SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 ALA A 414
THR A 569
THR A 568
ILE A 416
GLY A 532
 None
 1.13A 1c9sN-1qu2A:
0.0
1c9sO-1qu2A:
0.0		 1c9sN-1qu2A:
7.28
1c9sO-1qu2A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 ALA A 414
THR A 569
THR A 568
ILE A 416
GLY A 532
 None
 1.12A 1c9sP-1qu2A:
0.0
1c9sQ-1qu2A:
0.0		 1c9sP-1qu2A:
7.28
1c9sQ-1qu2A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 ALA A 414
THR A 569
THR A 568
ILE A 416
GLY A 532
 None
 1.13A 1c9sQ-1qu2A:
0.0
1c9sR-1qu2A:
0.0		 1c9sQ-1qu2A:
7.28
1c9sR-1qu2A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 GLY A 532
ALA A 414
THR A 569
THR A 568
ILE A 416
 None
 1.13A 1c9sL-1qu2A:
0.0
1c9sV-1qu2A:
0.0		 1c9sL-1qu2A:
7.28
1c9sV-1qu2A:
7.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 12 HIS A  67
GLY A  66
GLY A 555
ASP A 557
GLN A 558
HIS A 585
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
 1.13A 1ffyA-1qu2A:
62.3		 1ffyA-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 12 HIS A  67
SER A 565
GLY A 555
ASP A 557
GLN A 558
HIS A 585
 MRC  A1993 (-4.1A)
None
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
 1.25A 1ffyA-1qu2A:
62.3		 1ffyA-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 12 HIS A  67
SER A 566
GLY A 555
ASP A 557
GLN A 558
HIS A 585
 MRC  A1993 (-4.1A)
None
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
 1.27A 1ffyA-1qu2A:
62.3		 1ffyA-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		12 / 12 PRO A  56
HIS A  64
GLY A  66
ASN A  70
SER A 531
GLY A 555
ASP A 557
GLN A 558
HIS A 585
PHE A 587
VAL A 588
MET A 596
 MRC  A1993 (-3.4A)
MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 ( 4.2A)
MRC  A1993 ( 4.0A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
MRC  A1993 (-3.5A)
MRC  A1993 (-3.9A)
None
 0.07A 1ffyA-1qu2A:
62.3		 1ffyA-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 12 PRO A  57
GLY A 555
ASP A 557
GLN A 558
HIS A 585
PHE A 587
 MRC  A1993 ( 4.7A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
MRC  A1993 (-3.5A)
 1.29A 1ffyA-1qu2A:
62.3		 1ffyA-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FFY_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 6 PRO A  57
HIS A  67
TRP A 528
GLU A 554
TRP A 562
LYS A 598
 MRC  A1993 ( 4.7A)
MRC  A1993 (-4.1A)
None
MRC  A1993 (-3.2A)
MRC  A1993 (-4.8A)
None
 0.05A 1ffyA-1qu2A:
62.3		 1ffyA-1qu2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 GLY A 532
ALA A 414
THR A 569
THR A 568
ILE A 416
 None
 1.12A 1gtfD-1qu2A:
0.0
1gtfE-1qu2A:
0.0		 1gtfD-1qu2A:
7.28
1gtfE-1qu2A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 GLY A 532
ALA A 414
THR A 569
THR A 568
ILE A 416
 None
 1.12A 1gtfJ-1qu2A:
0.0
1gtfK-1qu2A:
0.0		 1gtfJ-1qu2A:
7.28
1gtfK-1qu2A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 ALA A 414
THR A 569
THR A 568
ILE A 416
GLY A 532
 None
 1.14A 1gtfR-1qu2A:
0.0
1gtfS-1qu2A:
0.0		 1gtfR-1qu2A:
7.28
1gtfS-1qu2A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 ALA A 414
THR A 569
THR A 568
ILE A 416
GLY A 532
 None
 1.13A 1gtfS-1qu2A:
0.0
1gtfT-1qu2A:
0.0		 1gtfS-1qu2A:
7.28
1gtfT-1qu2A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 ALA A 414
THR A 569
THR A 568
ILE A 416
GLY A 532
 None
 1.14A 1gtnT-1qu2A:
0.0
1gtnU-1qu2A:
undetectable		 1gtnT-1qu2A:
7.28
1gtnU-1qu2A:
7.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		9 / 11 GLY A  55
PRO A  56
HIS A  64
HIS A  67
SER A 531
GLU A 554
GLY A 555
ASP A 557
GLN A 558
 MRC  A1993 ( 4.1A)
MRC  A1993 (-3.4A)
MRC  A1993 (-4.1A)
MRC  A1993 (-4.1A)
MRC  A1993 ( 4.0A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
 0.60A 1jzsA-1qu2A:
32.5		 1jzsA-1qu2A:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 SER A 565
GLU A 554
GLY A 555
ASP A 557
GLN A 558
 None
MRC  A1993 (-3.2A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
 1.14A 1jzsA-1qu2A:
32.5		 1jzsA-1qu2A:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 SER A 566
GLU A 554
GLY A 555
ASP A 557
GLN A 558
 None
MRC  A1993 (-3.2A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
 1.21A 1jzsA-1qu2A:
32.5		 1jzsA-1qu2A:
30.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 PHE A 688
ILE A 704
VAL A 767
LEU A 756
ILE A 712
 None
 1.32A 1kqwA-1qu2A:
undetectable		 1kqwA-1qu2A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A 545
GLU A 544
ALA A  40
TYR A  37
ARG A 542
 None
 1.20A 1l5rA-1qu2A:
1.3		 1l5rA-1qu2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 11 GLY A  66
HIS A  64
GLY A 555
ASP A 557
HIS A 585
VAL A 588
 MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-4.5A)
MRC  A1993 (-3.9A)
 1.33A 1pg2A-1qu2A:
22.5		 1pg2A-1qu2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 11 GLY A  66
HIS A  67
GLY A 555
ASP A 557
HIS A 585
VAL A 588
 MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-4.5A)
MRC  A1993 (-3.9A)
 0.72A 1pg2A-1qu2A:
22.5		 1pg2A-1qu2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 11 HIS A  64
GLY A  66
HIS A  67
ASP A 557
HIS A 585
VAL A 588
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.2A)
MRC  A1993 (-4.5A)
MRC  A1993 (-3.9A)
 0.90A 1pg2A-1qu2A:
22.5		 1pg2A-1qu2A:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 GLY A  66
HIS A  64
ASP A 557
GLN A 558
HIS A 585
 MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
 1.37A 1qu3A-1qu2A:
45.8		 1qu3A-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		11 / 12 HIS A  64
GLY A  66
HIS A  67
ASN A  70
SER A 531
GLU A 554
ASP A 557
GLN A 558
HIS A 585
PHE A 587
VAL A 588
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 ( 4.2A)
MRC  A1993 ( 4.0A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
MRC  A1993 (-3.5A)
MRC  A1993 (-3.9A)
 0.37A 1qu3A-1qu2A:
45.8		 1qu3A-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 HIS A  67
SER A 565
ASP A 557
GLN A 558
HIS A 585
 MRC  A1993 (-4.1A)
None
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
 1.43A 1qu3A-1qu2A:
45.8		 1qu3A-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 HIS A  67
SER A 566
ASP A 557
GLN A 558
HIS A 585
 MRC  A1993 (-4.1A)
None
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
 1.45A 1qu3A-1qu2A:
45.8		 1qu3A-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QU3_A_MRCA993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 4 TRP A 562
SER A 597
LYS A 598
VAL A 603
 MRC  A1993 (-4.8A)
MRC  A1993 (-4.5A)
None
None
 0.67A 1qu3A-1qu2A:
45.8		 1qu3A-1qu2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 LYS A 352
ILE A 405
THR A 400
 None
 0.78A 1rx3A-1qu2A:
undetectable		 1rx3A-1qu2A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 ALA A 414
THR A 569
THR A 568
ILE A 416
GLY A 532
 None
 1.12A 1utdH-1qu2A:
0.0
1utdI-1qu2A:
0.0		 1utdH-1qu2A:
7.28
1utdI-1qu2A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 ALA A 414
THR A 569
THR A 568
ILE A 416
GLY A 532
 None
 1.15A 1utdS-1qu2A:
undetectable
1utdT-1qu2A:
undetectable		 1utdS-1qu2A:
7.28
1utdT-1qu2A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 ALA A 414
THR A 569
THR A 568
ILE A 416
GLY A 532
 None
 1.13A 1utdU-1qu2A:
undetectable
1utdV-1qu2A:
0.0		 1utdU-1qu2A:
7.28
1utdV-1qu2A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HCJ_B_TACB888_1
(PROTEIN CHAIN
ELONGATION FACTOR
EF-TU)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 4 THR A 400
SER A 186
ASP A 397
PRO A 403
 None
 1.26A 2hcjA-1qu2A:
0.0
2hcjB-1qu2A:
2.5		 2hcjA-1qu2A:
5.45
2hcjB-1qu2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 THR A 400
SER A 186
ASP A 397
PRO A 403
 None
 1.25A 2hdnA-1qu2A:
0.0
2hdnB-1qu2A:
2.1
2hdnD-1qu2A:
2.4		 2hdnA-1qu2A:
5.45
2hdnB-1qu2A:
17.97
2hdnD-1qu2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 THR A 400
SER A 186
ASP A 397
PRO A 403
 None
 1.25A 2hdnB-1qu2A:
2.1
2hdnC-1qu2A:
0.0
2hdnD-1qu2A:
2.4		 2hdnB-1qu2A:
17.97
2hdnC-1qu2A:
5.45
2hdnD-1qu2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 THR A 400
SER A 186
ASP A 397
PRO A 403
 None
 1.24A 2hdnJ-1qu2A:
2.4
2hdnK-1qu2A:
undetectable
2hdnL-1qu2A:
1.8		 2hdnJ-1qu2A:
17.97
2hdnK-1qu2A:
5.45
2hdnL-1qu2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 PHE A 581
LEU A 583
LEU A 553
GLU A 697
 None
 1.08A 2jn3A-1qu2A:
undetectable		 2jn3A-1qu2A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 ILE A 748
MET A 741
GLN A 742
LEU A 728
 None
 0.91A 2qqcB-1qu2A:
undetectable
2qqcC-1qu2A:
0.0		 2qqcB-1qu2A:
9.08
2qqcC-1qu2A:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 LEU A 728
ILE A 748
MET A 741
GLN A 742
 None
 0.91A 2qqcA-1qu2A:
0.0
2qqcF-1qu2A:
undetectable		 2qqcA-1qu2A:
5.76
2qqcF-1qu2A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 LEU A 728
ILE A 748
MET A 741
GLN A 742
 None
 0.99A 2qqcG-1qu2A:
undetectable
2qqcJ-1qu2A:
undetectable		 2qqcG-1qu2A:
5.76
2qqcJ-1qu2A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 LEU A 728
ILE A 748
MET A 741
GLN A 742
 None
 0.95A 2qqcI-1qu2A:
undetectable
2qqcL-1qu2A:
undetectable		 2qqcI-1qu2A:
5.76
2qqcL-1qu2A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 ALA A 870
GLY A 874
ASP A 875
ASP A 866
 None
 0.69A 2uyqA-1qu2A:
undetectable		 2uyqA-1qu2A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 SER A 533
HIS A  53
HIS A 535
TYR A 159
 None
 1.41A 2vmyA-1qu2A:
undetectable
2vmyB-1qu2A:
undetectable		 2vmyA-1qu2A:
18.32
2vmyB-1qu2A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 GLY A  66
HIS A  67
GLY A 555
ASP A 557
HIS A 585
 MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-4.5A)
 0.44A 2x1lA-1qu2A:
22.7		 2x1lA-1qu2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 HIS A  64
GLY A  66
HIS A  67
ASP A 557
HIS A 585
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.2A)
MRC  A1993 (-4.5A)
 0.69A 2x1lA-1qu2A:
22.7		 2x1lA-1qu2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 12 HIS A  64
GLY A  66
HIS A  67
GLY A 555
ASP A 557
HIS A 585
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-4.5A)
 0.69A 2x1lB-1qu2A:
24.2		 2x1lB-1qu2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 11 HIS A  64
GLY A  66
HIS A  67
GLY A 555
ASP A 557
HIS A 585
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-4.5A)
 0.65A 2x1lC-1qu2A:
24.0		 2x1lC-1qu2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 SER A 856
GLU A 887
ASP A   2
 None
 0.65A 2zulA-1qu2A:
undetectable		 2zulA-1qu2A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 SER A 856
GLU A 887
ASP A   2
 None
 0.63A 3dmhA-1qu2A:
undetectable		 3dmhA-1qu2A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 LEU A 193
GLU A 197
SER A 186
THR A 400
 None
 1.38A 3dzgB-1qu2A:
undetectable		 3dzgB-1qu2A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 GLN A 558
HIS A  67
HIS A  64
ASP A 557
 MRC  A1993 (-3.5A)
MRC  A1993 (-4.1A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.2A)
 1.13A 3nvcA-1qu2A:
undetectable		 3nvcA-1qu2A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 LEU A  52
ASP A 550
ALA A 549
TYR A 552
 None
 1.18A 3rodD-1qu2A:
undetectable		 3rodD-1qu2A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 8 ALA A 811
VAL A 808
ASP A 807
LEU A 804
 None
 0.84A 3roxA-1qu2A:
undetectable		 3roxA-1qu2A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 8 PRO A  89
HIS A  53
ILE A  51
SER A 546
 None
 0.85A 3sfeB-1qu2A:
undetectable
3sfeC-1qu2A:
undetectable		 3sfeB-1qu2A:
14.90
3sfeC-1qu2A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 GLN A  84
TYR A  80
PRO A 758
LEU A 755
 None
 1.21A 3tgvD-1qu2A:
undetectable		 3tgvD-1qu2A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 THR A 233
TRP A 235
HIS A 392
TYR A 394
 None
 1.25A 4a3uA-1qu2A:
undetectable		 4a3uA-1qu2A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 LYS A 352
ILE A 405
THR A 400
 None
 0.76A 4gh8A-1qu2A:
undetectable		 4gh8A-1qu2A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 ASP A  95
ARG A 455
THR A 154
 MRC  A1993 ( 4.7A)
None
None
 0.85A 4i13A-1qu2A:
undetectable		 4i13A-1qu2A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 GLU A 707
ARG A 684
LEU A 685
ILE A 748
LEU A 721
 None
None
None
None
A  T  35 ( 4.6A)
 1.28A 4k36A-1qu2A:
undetectable		 4k36A-1qu2A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 GLU A 707
ARG A 684
LEU A 685
ILE A 748
LEU A 721
 None
None
None
None
A  T  35 ( 4.6A)
 1.26A 4k38B-1qu2A:
0.0		 4k38B-1qu2A:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 GLU A 707
ARG A 684
LEU A 685
ILE A 748
LEU A 721
 None
None
None
None
A  T  35 ( 4.6A)
 1.21A 4k39A-1qu2A:
undetectable		 4k39A-1qu2A:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 GLU A 294
TRP A 295
LYS A 291
 None
 1.24A 4k7aA-1qu2A:
1.5		 4k7aA-1qu2A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 GLY A 614
GLY A  19
ALA A 615
LEU A  20
GLN A  26
 None
 1.19A 4l8fD-1qu2A:
undetectable		 4l8fD-1qu2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A 755
LEU A 756
LEU A 760
ALA A 764
LEU A 749
 None
 1.15A 4ltwA-1qu2A:
undetectable		 4ltwA-1qu2A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 ASP A  95
ARG A 455
THR A 154
 MRC  A1993 ( 4.7A)
None
None
 0.84A 4p3rA-1qu2A:
undetectable		 4p3rA-1qu2A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 THR A 641
HIS A  67
LEU A 142
 None
MRC  A1993 (-4.1A)
None
 0.85A 5axdC-1qu2A:
undetectable		 5axdC-1qu2A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 PHE A 148
HIS A  67
LEU A 142
PRO A  92
 None
MRC  A1993 (-4.1A)
None
None
 1.49A 5csyB-1qu2A:
undetectable		 5csyB-1qu2A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 TRP A 436
ARG A 440
LEU A 582
 U  T   5 ( 3.8A)
C  T  70 ( 3.1A)
None
 0.98A 5dbyA-1qu2A:
0.3		 5dbyA-1qu2A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 HIS A  64
GLY A  66
VAL A 527
GLY A 555
ASP A 557
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
None
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
 1.17A 5hg0A-1qu2A:
4.3		 5hg0A-1qu2A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 12 HIS A  64
GLY A  66
HIS A  67
VAL A 527
GLY A 555
ASP A 557
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
None
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
 1.30A 5hg0B-1qu2A:
4.4		 5hg0B-1qu2A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 THR A 154
ASP A  95
ASP A 530
GLY A  98
 None
MRC  A1993 ( 4.7A)
None
None
 1.08A 5hwaA-1qu2A:
undetectable		 5hwaA-1qu2A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 LYS A 611
GLN A 135
ASN A  62
 None
 1.03A 5l2tA-1qu2A:
undetectable		 5l2tA-1qu2A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 8 LEU A 760
ILE A 648
ILE A 712
SER A 691
 None
 0.72A 5numA-1qu2A:
undetectable		 5numA-1qu2A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 LEU A 129
TRP A 459
GLU A 160
SER A 492
 None
 1.23A 5umwA-1qu2A:
undetectable
5umwF-1qu2A:
0.0		 5umwA-1qu2A:
6.71
5umwF-1qu2A:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 PHE A 355
ASP A 350
LYS A 352
 None
 0.84A 6awtD-1qu2A:
undetectable		 6awtD-1qu2A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 LEU A 620
THR A 692
ASN A 695
 None
 0.71A 6baaE-1qu2A:
0.2		 6baaE-1qu2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 LEU A 620
THR A 692
ASN A 695
 None
 0.71A 6baaF-1qu2A:
undetectable		 6baaF-1qu2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 LEU A 620
THR A 692
ASN A 695
 None
 0.71A 6baaG-1qu2A:
undetectable		 6baaG-1qu2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 LEU A 620
THR A 692
ASN A 695
 None
 0.71A 6baaH-1qu2A:
0.2		 6baaH-1qu2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 9 VAL A 271
LEU A 249
VAL A 315
ASP A 318
 None
None
A  T  73 ( 4.4A)
None
 0.99A 6c2mD-1qu2A:
undetectable		 6c2mD-1qu2A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 GLY A 329
ASP A 334
ILE A 336
 None
 0.54A 6dgxB-1qu2A:
undetectable		 6dgxB-1qu2A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 ASN A 311
VAL A 309
VAL A 241
THR A 326
 None
 1.16A 6f32B-1qu2A:
undetectable		 6f32B-1qu2A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 LEU A 620
ASP A 644
GLN A 640
GLN A 706
 None
C  T  25 ( 4.3A)
C  T  11 ( 2.6A)
U  T  12 ( 3.5A)
 1.37A 6g31D-1qu2A:
undetectable		 6g31D-1qu2A:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 LEU A 620
ASP A 644
GLN A 640
GLN A 706
 None
C  T  25 ( 4.3A)
C  T  11 ( 2.6A)
U  T  12 ( 3.5A)
 1.36A 6g31J-1qu2A:
undetectable		 6g31J-1qu2A:
5.66