SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qwj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		4 / 5 TYR A 235
VAL A 137
ILE A 159
MET A 238
 None
 1.46A 1opjA-1qwjA:
0.0		 1opjA-1qwjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		4 / 6 PHE A  83
VAL A  73
LEU A 147
ALA A  80
 None
 1.00A 2e1qA-1qwjA:
undetectable		 2e1qA-1qwjA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		4 / 6 PHE A  83
VAL A  73
LEU A 147
ALA A  80
 None
 1.00A 2e1qC-1qwjA:
0.0		 2e1qC-1qwjA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		4 / 8 ARG A 258
ASP A  79
GLY A 266
PHE A 265
 None
 0.88A 2tsrB-1qwjA:
undetectable		 2tsrB-1qwjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		4 / 8 PHE A  83
VAL A  73
LEU A 147
ALA A  80
 None
 0.93A 3ax7A-1qwjA:
undetectable		 3ax7A-1qwjA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		6 / 12 GLY A 103
ALA A 104
VAL A  47
GLY A  71
THR A  90
VAL A  88
 None
 1.23A 3el5B-1qwjA:
undetectable		 3el5B-1qwjA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		4 / 8 GLY A 103
PHE A 215
PHE A 217
PHE A  83
 None
 1.08A 3ko0D-1qwjA:
undetectable
3ko0E-1qwjA:
undetectable		 3ko0D-1qwjA:
15.95
3ko0E-1qwjA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		4 / 8 PHE A  83
GLY A 103
PHE A 215
PHE A 217
 None
 1.00A 3ko0B-1qwjA:
undetectable
3ko0J-1qwjA:
undetectable		 3ko0B-1qwjA:
15.95
3ko0J-1qwjA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		4 / 7 PHE A  83
GLY A 103
PHE A 215
PHE A 217
 None
 1.06A 3ko0K-1qwjA:
undetectable
3ko0S-1qwjA:
undetectable		 3ko0K-1qwjA:
15.95
3ko0S-1qwjA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		5 / 12 GLY A 231
GLY A 230
PRO A  41
VAL A  82
LEU A  43
 None
 1.01A 3m6wA-1qwjA:
undetectable		 3m6wA-1qwjA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		4 / 7 PHE A  83
VAL A  73
LEU A 147
ALA A  80
 None
 0.98A 3uniA-1qwjA:
0.8		 3uniA-1qwjA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		4 / 8 VAL A 155
ILE A 140
ALA A  76
LEU A 147
 None
 0.70A 4qrcA-1qwjA:
undetectable		 4qrcA-1qwjA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		4 / 7 ILE A  70
PRO A 145
ILE A 246
ASP A 245
 None
None
None
NCC  A2002 ( 4.9A)
 0.88A 4w5oA-1qwjA:
0.0		 4w5oA-1qwjA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		4 / 5 LEU A 121
ASP A 122
TYR A 227
LEU A 228
 None
 1.23A 4wozF-1qwjA:
1.9
4wozH-1qwjA:
2.2		 4wozF-1qwjA:
23.64
4wozH-1qwjA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		4 / 7 ILE A  70
PRO A 145
ILE A 246
ASP A 245
 None
None
None
NCC  A2002 ( 4.9A)
 0.86A 4z4eA-1qwjA:
0.0		 4z4eA-1qwjA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		4 / 7 ILE A  70
PRO A 145
ILE A 246
ASP A 245
 None
None
None
NCC  A2002 ( 4.9A)
 0.89A 4z4gA-1qwjA:
0.0		 4z4gA-1qwjA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		5 / 7 ILE A  95
LYS A  59
LEU A  58
GLY A  52
GLY A  51
 None
 0.94A 5a06A-1qwjA:
2.8		 5a06A-1qwjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		5 / 7 ILE A  95
LYS A  59
LEU A  58
GLY A  52
GLY A  51
 None
 0.97A 5a06B-1qwjA:
2.9		 5a06B-1qwjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		5 / 7 ILE A  95
LYS A  59
LEU A  58
GLY A  52
GLY A  51
 None
 0.95A 5a06C-1qwjA:
2.8		 5a06C-1qwjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		5 / 7 ILE A  95
LYS A  59
LEU A  58
GLY A  52
GLY A  51
 None
 0.93A 5a06E-1qwjA:
2.8		 5a06E-1qwjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		5 / 7 ILE A  95
LYS A  59
LEU A  58
GLY A  52
GLY A  51
 None
 0.95A 5a06F-1qwjA:
2.7		 5a06F-1qwjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE
(Mus
musculus) 		3 / 3 ASN A 139
LEU A 152
PHE A 168
 None
 0.71A 5dsgA-1qwjA:
undetectable		 5dsgA-1qwjA:
20.83