SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1quu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DF7_A_MTXA501_2 (DIHYDROFOLATE REDUCTASE)	1quu	HUMAN SKELETAL MUSCLE ALPHA-ACTININ 2 (Homo sapiens)	3 / 3	TRP A 29 ARG A 20 THR A 28	None	0.87A	1df7A-1quuA: undetectable	1df7A-1quuA: 18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K6C_B_MK1B902_2 (POL POLYPROTEIN)	1quu	HUMAN SKELETAL MUSCLE ALPHA-ACTININ 2 (Homo sapiens)	5 / 12	GLY A 147 ALA A 148 ASP A 151 VAL A 231 VAL A 227	None	0.95A	1k6cB-1quuA: undetectable	1k6cB-1quuA: 14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AZX_A_TRPA602_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	1quu	HUMAN SKELETAL MUSCLE ALPHA-ACTININ 2 (Homo sapiens)	4 / 8	PHE A 156 LEU A 167 ILE A 168 HIS A 171	None	0.88A	2azxA-1quuA: undetectable	2azxA-1quuA: 18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2X_A_TMQA202_2 (DIHYDROFOLATE REDUCTASE)	1quu	HUMAN SKELETAL MUSCLE ALPHA-ACTININ 2 (Homo sapiens)	3 / 3	TRP A 29 GLN A 21 THR A 28	None	1.00A	4m2xA-1quuA: undetectable	4m2xA-1quuA: 19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NKN_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	1quu	HUMAN SKELETAL MUSCLE ALPHA-ACTININ 2 (Homo sapiens)	3 / 3	ARG A 11 LEU A 15 PHE A 19	None	0.54A	6nknP-1quuA: 3.9	6nknP-1quuA: 18.05

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DF7_A_MTXA501_2","DIHYDROFOLATE REDUCTASE","1quu","HUMAN SKELETAL MUSCLE ALPHA-ACTININ 2","Homo sapiens",3,"TRP A  29;ARG A  20;THR A  28","None","0.87A","1df7A-1quuA:undetectable","1df7A-1quuA:18.92"],["1K6C_B_MK1B902_2","POL POLYPROTEIN","1quu","HUMAN SKELETAL MUSCLE ALPHA-ACTININ 2","Homo sapiens",5,"GLY A 147;ALA A 148;ASP A 151;VAL A 231;VAL A 227","None","0.95A","1k6cB-1quuA:undetectable","1k6cB-1quuA:14.46"],["2AZX_A_TRPA602_0","TRYPTOPHANYL-TRNA SYNTHETASE","1quu","HUMAN SKELETAL MUSCLE ALPHA-ACTININ 2","Homo sapiens",4,"PHE A 156;LEU A 167;ILE A 168;HIS A 171","None","0.88A","2azxA-1quuA:undetectable","2azxA-1quuA:18.93"],["4M2X_A_TMQA202_2","DIHYDROFOLATE REDUCTASE","1quu","HUMAN SKELETAL MUSCLE ALPHA-ACTININ 2","Homo sapiens",3,"TRP A  29;GLN A  21;THR A  28","None","1.00A","4m2xA-1quuA:undetectable","4m2xA-1quuA:19.69"],["6NKN_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","1quu","HUMAN SKELETAL MUSCLE ALPHA-ACTININ 2","Homo sapiens",3,"ARG A  11;LEU A  15;PHE A  19","None","0.54A","6nknP-1quuA:3.9","6nknP-1quuA:18.05"]]