SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qvb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		4 / 8 TYR A 288
TYR A 378
TYR A 264
HIS A 245
 None
 1.23A 2ha2A-1qvbA:
undetectable		 2ha2A-1qvbA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		4 / 8 TYR A 288
TYR A 378
TYR A 264
HIS A 245
 None
 1.23A 2ha2B-1qvbA:
undetectable		 2ha2B-1qvbA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		5 / 11 ASN A 207
GLU A 208
TYR A 321
GLU A 386
TRP A 424
 None
 0.81A 2v3dB-1qvbA:
15.2		 2v3dB-1qvbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XUD_A_DMEA1544_1
(ACETYLCHOLINESTERASE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		4 / 6 TYR A 288
TYR A 378
TYR A 264
HIS A 245
 None
 1.24A 2xudA-1qvbA:
0.7		 2xudA-1qvbA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		4 / 8 LYS A 283
ASN A 376
LYS A 372
PRO A 417
 None
 1.47A 3bjwD-1qvbA:
0.0		 3bjwD-1qvbA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		4 / 8 TYR A 150
ASN A 207
PHE A 440
TRP A 424
 None
 1.46A 3bjwD-1qvbA:
0.0		 3bjwD-1qvbA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		4 / 6 LEU A 374
TYR A 375
ARG A 377
LEU A 382
 None
 0.87A 3f33A-1qvbA:
undetectable		 3f33A-1qvbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		4 / 5 PRO A  28
SER A  25
LEU A 156
SER A  84
 None
 1.46A 3iluH-1qvbA:
undetectable		 3iluH-1qvbA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		4 / 6 LEU A 374
TYR A 375
ARG A 377
LEU A 382
 None
 0.97A 3ravA-1qvbA:
undetectable		 3ravA-1qvbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		5 / 9 ALA A 351
ARG A 323
GLY A 340
ASN A 353
SER A 349
 None
 1.11A 4a3uA-1qvbA:
12.8		 4a3uA-1qvbA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		4 / 6 LYS A 372
ILE A 416
VAL A 418
LEU A 382
 None
 1.10A 4em2A-1qvbA:
undetectable		 4em2A-1qvbA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		5 / 12 GLY A 441
ARG A 455
VAL A 408
TYR A 421
VAL A 384
 None
 1.42A 4ffwA-1qvbA:
undetectable		 4ffwA-1qvbA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		5 / 12 GLY A 441
VAL A 408
TYR A 421
ASN A 387
HIS A 404
 None
 1.45A 4ffwA-1qvbA:
undetectable		 4ffwA-1qvbA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		3 / 3 ASP A 235
LEU A 177
VAL A 182
 None
 0.70A 4jecB-1qvbA:
undetectable		 4jecB-1qvbA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		3 / 3 ARG A 397
HIS A 423
SER A 457
 None
 0.79A 4mjwA-1qvbA:
0.0
4mjwB-1qvbA:
0.0		 4mjwA-1qvbA:
21.37
4mjwB-1qvbA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		3 / 3 SER A 457
ARG A 397
HIS A 423
 None
 0.76A 4mjwA-1qvbA:
0.0
4mjwB-1qvbA:
0.0		 4mjwA-1qvbA:
21.37
4mjwB-1qvbA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		4 / 5 LEU A 313
ASP A 381
TRP A 315
ILE A 383
 None
 1.21A 4mwrA-1qvbA:
undetectable		 4mwrA-1qvbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		4 / 4 LYS A 195
ASN A 251
ASP A 110
ASP A 120
 None
 1.14A 4o1eB-1qvbA:
2.7		 4o1eB-1qvbA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		4 / 6 TYR A 378
LEU A 313
HIS A 245
THR A 205
 None
 1.35A 4paeA-1qvbA:
undetectable		 4paeA-1qvbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		5 / 12 GLY A 388
GLY A 441
ASP A 428
TYR A 430
TYR A 321
 None
 1.22A 4rtsA-1qvbA:
undetectable		 4rtsA-1qvbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		4 / 6 ARG A 397
ASP A 391
VAL A 445
ASP A 428
 None
 1.37A 4xqeB-1qvbA:
undetectable		 4xqeB-1qvbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		3 / 3 GLU A 214
LYS A 286
ASN A 210
 None
 1.00A 4y1dA-1qvbA:
0.0
4y1dD-1qvbA:
undetectable		 4y1dA-1qvbA:
17.05
4y1dD-1qvbA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		3 / 3 ASP A  31
ASN A  29
PHE A  87
 None
 0.79A 5dsgB-1qvbA:
undetectable		 5dsgB-1qvbA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		3 / 3 GLU A  82
TRP A  83
ASN A 148
 None
 0.75A 5dv4A-1qvbA:
undetectable		 5dv4A-1qvbA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		3 / 3 VAL A 111
GLU A 180
GLU A 184
 None
 0.79A 5jsdB-1qvbA:
0.0
5jsdC-1qvbA:
0.0		 5jsdB-1qvbA:
20.52
5jsdC-1qvbA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		3 / 3 SER A 322
TYR A 321
TYR A 320
 None
 0.76A 5lakA-1qvbA:
0.0
5lakI-1qvbA:
undetectable		 5lakA-1qvbA:
19.17
5lakI-1qvbA:
0.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		3 / 3 SER A 322
TYR A 321
TYR A 320
 None
 0.67A 5lakC-1qvbA:
0.0
5lakJ-1qvbA:
undetectable		 5lakC-1qvbA:
19.17
5lakJ-1qvbA:
0.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		5 / 12 PHE A 290
ILE A 242
PHE A 185
ALA A 186
ILE A 252
 None
 1.03A 5vceA-1qvbA:
0.0		 5vceA-1qvbA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		4 / 5 MET A 134
TYR A  58
GLY A  57
GLY A  21
 None
 1.12A 5x7pA-1qvbA:
1.2		 5x7pA-1qvbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		4 / 5 ILE A 263
THR A 385
THR A 205
LEU A 313
 None
 1.08A 6f3mD-1qvbA:
undetectable		 6f3mD-1qvbA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1qvb BETA-GLYCOSIDASE
(Thermosphaera
aggregans) 		5 / 10 SER A 356
GLY A 359
TRP A 360
GLY A 340
LEU A 313
 None
 1.39A 6hqbA-1qvbA:
undetectable
6hqbJ-1qvbA:
undetectable		 6hqbA-1qvbA:
11.04
6hqbJ-1qvbA:
6.08