SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qqg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 1qqg INSULIN RECEPTOR
SUBSTRATE 1
(Homo
sapiens) 		4 / 6 LEU A  66
LEU A 113
ILE A  64
ARG A  43
 None
 1.03A 2rlfB-1qqgA:
0.0
2rlfC-1qqgA:
0.0		 2rlfB-1qqgA:
9.92
2rlfC-1qqgA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1qqg INSULIN RECEPTOR
SUBSTRATE 1
(Homo
sapiens) 		3 / 3 ARG A  20
GLU A  50
SER A  24
 None
 0.65A 2xkkA-1qqgA:
undetectable
2xkkC-1qqgA:
undetectable		 2xkkA-1qqgA:
16.25
2xkkC-1qqgA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1qqg INSULIN RECEPTOR
SUBSTRATE 1
(Homo
sapiens) 		3 / 3 THR A 252
ASN A 248
GLU A 162
 None
 0.72A 3v4tA-1qqgA:
0.0
3v4tC-1qqgA:
0.0		 3v4tA-1qqgA:
21.11
3v4tC-1qqgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 1qqg INSULIN RECEPTOR
SUBSTRATE 1
(Homo
sapiens) 		5 / 12 PHE A 194
ALA A 203
LEU A 185
PHE A 221
GLY A 232
 None
 1.28A 4kykA-1qqgA:
0.3
4kykB-1qqgA:
0.1		 4kykA-1qqgA:
19.53
4kykB-1qqgA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 1qqg INSULIN RECEPTOR
SUBSTRATE 1
(Homo
sapiens) 		5 / 12 PHE A 221
MET A 238
VAL A 166
ILE A 253
LEU A 206
 None
 1.23A 5im2A-1qqgA:
undetectable		 5im2A-1qqgA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 1qqg INSULIN RECEPTOR
SUBSTRATE 1
(Homo
sapiens) 		4 / 6 ARG A 213
PHE A 236
PHE A 222
ILE A 253
 None
 1.10A 5vceA-1qqgA:
undetectable		 5vceA-1qqgA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1qqg INSULIN RECEPTOR
SUBSTRATE 1
(Homo
sapiens) 		3 / 3 PHE A  70
ARG A 184
ALA A  85
 None
 0.94A 6ecfB-1qqgA:
undetectable		 6ecfB-1qqgA:
21.60