SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qua'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 5 SER A  54
ASN A  92
ALA A  95
ASP A  93
None
1.45A 1lqtA-1quaA:
3.9
1lqtB-1quaA:
3.7
1lqtA-1quaA:
17.18
1lqtB-1quaA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 5 SER A  54
ASN A  92
ALA A  95
ASP A  93
None
1.44A 1lquA-1quaA:
3.9
1lquB-1quaA:
3.4
1lquA-1quaA:
17.18
1lquB-1quaA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.13A 1os2A-1quaA:
10.9
1os2A-1quaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.11A 1os2D-1quaA:
11.0
1os2D-1quaA:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R55_A_097A518_1
(ADAM 33)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
7 / 10 THR A 107
VAL A 108
THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
None
None
None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.42A 1r55A-1quaA:
30.2
1r55A-1quaA:
34.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.19A 1uttA-1quaA:
11.3
1uttA-1quaA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.16A 1utzA-1quaA:
11.1
1utzA-1quaA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.19A 1utzB-1quaA:
11.2
1utzB-1quaA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 6 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.11A 1y93A-1quaA:
11.3
1y93A-1quaA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.10A 2hu6A-1quaA:
11.3
2hu6A-1quaA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
5 / 9 LEU A 168
THR A 139
HIS A 142
HIS A 146
HIS A 152
None
None
ZN  A 999 (-3.2A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
1.38A 2jihA-1quaA:
25.8
2jihA-1quaA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
6 / 9 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 168
None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
None
0.79A 2jihA-1quaA:
25.8
2jihA-1quaA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
5 / 8 HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 168
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
None
0.43A 2jihB-1quaA:
25.8
2jihB-1quaA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
5 / 8 LEU A 168
THR A 139
HIS A 142
HIS A 146
HIS A 152
None
None
ZN  A 999 (-3.2A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
1.28A 2jihB-1quaA:
25.8
2jihB-1quaA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
5 / 8 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.36A 2jihB-1quaA:
25.8
2jihB-1quaA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
5 / 12 SER A  71
GLY A 124
ALA A 111
LEU A 144
LEU A  12
None
0.99A 2nyuA-1quaA:
undetectable
2nyuA-1quaA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
5 / 12 LEU A 144
ASN A  94
ALA A  95
MET A  40
LEU A  53
None
1.46A 2oaxC-1quaA:
undetectable
2oaxC-1quaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 6 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.19A 2ow9A-1quaA:
10.9
2ow9A-1quaA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.19A 2ow9B-1quaA:
10.8
2ow9B-1quaA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.22A 2ozrC-1quaA:
10.6
2ozrC-1quaA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.25A 2ozrD-1quaA:
10.6
2ozrD-1quaA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.35A 2ozrE-1quaA:
10.7
2ozrE-1quaA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
3 / 3 HIS A 142
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.30A 2ozrF-1quaA:
10.6
2ozrF-1quaA:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
5 / 9 HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 168
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
None
0.67A 3hy7A-1quaA:
26.5
3hy7A-1quaA:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
5 / 9 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.29A 3hy7A-1quaA:
26.5
3hy7A-1quaA:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
6 / 9 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 168
None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
None
0.60A 3hy7B-1quaA:
26.5
3hy7B-1quaA:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.19A 3kecA-1quaA:
10.9
3kecA-1quaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
3 / 3 HIS A 142
GLU A 143
HIS A 146
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
0.12A 3kecB-1quaA:
10.7
3kecB-1quaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.11A 3likA-1quaA:
11.2
3likA-1quaA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.13A 3lilA-1quaA:
11.3
3lilA-1quaA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.13A 3ljgA-1quaA:
11.4
3ljgA-1quaA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.10A 3lkaA-1quaA:
11.3
3lkaA-1quaA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
5 / 12 LEU A 144
ASN A  94
ALA A  95
MET A  40
LEU A  53
None
1.44A 3vhuA-1quaA:
undetectable
3vhuA-1quaA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 6 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.27A 4a7bA-1quaA:
10.6
4a7bA-1quaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 4 LEU A 168
ILE A 163
HIS A 142
VAL A 138
None
None
ZN  A 999 (-3.2A)
None
1.27A 4xyzA-1quaA:
undetectable
4xyzA-1quaA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 7 LEU A 197
THR A   6
PRO A 193
LEU A  47
None
0.98A 5fxtA-1quaA:
undetectable
5fxtA-1quaA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.13A 5n5jA-1quaA:
11.4
5n5jA-1quaA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
0.12A 5n5kA-1quaA:
11.4
5n5kA-1quaA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)
1qua ACUTOLYSIN-C
(Deinagkistrodon
acutus)
4 / 8 LYS A  76
ALA A  79
SER A  71
GLY A 124
None
1.00A 5v0vA-1quaA:
undetectable
5v0vA-1quaA:
14.73