SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qpa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 1qpa LIGNIN PEROXIDASE
(Phanerochaete
chrysosporium) 		4 / 4 ALA A 316
ARG A 243
GLN A 315
GLU A 314
 None
 1.31A 1lqtB-1qpaA:
0.0		 1lqtB-1qpaA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 1qpa LIGNIN PEROXIDASE
(Phanerochaete
chrysosporium) 		4 / 4 ALA A 316
ARG A 243
GLN A 315
GLU A 314
 None
 1.33A 1lquB-1qpaA:
0.0		 1lquB-1qpaA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1qpa LIGNIN PEROXIDASE
(Phanerochaete
chrysosporium) 		4 / 8 ASP A  23
LYS A 100
GLY A 102
ASP A 107
 None
 1.00A 2aouA-1qpaA:
undetectable		 2aouA-1qpaA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 1qpa LIGNIN PEROXIDASE
(Phanerochaete
chrysosporium) 		4 / 6 LEU A  87
GLN A  94
GLU A  37
ILE A  93
 None
 1.07A 2fcnA-1qpaA:
0.0
2fcnB-1qpaA:
undetectable		 2fcnA-1qpaA:
13.19
2fcnB-1qpaA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1qpa LIGNIN PEROXIDASE
(Phanerochaete
chrysosporium) 		5 / 12 ALA A  41
GLY A 113
ASP A  23
VAL A  20
GLY A 106
 None
 0.84A 2qe6A-1qpaA:
undetectable		 2qe6A-1qpaA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1qpa LIGNIN PEROXIDASE
(Phanerochaete
chrysosporium) 		3 / 3 SER A  70
GLY A  66
GLY A  64
 CA  A 352 (-2.5A)
CA  A 352 (-4.4A)
None
 0.49A 3bogA-1qpaA:
undetectable
3bogC-1qpaA:
undetectable		 3bogA-1qpaA:
undetectable
3bogC-1qpaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1qpa LIGNIN PEROXIDASE
(Phanerochaete
chrysosporium) 		4 / 7 PRO A 290
ILE A 289
GLY A 116
VAL A 117
 None
 0.93A 4a3uB-1qpaA:
undetectable		 4a3uB-1qpaA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 1qpa LIGNIN PEROXIDASE
(Phanerochaete
chrysosporium) 		5 / 12 ILE A  93
PHE A 193
LEU A 235
LEU A  87
HIS A  47
 None
HEM  A 350 ( 4.9A)
HEM  A 350 (-4.8A)
None
None
 1.31A 4j03A-1qpaA:
undetectable		 4j03A-1qpaA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1qpa LIGNIN PEROXIDASE
(Phanerochaete
chrysosporium) 		3 / 3 ASP A  22
LEU A  21
PHE A  18
 None
 0.39A 4pthA-1qpaA:
undetectable		 4pthA-1qpaA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 1qpa LIGNIN PEROXIDASE
(Phanerochaete
chrysosporium) 		5 / 12 LEU A 261
LEU A 325
ILE A 313
THR A 196
LEU A 210
 None
None
None
CA  A 351 (-3.7A)
None
 1.38A 5ienA-1qpaA:
0.0		 5ienA-1qpaA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 1qpa LIGNIN PEROXIDASE
(Phanerochaete
chrysosporium) 		4 / 5 THR A 309
HIS A 310
ALA A 311
ASP A 312
 None
 1.31A 5mfxA-1qpaA:
undetectable		 5mfxA-1qpaA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1qpa LIGNIN PEROXIDASE
(Phanerochaete
chrysosporium) 		6 / 12 GLY A  65
GLY A 276
LEU A  56
GLY A  63
GLY A  64
PRO A 140
 None
 1.30A 5zhmB-1qpaA:
undetectable		 5zhmB-1qpaA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1qpa LIGNIN PEROXIDASE
(Phanerochaete
chrysosporium) 		4 / 5 VAL A 225
LEU A 240
VAL A 154
LEU A 173
 None
None
None
HEM  A 350 (-4.9A)
 1.03A 6bqgA-1qpaA:
undetectable		 6bqgA-1qpaA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1qpa LIGNIN PEROXIDASE
(Phanerochaete
chrysosporium) 		4 / 7 ILE A  24
GLY A 131
ARG A  43
ALA A 110
 None
None
HEM  A 350 (-3.1A)
None
 0.88A 6hd6B-1qpaA:
undetectable		 6hd6B-1qpaA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1qpa LIGNIN PEROXIDASE
(Phanerochaete
chrysosporium) 		4 / 7 ALA A 112
GLY A 113
LEU A  42
GLY A  32
 None
None
HEM  A 350 ( 3.9A)
None
 0.59A 6nm4A-1qpaA:
undetectable		 6nm4A-1qpaA:
22.59