SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qqj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		4 / 8 MET A 270
PHE A 295
THR A 325
LEU A 327
 None
 1.30A 1ea1A-1qqjA:
undetectable		 1ea1A-1qqjA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		5 / 12 GLY A 387
VAL A 412
VAL A 375
LEU A 384
LEU A 303
 None
 1.02A 1mx1E-1qqjA:
undetectable		 1mx1E-1qqjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		5 / 10 SER A 254
GLY A 256
GLU A 243
SER A 165
ILE A 173
 None
 1.37A 1pw7A-1qqjA:
undetectable		 1pw7A-1qqjA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		5 / 8 ASP A 126
ILE A 259
ILE A 166
GLY A 256
ILE A 173
 CA  A 420 (-3.1A)
None
None
None
None
 1.27A 1sh9A-1qqjA:
undetectable		 1sh9A-1qqjA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		5 / 10 ASP A 233
GLY A 349
ILE A 259
LEU A 345
ALA A 203
 CA  A 420 (-3.6A)
CA  A 420 ( 4.5A)
None
None
None
 0.95A 1x7pA-1qqjA:
undetectable
1x7pB-1qqjA:
undetectable		 1x7pA-1qqjA:
20.19
1x7pB-1qqjA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		5 / 12 LEU A 196
ILE A 239
SER A 254
PHE A 255
ILE A 173
 None
 1.38A 1xotA-1qqjA:
undetectable		 1xotA-1qqjA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		5 / 9 GLY A  52
ALA A  54
SER A  56
LEU A  55
LEU A  73
 None
 1.14A 1y7iA-1qqjA:
undetectable		 1y7iA-1qqjA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		4 / 8 ASP A 233
LYS A 253
GLY A 349
GLU A 201
 CA  A 420 (-3.6A)
CAC  A2004 ( 2.8A)
CA  A 420 ( 4.5A)
CA  A 420 (-3.2A)
 0.82A 2ys6A-1qqjA:
undetectable		 2ys6A-1qqjA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		4 / 4 THR A 393
VAL A 390
GLY A 170
THR A 171
 None
 1.03A 3cflA-1qqjA:
undetectable		 3cflA-1qqjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		5 / 9 ALA A 312
ASP A 374
ILE A 373
GLY A 305
ILE A 314
 None
 1.07A 3nu4A-1qqjA:
undetectable		 3nu4A-1qqjA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		4 / 8 TYR A 244
GLN A 240
TYR A 128
TYR A 159
 None
CAC  A2004 (-2.8A)
CAC  A2004 ( 4.3A)
None
 0.79A 3po7A-1qqjA:
undetectable		 3po7A-1qqjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		3 / 3 TYR A 128
GLN A 132
TRP A 324
 CAC  A2004 ( 4.3A)
None
None
 1.10A 4kn2C-1qqjA:
undetectable		 4kn2C-1qqjA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		4 / 8 GLY A 343
THR A  66
LEU A 117
ASN A  68
 None
 1.03A 4m5mA-1qqjA:
undetectable		 4m5mA-1qqjA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		5 / 12 PRO A  18
GLN A 110
ALA A  35
ILE A  36
SER A   2
 None
 1.29A 4uroC-1qqjA:
undetectable		 4uroC-1qqjA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		4 / 4 LEU A 340
ILE A 225
HIS A 224
VAL A 206
 None
 1.23A 4xyzA-1qqjA:
undetectable		 4xyzA-1qqjA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		3 / 3 ASN A 318
LEU A 230
PHE A 295
 None
 0.80A 5dsgA-1qqjA:
undetectable		 5dsgA-1qqjA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		5 / 11 GLY A 256
ALA A 236
GLU A 243
SER A 165
ILE A 173
 None
 1.19A 5i3cC-1qqjA:
undetectable		 5i3cC-1qqjA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		5 / 11 LEU A 230
GLY A 349
ILE A 351
PHE A 405
ILE A 297
 None
CA  A 420 ( 4.5A)
None
None
None
 1.01A 6ebzA-1qqjA:
undetectable		 6ebzA-1qqjA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		5 / 11 LEU A 230
GLY A 349
ILE A 351
PHE A 405
ILE A 297
 None
CA  A 420 ( 4.5A)
None
None
None
 1.02A 6ebzB-1qqjA:
undetectable		 6ebzB-1qqjA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		5 / 11 LEU A 230
GLY A 349
ILE A 351
PHE A 405
ILE A 297
 None
CA  A 420 ( 4.5A)
None
None
None
 1.04A 6ebzC-1qqjA:
undetectable		 6ebzC-1qqjA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		5 / 11 LEU A 230
GLY A 349
ILE A 351
PHE A 405
ILE A 297
 None
CA  A 420 ( 4.5A)
None
None
None
 1.00A 6ebzD-1qqjA:
undetectable		 6ebzD-1qqjA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		4 / 7 LEU A  67
PHE A  50
LEU A  88
GLY A  20
 None
 0.80A 6eu9D-1qqjA:
undetectable		 6eu9D-1qqjA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1qqj FUMARYLACETOACETATE
HYDROLASE
(Mus
musculus) 		5 / 11 LEU A 230
GLY A 349
ILE A 351
PHE A 405
ILE A 297
 None
CA  A 420 ( 4.5A)
None
None
None
 1.02A 6gp2A-1qqjA:
undetectable		 6gp2A-1qqjA:
11.35