SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qvz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A   8
GLY A 107
PHE A  27
VAL A 137
ALA A 136
 None
CSO  A 138 ( 3.5A)
None
CSO  A 138 ( 2.6A)
None
 1.05A 1axwA-1qvzA:
0.0		 1axwA-1qvzA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A   8
GLY A 107
PHE A  27
VAL A 137
ALA A 136
 None
CSO  A 138 ( 3.5A)
None
CSO  A 138 ( 2.6A)
None
 0.96A 1tlsA-1qvzA:
0.0		 1tlsA-1qvzA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A   8
GLY A 107
PHE A  27
VAL A 137
ALA A 136
 None
CSO  A 138 ( 3.5A)
None
CSO  A 138 ( 2.6A)
None
 1.05A 1tlsB-1qvzA:
0.0		 1tlsB-1qvzA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A   8
GLY A 107
PHE A  27
VAL A 137
ALA A 136
 None
CSO  A 138 ( 3.5A)
None
CSO  A 138 ( 2.6A)
None
 1.02A 1tsnA-1qvzA:
0.0		 1tsnA-1qvzA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 206
GLY A 169
PRO A 221
ALA A 222
 None
None
CSO  A 138 ( 4.9A)
None
 0.93A 2aofA-1qvzA:
undetectable		 2aofA-1qvzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 206
ASN A 220
GLY A 203
GLY A 164
VAL A 187
 None
None
None
CSO  A 138 ( 3.6A)
CSO  A 138 ( 4.9A)
 1.45A 2fqyA-1qvzA:
4.4		 2fqyA-1qvzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 156
GLY A 159
ALA A 196
ILE A 210
PRO A 141
ILE A 157
 None
None
None
None
CSO  A 138 ( 4.3A)
None
 1.39A 2ienA-1qvzA:
undetectable		 2ienA-1qvzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A   8
GLY A 107
PHE A  27
VAL A 137
ALA A 136
 None
CSO  A 138 ( 3.5A)
None
CSO  A 138 ( 2.6A)
None
 1.07A 2kceA-1qvzA:
undetectable		 2kceA-1qvzA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 PHE A  65
VAL A  29
TYR A  18
ASN A 220
 None
 1.25A 2wekA-1qvzA:
3.4		 2wekA-1qvzA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 156
GLY A 159
ALA A 196
ILE A 210
PRO A 141
ILE A 157
 None
None
None
None
CSO  A 138 ( 4.3A)
None
 1.39A 3lzuB-1qvzA:
undetectable		 3lzuB-1qvzA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 ALA A  96
ASP A  98
VAL A  48
VAL A 134
ILE A 127
 None
 1.23A 3oxxB-1qvzA:
undetectable		 3oxxB-1qvzA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 156
GLY A 159
ALA A 196
ILE A 210
PRO A 141
ILE A 157
 None
None
None
None
CSO  A 138 ( 4.3A)
None
 1.46A 3s54A-1qvzA:
undetectable		 3s54A-1qvzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 156
GLY A 159
ALA A 196
ILE A 210
PRO A 141
ILE A 157
 None
None
None
None
CSO  A 138 ( 4.3A)
None
 1.45A 3s54B-1qvzA:
undetectable		 3s54B-1qvzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 156
GLY A 159
ALA A 196
ILE A 210
PRO A 141
ILE A 157
 None
None
None
None
CSO  A 138 ( 4.3A)
None
 1.46A 3tkwB-1qvzA:
undetectable		 3tkwB-1qvzA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  50
ALA A   9
ALA A 142
GLY A 109
LEU A 111
 None
 0.94A 4oaeA-1qvzA:
undetectable		 4oaeA-1qvzA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 190
GLY A 146
PHE A 102
PHE A 144
GLY A 140
 None
None
None
None
CSO  A 138 ( 4.4A)
 1.32A 4pevB-1qvzA:
3.1		 4pevB-1qvzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 GLU A  30
VAL A  29
GLY A  25
THR A  11
 CSO  A 138 ( 3.1A)
None
None
None
 0.96A 5sxqA-1qvzA:
undetectable		 5sxqA-1qvzA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 GLU A  30
VAL A  29
GLY A  25
THR A  11
 CSO  A 138 ( 3.1A)
None
None
None
 0.94A 5sxtA-1qvzA:
undetectable		 5sxtA-1qvzA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 GLU A  30
VAL A  29
GLY A  25
THR A  11
 CSO  A 138 ( 3.1A)
None
None
None
 0.95A 5sxtB-1qvzA:
undetectable		 5sxtB-1qvzA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 GLU A  30
VAL A  29
GLY A  25
THR A  11
 CSO  A 138 ( 3.1A)
None
None
None
 0.99A 5syjB-1qvzA:
undetectable		 5syjB-1qvzA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 102
PRO A 141
MET A 143
VAL A 134
 None
CSO  A 138 ( 4.3A)
None
None
 0.83A 6ekzA-1qvzA:
undetectable		 6ekzA-1qvzA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 1qvz YDR533C PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 133
PHE A  43
ILE A 101
SER A 209
VAL A 229
 None
 1.33A 6gsdA-1qvzA:
5.6		 6gsdA-1qvzA:
16.74