SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qsa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 ARG A 261
ASN A 265
ARG A 558
ASN A 565
 None
 1.50A 1f9gA-1qsaA:
2.7		 1f9gA-1qsaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 PHE A 213
ALA A 156
GLU A 159
LEU A 155
 None
 0.90A 1hk2A-1qsaA:
undetectable		 1hk2A-1qsaA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		3 / 3 GLU A 577
TRP A 321
LYS A 605
 None
 1.37A 1qu2A-1qsaA:
undetectable		 1qu2A-1qsaA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 LEU A 246
GLN A 245
LEU A 254
PHE A 222
 None
SO4  A 706 (-3.3A)
None
None
 0.99A 1v55C-1qsaA:
0.0
1v55J-1qsaA:
undetectable		 1v55C-1qsaA:
17.26
1v55J-1qsaA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		3 / 3 THR A 501
PRO A 499
THR A 503
 GOL  A 906 (-2.8A)
SO4  A 709 (-3.8A)
None
 0.79A 209dC-1qsaA:
undetectable		 209dC-1qsaA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		5 / 12 LEU A 128
LEU A 142
LYS A 141
ASN A 107
ALA A 104
 None
 1.19A 2bm9C-1qsaA:
undetectable		 2bm9C-1qsaA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 LEU A 246
GLN A 245
LEU A 254
PHE A 222
 None
SO4  A 706 (-3.3A)
None
None
 1.03A 2dysC-1qsaA:
undetectable
2dysJ-1qsaA:
undetectable		 2dysC-1qsaA:
17.26
2dysJ-1qsaA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 LEU A 246
GLN A 245
LEU A 254
PHE A 222
 None
SO4  A 706 (-3.3A)
None
None
 0.98A 2dysP-1qsaA:
0.0
2dysW-1qsaA:
undetectable		 2dysP-1qsaA:
17.26
2dysW-1qsaA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 LEU A 246
GLN A 245
LEU A 254
PHE A 222
 None
SO4  A 706 (-3.3A)
None
None
 1.01A 2eijC-1qsaA:
0.0
2eijJ-1qsaA:
undetectable		 2eijC-1qsaA:
17.26
2eijJ-1qsaA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 LEU A 246
GLN A 245
LEU A 254
PHE A 222
 None
SO4  A 706 (-3.3A)
None
None
 1.00A 2eijP-1qsaA:
undetectable
2eijW-1qsaA:
undetectable		 2eijP-1qsaA:
17.26
2eijW-1qsaA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 LEU A 246
GLN A 245
LEU A 254
PHE A 222
 None
SO4  A 706 (-3.3A)
None
None
 0.96A 2eikC-1qsaA:
undetectable
2eikJ-1qsaA:
undetectable		 2eikC-1qsaA:
17.26
2eikJ-1qsaA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 8 LEU A 246
GLN A 245
LEU A 254
PHE A 222
 None
SO4  A 706 (-3.3A)
None
None
 0.98A 2eilP-1qsaA:
undetectable
2eilW-1qsaA:
undetectable		 2eilP-1qsaA:
17.26
2eilW-1qsaA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 LEU A 246
GLN A 245
LEU A 254
PHE A 222
 None
SO4  A 706 (-3.3A)
None
None
 0.91A 2eimC-1qsaA:
undetectable
2eimJ-1qsaA:
undetectable		 2eimC-1qsaA:
17.26
2eimJ-1qsaA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 LEU A 246
GLN A 245
LEU A 254
PHE A 222
 None
SO4  A 706 (-3.3A)
None
None
 1.00A 2einC-1qsaA:
0.2
2einJ-1qsaA:
undetectable		 2einC-1qsaA:
17.26
2einJ-1qsaA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 6 LEU A 246
GLN A 245
LEU A 254
PHE A 222
 None
SO4  A 706 (-3.3A)
None
None
 0.99A 2einP-1qsaA:
0.9
2einW-1qsaA:
undetectable		 2einP-1qsaA:
17.26
2einW-1qsaA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 SER A 282
ILE A 279
ASP A 256
TRP A 260
 None
 0.95A 2x45B-1qsaA:
undetectable		 2x45B-1qsaA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 SER A 282
ILE A 279
ASP A 256
TRP A 260
 None
 0.93A 2x45C-1qsaA:
undetectable		 2x45C-1qsaA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 VAL A 559
ASN A 544
GLY A 542
VAL A 537
 None
 0.95A 2y05A-1qsaA:
undetectable
2y05B-1qsaA:
undetectable		 2y05A-1qsaA:
18.93
2y05B-1qsaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 6 LEU A 246
GLN A 245
LEU A 254
PHE A 222
 None
SO4  A 706 (-3.3A)
None
None
 1.02A 2zxwP-1qsaA:
undetectable
2zxwW-1qsaA:
undetectable		 2zxwP-1qsaA:
17.26
2zxwW-1qsaA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 SER A 282
ILE A 279
ASP A 256
TRP A 260
 None
 1.04A 3bu1A-1qsaA:
undetectable		 3bu1A-1qsaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		3 / 3 MET A 385
VAL A 408
GLU A 403
 None
 0.69A 3c6gA-1qsaA:
0.0		 3c6gA-1qsaA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		5 / 12 SER A 578
ILE A 579
PRO A 580
PHE A 581
ILE A 546
 None
 1.22A 3clbB-1qsaA:
undetectable		 3clbB-1qsaA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		5 / 9 ILE A 191
ALA A 190
THR A 208
ALA A 205
THR A 214
 None
None
None
None
GOL  A 901 (-3.9A)
 1.21A 3mdtA-1qsaA:
undetectable		 3mdtA-1qsaA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		3 / 3 VAL A 588
SER A 549
LEU A 592
 None
 0.72A 3n8xA-1qsaA:
1.7		 3n8xA-1qsaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		3 / 3 GLU A  81
PHE A  78
GLN A  53
 None
 1.02A 3r55A-1qsaA:
undetectable		 3r55A-1qsaA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		3 / 3 SER A 492
GLY A 493
GLN A 496
 None
 0.60A 3v4tH-1qsaA:
undetectable		 3v4tH-1qsaA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 5 GLY A 493
VAL A 485
PRO A 483
TYR A 453
 None
 1.16A 4grkA-1qsaA:
undetectable		 4grkA-1qsaA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		5 / 11 ALA A 243
GLN A 245
ARG A 215
ALA A 210
VAL A 225
 None
SO4  A 706 (-3.3A)
None
SO4  A 706 (-3.2A)
None
 1.14A 4nqaA-1qsaA:
undetectable		 4nqaA-1qsaA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		5 / 12 ARG A 545
ALA A 572
ARG A 293
ILE A 579
VAL A 588
 GOL  A 904 (-3.3A)
GOL  A 902 (-3.5A)
None
None
None
 1.05A 4uw0A-1qsaA:
undetectable		 4uw0A-1qsaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 ILE A 570
TRP A 324
LEU A 308
LEU A 304
 None
 0.97A 4xo7A-1qsaA:
undetectable		 4xo7A-1qsaA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		3 / 3 TRP A 307
ARG A 310
LEU A 287
 None
 0.85A 5dbyA-1qsaA:
0.3		 5dbyA-1qsaA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		5 / 12 ILE A 570
VAL A 576
ALA A 551
ALA A 550
GLY A 557
 None
 1.44A 5igpA-1qsaA:
undetectable		 5igpA-1qsaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		3 / 3 VAL A 588
GLU A 320
GLU A 577
 None
 0.75A 5jsdB-1qsaA:
undetectable
5jsdC-1qsaA:
undetectable		 5jsdB-1qsaA:
21.66
5jsdC-1qsaA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 6 PRO A 499
GLY A 500
THR A 501
LYS A 507
 SO4  A 709 (-3.8A)
SO4  A 709 (-3.4A)
GOL  A 906 (-2.8A)
None
 0.69A 5xxiA-1qsaA:
0.0		 5xxiA-1qsaA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)
(Escherichia
coli) 		4 / 7 VAL A 588
ILE A 474
MET A 498
GLY A 500
 None
None
SO4  A 709 ( 4.5A)
SO4  A 709 (-3.4A)
 0.83A 6hd6B-1qsaA:
undetectable		 6hd6B-1qsaA:
9.40