SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qpo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 101
ASP A  22
MET A 285
LEU A  93
 None
 1.18A 1errB-1qpoA:
undetectable		 1errB-1qpoA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 235
ARG A 239
ILE A 219
 None
 0.67A 1uobA-1qpoA:
0.0		 1uobA-1qpoA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  80
LEU A   3
LEU A 114
LEU A 110
 None
 0.93A 2bfpB-1qpoA:
undetectable		 2bfpB-1qpoA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 226
THR A 229
VAL A 264
GLY A 263
 None
 1.05A 2p2fA-1qpoA:
2.0		 2p2fA-1qpoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 226
THR A 229
VAL A 264
GLY A 263
 None
 1.06A 2p2fB-1qpoA:
2.4		 2p2fB-1qpoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  63
ASN A  64
LEU A  67
GLY A  71
MET A  91
 None
 1.30A 2q7lA-1qpoA:
undetectable		 2q7lA-1qpoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 277
VAL A  84
THR A  47
 None
 0.84A 3cyxA-1qpoA:
0.0		 3cyxA-1qpoA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A  64
MET A 107
LEU A  56
LEU A  93
MET A  91
 None
 1.26A 3d90B-1qpoA:
undetectable		 3d90B-1qpoA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 114
SER A 115
ALA A  59
THR A  62
ALA A  11
 None
 1.02A 3mdtB-1qpoA:
undetectable		 3mdtB-1qpoA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 151
MET A 107
LEU A  60
 None
 0.85A 3vw1D-1qpoA:
0.0		 3vw1D-1qpoA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 136
HIS A 161
TYR A 266
 None
 1.32A 4fu8A-1qpoA:
undetectable		 4fu8A-1qpoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 136
HIS A 161
TYR A 266
 None
 1.29A 4fu9A-1qpoA:
undetectable		 4fu9A-1qpoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 118
SER A 115
VAL A  84
ARG A  83
 None
 1.13A 4ijiH-1qpoA:
undetectable		 4ijiH-1qpoA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  67
LEU A  60
LEU A 100
LEU A  93
ALA A  95
 None
 1.09A 4p65B-1qpoA:
undetectable
4p65D-1qpoA:
undetectable
4p65G-1qpoA:
undetectable
4p65H-1qpoA:
undetectable		 4p65B-1qpoA:
5.75
4p65D-1qpoA:
5.75
4p65G-1qpoA:
4.58
4p65H-1qpoA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 8 LEU A 283
LEU A  45
LEU A  67
TYR A  72
LEU A 100
 None
 1.47A 5jqbA-1qpoA:
undetectable
5jqbB-1qpoA:
0.0		 5jqbA-1qpoA:
22.00
5jqbB-1qpoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 8 ARG A  83
ILE A 281
ASP A  57
LEU A  56
GLY A  55
 None
 1.06A 5nooD-1qpoA:
undetectable		 5nooD-1qpoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A  42
LEU A  60
VAL A 111
GLU A  65
 None
 1.13A 5tudA-1qpoA:
0.0		 5tudA-1qpoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 218
LYS A 172
GLU A 201
LEU A 220
 None
 1.41A 5xooA-1qpoA:
undetectable		 5xooA-1qpoA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  45
VAL A 278
THR A  62
ALA A 103
TYR A  72
 None
 1.17A 6djzC-1qpoA:
undetectable		 6djzC-1qpoA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 186
VAL A 200
SER A 204
LEU A 208
ILE A 219
 None
 1.36A 6fdyU-1qpoA:
0.0		 6fdyU-1qpoA:
25.64