SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qp8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 11 ASN A 293
LEU A  36
ALA A  79
GLY A  80
PHE A   7
 None
None
NDP  A 310 (-3.0A)
NDP  A 310 ( 4.8A)
None
 1.45A 1l5rA-1qp8A:
2.4		 1l5rA-1qp8A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 LEU A  91
ALA A  90
LEU A  94
ALA A 178
VAL A 129
 None
 1.18A 1sa1C-1qp8A:
0.9
1sa1D-1qp8A:
1.3		 1sa1C-1qp8A:
19.09
1sa1D-1qp8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 LEU A 215
VAL A 255
LEU A 224
LEU A 221
VAL A 192
 None
 1.13A 1sn5B-1qp8A:
0.0
1sn5D-1qp8A:
0.0		 1sn5B-1qp8A:
18.77
1sn5D-1qp8A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 LEU A 224
LEU A 221
VAL A 192
LEU A 215
VAL A 255
 None
 1.13A 1sn5B-1qp8A:
0.0
1sn5D-1qp8A:
0.0		 1sn5B-1qp8A:
18.77
1sn5D-1qp8A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 SER A  81
ASN A  82
THR A 156
ALA A 295
VAL A  56
 None
NDP  A 310 (-3.5A)
NDP  A 310 (-2.4A)
None
None
 1.27A 2nniA-1qp8A:
undetectable		 2nniA-1qp8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		4 / 6 LEU A  64
LEU A  61
ILE A  40
ARG A  39
 None
 1.06A 2rlfB-1qp8A:
0.0
2rlfC-1qp8A:
0.0		 2rlfB-1qp8A:
11.03
2rlfC-1qp8A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 GLY A 133
GLU A 134
ASN A  78
ALA A  59
ASP A  84
 NDP  A 310 (-4.5A)
None
None
NDP  A 310 (-3.4A)
None
 1.16A 2vdvE-1qp8A:
4.2		 2vdvE-1qp8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 11 GLY A 133
GLU A 134
ASN A  78
ALA A  59
ASP A  84
 NDP  A 310 (-4.5A)
None
None
NDP  A 310 (-3.4A)
None
 1.17A 2vdvF-1qp8A:
4.1		 2vdvF-1qp8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		4 / 5 ARG A  25
PHE A  21
LEU A   9
PHE A   7
 None
 1.32A 2y69P-1qp8A:
0.9
2y69W-1qp8A:
0.0		 2y69P-1qp8A:
22.73
2y69W-1qp8A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 GLY A 131
GLY A 210
ARG A 138
ALA A  87
ASP A  84
 NDP  A 310 ( 4.1A)
NDP  A 310 ( 3.7A)
None
None
None
 1.00A 3keeA-1qp8A:
undetectable		 3keeA-1qp8A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 GLY A 131
GLY A 210
ARG A 138
ALA A  87
ASP A  84
 NDP  A 310 ( 4.1A)
NDP  A 310 ( 3.7A)
None
None
None
 1.05A 3keeD-1qp8A:
undetectable		 3keeD-1qp8A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		4 / 7 GLY A 210
ASN A 208
GLY A 136
THR A 137
 NDP  A 310 ( 3.7A)
None
NDP  A 310 ( 4.9A)
None
 0.79A 3tajA-1qp8A:
undetectable		 3tajA-1qp8A:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 11 ALA A 286
LEU A   3
THR A  74
ILE A  54
LEU A  51
 None
 1.09A 3tqbA-1qp8A:
undetectable		 3tqbA-1qp8A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 11 ALA A 286
LEU A 282
LEU A   3
ILE A  54
LEU A  51
 None
 1.06A 3tqbA-1qp8A:
undetectable		 3tqbA-1qp8A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		3 / 3 TYR A 265
HIS A  63
ARG A  39
 None
 1.06A 4htfA-1qp8A:
7.2		 4htfA-1qp8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		4 / 7 MET A 276
GLU A  12
GLU A  14
GLU A  15
 None
 1.21A 4mj8C-1qp8A:
undetectable		 4mj8C-1qp8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 231
ALA A 177
LEU A  95
ALA A  92
ILE A 119
 None
 1.05A 4psyA-1qp8A:
undetectable		 4psyA-1qp8A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 ALA A 204
ALA A 128
ARG A 151
LEU A 172
PHE A 232
 None
 1.30A 4zo1X-1qp8A:
undetectable		 4zo1X-1qp8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		4 / 5 GLU A 213
ASP A  62
VAL A 214
ALA A 212
 None
 1.44A 5dl9A-1qp8A:
undetectable		 5dl9A-1qp8A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		4 / 4 VAL A  32
GLU A   2
GLY A  30
LEU A  29
 None
 1.14A 5g5gC-1qp8A:
undetectable		 5g5gC-1qp8A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 VAL A 236
ASP A 235
GLN A 273
ARG A  39
GLY A 264
 NDP  A 310 (-4.2A)
NDP  A 310 (-4.4A)
None
None
None
 1.39A 5m50B-1qp8A:
2.2		 5m50B-1qp8A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		5 / 12 VAL A 236
ASP A 235
GLN A 273
ARG A  39
GLY A 264
 NDP  A 310 (-4.2A)
NDP  A 310 (-4.4A)
None
None
None
 1.34A 5m50E-1qp8A:
2.1		 5m50E-1qp8A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1qp8 FORMATE
DEHYDROGENASE
(Pyrobaculum
aerophilum) 		4 / 6 ARG A  25
PHE A  21
LEU A   9
PHE A   7
 None
 1.35A 6nmpC-1qp8A:
0.7
6nmpJ-1qp8A:
0.0		 6nmpC-1qp8A:
22.73
6nmpJ-1qp8A:
10.81