5l1fD-1qonA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 6 LEU A 360
ILE A 143
THR A 233
MET A 167
 None
 1.43A 5ljeA-1qonA:
undetectable		 5ljeA-1qonA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		3 / 3 SER A 238
SER A 242
PHE A 371
 SO4  A 593 (-1.9A)
None
I40  A 997 (-4.9A)
 0.88A 5mugA-1qonA:
undetectable		 5mugA-1qonA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 6 PRO A 270
TYR A 416
PHE A 401
LEU A 567
 None
 1.13A 5tl8A-1qonA:
0.0		 5tl8A-1qonA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		3 / 3 LEU A 286
ALA A 285
LEU A 188
 None
 0.52A 5uunB-1qonA:
undetectable		 5uunB-1qonA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		3 / 3 GLU A 483
TRP A 146
HIS A 480
 None
None
SO4  A 593 (-4.1A)
 1.11A 5xipA-1qonA:
undetectable		 5xipA-1qonA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 12 GLY A 207
GLY A 186
ASN A 205
SER A 332
PHE A 340
 None
 1.32A 5yf0A-1qonA:
undetectable		 5yf0A-1qonA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 12 ALA A 448
PHE A 178
ALA A 214
ALA A 212
THR A 253
 None
 1.04A 6aycA-1qonA:
undetectable		 6aycA-1qonA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 5 TYR A 148
GLN A 179
THR A 158
LEU A 159
 None
 1.17A 6d8pA-1qonA:
1.6		 6d8pA-1qonA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 6 LEU A 479
TYR A 162
GLN A 211
GLU A 237
 None
None
None
I40  A 997 (-4.2A)
 1.42A 6djzC-1qonA:
undetectable		 6djzC-1qonA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 5 TRP A  83
TYR A 162
GLU A 237
TYR A 374
HIS A 480
 I40  A 997 (-3.2A)
None
I40  A 997 (-4.2A)
I40  A 997 ( 3.9A)
SO4  A 593 (-4.1A)
 0.50A 6ep4A-1qonA:
60.6		 6ep4A-1qonA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 8 GLY A 150
SER A 238
PHE A 371
TYR A 374
 I40  A 997 (-3.9A)
SO4  A 593 (-1.9A)
I40  A 997 (-4.9A)
I40  A 997 ( 3.9A)
 0.77A 6eqpA-1qonA:
59.8		 6eqpA-1qonA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		7 / 8 TRP A  83
GLY A 151
THR A 154
SER A 238
TRP A 271
PHE A 371
TYR A 374
 I40  A 997 (-3.2A)
SO4  A 593 (-3.4A)
None
SO4  A 593 (-1.9A)
SO4  A 593 (-4.4A)
I40  A 997 (-4.9A)
I40  A 997 ( 3.9A)
 0.65A 6eqpA-1qonA:
59.8		 6eqpA-1qonA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		4 / 6 GLU A 528
TRP A 529
ALA A 523
GLN A 524
 None
 1.30A 6f6jC-1qonA:
undetectable
6f6jD-1qonA:
undetectable		 6f6jC-1qonA:
20.70
6f6jD-1qonA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0F_H_Y70H502_0
(IKAROS (IKZF1)
PROTEIN CEREBLON)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 12 ASN A 268
HIS A 273
TRP A 271
ASN A 245
GLY A 265
 None
None
SO4  A 593 (-4.4A)
None
None
 1.49A 6h0fH-1qonA:
0.0
6h0fI-1qonA:
0.0		 6h0fH-1qonA:
9.34
6h0fI-1qonA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0F_K_Y70K502_0
(IKAROS (IKZF1)
PROTEIN CEREBLON)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 12 ASN A 268
HIS A 273
TRP A 271
ASN A 245
GLY A 265
 None
None
SO4  A 593 (-4.4A)
None
None
 1.48A 6h0fK-1qonA:
0.0
6h0fL-1qonA:
0.0		 6h0fK-1qonA:
9.34
6h0fL-1qonA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 11 GLY A 151
SER A 238
PHE A 330
PHE A 440
HIS A 480
 SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
 1.21A 6qgbA-1qonA:
11.4		 6qgbA-1qonA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_B_BEZB802_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 10 GLY A 151
SER A 238
PHE A 330
PHE A 440
HIS A 480
 SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
 1.19A 6qgbB-1qonA:
11.2		 6qgbB-1qonA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_C_BEZC701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 9 GLY A 151
SER A 238
PHE A 330
PHE A 440
HIS A 480
 SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
 1.19A 6qgbC-1qonA:
11.3		 6qgbC-1qonA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 10 GLY A 151
SER A 238
PHE A 330
PHE A 440
HIS A 480
 SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
 1.19A 6qgbD-1qonA:
11.6		 6qgbD-1qonA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 11 GLY A 151
SER A 238
PHE A 330
PHE A 440
HIS A 480
 SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
 1.20A 6qgbE-1qonA:
11.7		 6qgbE-1qonA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1qon ACETYLCHOLINESTERASE
(Drosophila
melanogaster) 		5 / 10 GLY A 151
SER A 238
PHE A 330
PHE A 440
HIS A 480
 SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
I40  A 997 ( 4.1A)
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
 1.21A 6qgbF-1qonA:
0.0		 6qgbF-1qonA:
23.49