SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qrz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1qrz PLASMINOGEN
(Homo
sapiens) 		5 / 10 VAL A 598
LEU A 652
PRO A 664
GLN A 631
VAL A 662
 None
 1.44A 1fdwA-1qrzA:
undetectable		 1fdwA-1qrzA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 1qrz PLASMINOGEN
(Homo
sapiens) 		3 / 3 ARG A 776
THR A 678
VAL A 674
 None
 0.94A 1hxbA-1qrzA:
0.4		 1hxbA-1qrzA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1qrz PLASMINOGEN
(Homo
sapiens) 		5 / 12 ILE A 682
THR A 759
ALA A 601
GLY A 590
LEU A 697
 None
 1.10A 1rjdA-1qrzA:
undetectable		 1rjdA-1qrzA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1qrz PLASMINOGEN
(Homo
sapiens) 		5 / 12 ILE A 682
THR A 759
ALA A 601
GLY A 590
LEU A 697
 None
 1.08A 1rjdB-1qrzA:
undetectable		 1rjdB-1qrzA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1qrz PLASMINOGEN
(Homo
sapiens) 		5 / 12 ILE A 682
THR A 759
ALA A 601
GLY A 590
LEU A 697
 None
 1.09A 1rjdC-1qrzA:
undetectable		 1rjdC-1qrzA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1qrz PLASMINOGEN
(Homo
sapiens) 		3 / 3 ARG A 776
THR A 678
VAL A 674
 None
 0.86A 2qakA-1qrzA:
0.0		 2qakA-1qrzA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 1qrz PLASMINOGEN
(Homo
sapiens) 		5 / 10 LEU A 599
ALA A 665
VAL A 746
VAL A 758
LEU A 755
 None
 1.28A 3ogpB-1qrzA:
undetectable		 3ogpB-1qrzA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1qrz PLASMINOGEN
(Homo
sapiens) 		4 / 6 TYR A 614
VAL A 630
VAL A 577
ILE A 633
 None
 1.08A 3pyyA-1qrzA:
undetectable		 3pyyA-1qrzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1qrz PLASMINOGEN
(Homo
sapiens) 		4 / 4 GLY A 590
GLY A 743
THR A 683
LEU A 697
 None
 0.93A 3si7C-1qrzA:
undetectable
3si7D-1qrzA:
undetectable		 3si7C-1qrzA:
21.92
3si7D-1qrzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1qrz PLASMINOGEN
(Homo
sapiens) 		5 / 10 VAL A 777
VAL A 775
TRP A 783
LEU A 788
LEU A 649
 None
 1.45A 4jtqA-1qrzA:
undetectable		 4jtqA-1qrzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1qrz PLASMINOGEN
(Homo
sapiens) 		4 / 8 LEU A 649
VAL A 787
LEU A 755
LEU A 667
 None
 0.93A 4l1xA-1qrzA:
undetectable		 4l1xA-1qrzA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 1qrz PLASMINOGEN
(Homo
sapiens) 		5 / 10 ILE A 593
LEU A 649
LEU A 605
ALA A 602
GLU A 724
 None
 1.20A 5y7pG-1qrzA:
0.0		 5y7pG-1qrzA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 1qrz PLASMINOGEN
(Homo
sapiens) 		5 / 7 GLY A 739
GLY A 743
PRO A 744
GLY A 590
GLY A 589
 None
 1.06A 6ag0A-1qrzA:
undetectable		 6ag0A-1qrzA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 1qrz PLASMINOGEN
(Homo
sapiens) 		4 / 6 GLU A 699
LYS A 556
VAL A 553
PRO A 551
 None
 1.32A 6fgdA-1qrzA:
undetectable		 6fgdA-1qrzA:
19.58