SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qu4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		3 / 3 ASN A 319
PHE A 326
VAL A 288
 None
 0.66A 1kijA-1qu4A:
undetectable		 1kijA-1qu4A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		4 / 7 ILE A 108
PHE A  65
ALA A 111
ILE A 231
 None
None
PLP  A 600 ( 4.7A)
None
 0.89A 1oniB-1qu4A:
1.4
1oniC-1qu4A:
1.3		 1oniB-1qu4A:
16.46
1oniC-1qu4A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		4 / 8 ALA A 388
TYR A 389
GLY A 240
GLY A 237
 None
PLP  A 600 (-4.7A)
None
PLP  A 600 (-3.3A)
 0.84A 1rukH-1qu4A:
undetectable
1rukL-1qu4A:
undetectable		 1rukH-1qu4A:
18.22
1rukL-1qu4A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		4 / 6 ILE A 366
MET A 386
THR A 285
LEU A 286
 None
 0.99A 3ag1N-1qu4A:
undetectable
3ag1W-1qu4A:
undetectable		 3ag1N-1qu4A:
22.14
3ag1W-1qu4A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		3 / 3 PRO A 338
LEU A 381
ARG A 342
 None
 0.84A 3aqiA-1qu4A:
undetectable		 3aqiA-1qu4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		3 / 3 PRO A 338
LEU A 381
ARG A 342
 None
 0.80A 3aqiB-1qu4A:
undetectable		 3aqiB-1qu4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAM_A_LLLA500_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		5 / 12 ASP A  38
ASN A 319
SER A 325
ASP A 320
TYR A 406
 None
 1.50A 3hamA-1qu4A:
0.0		 3hamA-1qu4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		5 / 12 GLY A 236
GLY A 235
VAL A 280
ASP A  88
LEU A  77
 PLP  A 600 (-3.5A)
None
None
PLP  A 600 (-4.4A)
None
 1.09A 3m6vA-1qu4A:
undetectable		 3m6vA-1qu4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		5 / 10 LYS A  69
HIS A 197
GLY A 199
ARG A 277
TYR A 389
 PLP  A 600 (-1.5A)
PLP  A 600 (-4.2A)
None
PLP  A 600 (-4.5A)
PLP  A 600 (-4.7A)
 0.89A 3n2oC-1qu4A:
11.7
3n2oD-1qu4A:
24.5		 3n2oC-1qu4A:
22.86
3n2oD-1qu4A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		4 / 7 ILE A 212
PHE A 219
MET A 229
GLY A 193
 None
 1.06A 3sj0X-1qu4A:
undetectable		 3sj0X-1qu4A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		4 / 5 GLY A 321
VAL A 322
ASP A 364
THR A 359
 None
 1.25A 3vqrB-1qu4A:
undetectable		 3vqrB-1qu4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		4 / 7 ILE A 212
PHE A 219
MET A 229
GLY A 193
 None
 1.06A 4hbfA-1qu4A:
undetectable		 4hbfA-1qu4A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		4 / 8 GLY A 324
ASN A 327
MET A 386
ILE A 366
 None
 0.98A 4j4vC-1qu4A:
undetectable		 4j4vC-1qu4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		5 / 10 THR A 207
ALA A 211
SER A 215
GLY A 199
ASP A 233
 None
 1.31A 5l66K-1qu4A:
undetectable
5l66L-1qu4A:
undetectable		 5l66K-1qu4A:
20.34
5l66L-1qu4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		5 / 10 THR A 207
ALA A 211
SER A 215
GLY A 199
ASP A 233
 None
 1.32A 5l66Y-1qu4A:
undetectable
5l66Z-1qu4A:
undetectable		 5l66Y-1qu4A:
20.34
5l66Z-1qu4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		4 / 6 ARG A 242
ALA A 244
PRO A 239
GLU A 249
 None
 1.10A 5odqA-1qu4A:
2.3		 5odqA-1qu4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1qu4 ORNITHINE
DECARBOXYLASE
(Trypanosoma
brucei) 		5 / 12 PRO A  64
GLY A  86
LYS A 107
ILE A 234
GLY A 193
 None
 1.26A 5wwsB-1qu4A:
undetectable		 5wwsB-1qu4A:
25.40