SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qwk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		5 / 12 PHE A 312
PHE A 138
SER A 174
ILE A 160
VAL A 134
 None
 1.21A 2ft9A-1qwkA:
undetectable		 2ft9A-1qwkA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		5 / 12 PRO A  17
ILE A  46
LEU A  21
ALA A  34
LEU A  65
 None
 1.15A 3a50A-1qwkA:
undetectable		 3a50A-1qwkA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		5 / 12 THR A  23
LEU A  21
ILE A  78
VAL A  71
LEU A  65
 None
 1.25A 3a51B-1qwkA:
0.0		 3a51B-1qwkA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 8 HIS A 187
LEU A  45
LEU A 261
SER A 174
 None
 1.01A 3lm8B-1qwkA:
undetectable
3lm8D-1qwkA:
undetectable		 3lm8B-1qwkA:
21.54
3lm8D-1qwkA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 6 TRP A 135
PHE A 138
GLU A 132
VAL A 131
 None
 1.46A 3n5pA-1qwkA:
0.0
3n5pB-1qwkA:
0.0		 3n5pA-1qwkA:
22.27
3n5pB-1qwkA:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		5 / 12 TYR A  52
HIS A 114
ASN A 154
TYR A 201
PHE A 299
 None
 0.72A 3r43A-1qwkA:
40.4		 3r43A-1qwkA:
39.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		5 / 12 TYR A  52
TRP A  83
HIS A 114
ASN A 154
TYR A 201
 None
 0.29A 3r43A-1qwkA:
40.4		 3r43A-1qwkA:
39.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		5 / 10 TYR A  52
HIS A 114
ASN A 154
TYR A 201
PHE A 299
 None
 0.55A 3r58A-1qwkA:
40.4		 3r58A-1qwkA:
39.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		6 / 12 TYR A  52
TRP A  83
HIS A 114
ASN A 154
TYR A 201
PHE A 299
 None
 0.61A 3r6iA-1qwkA:
40.3		 3r6iA-1qwkA:
39.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R7M_A_SUZA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		5 / 10 TYR A  52
TRP A  83
HIS A 114
ASN A 154
PHE A 299
 None
 0.80A 3r7mA-1qwkA:
40.3		 3r7mA-1qwkA:
39.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		5 / 9 TYR A  52
HIS A 114
ASN A 154
TYR A 201
PHE A 299
 None
 0.72A 3r8gA-1qwkA:
40.3		 3r8gA-1qwkA:
39.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		5 / 12 TYR A  52
HIS A 114
ASN A 154
TYR A 201
PHE A 299
 None
 0.68A 3r94A-1qwkA:
40.2		 3r94A-1qwkA:
39.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		5 / 12 TYR A  52
TRP A  83
HIS A 114
ASN A 154
TYR A 201
 None
 0.29A 3ug8A-1qwkA:
40.3		 3ug8A-1qwkA:
39.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 7 TYR A  52
ASN A 154
GLU A 177
GLN A  25
 None
 1.07A 3ugrA-1qwkA:
39.9		 3ugrA-1qwkA:
39.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 8 THR A  48
LEU A 105
LEU A 103
GLY A  59
 None
 0.87A 4c9nA-1qwkA:
undetectable		 4c9nA-1qwkA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 8 VAL A  51
TYR A  52
TRP A  83
HIS A 114
 None
 0.45A 4jq1B-1qwkA:
40.9		 4jq1B-1qwkA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 8 VAL A  51
TYR A  52
TRP A  83
HIS A 114
 None
 0.24A 4jtrA-1qwkA:
41.2		 4jtrA-1qwkA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 6 VAL A  51
TYR A  52
TRP A  83
HIS A 114
 None
 0.24A 4jtrB-1qwkA:
41.1		 4jtrB-1qwkA:
39.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 8 LEU A  65
LEU A  66
ASP A 109
ILE A  78
 None
 0.90A 4lzrA-1qwkA:
undetectable		 4lzrA-1qwkA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		5 / 10 PRO A  17
VAL A  18
ALA A 259
GLY A  42
GLY A  20
 None
 1.28A 4mmdA-1qwkA:
undetectable		 4mmdA-1qwkA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPT_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 6 VAL A 131
TRP A 135
PHE A 138
GLU A 132
 None
 1.46A 4uptA-1qwkA:
0.0
4uptB-1qwkA:
0.0		 4uptA-1qwkA:
22.32
4uptB-1qwkA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		6 / 9 TYR A  52
TRP A  83
HIS A 114
ASN A 154
TYR A 201
PHE A 299
 None
 0.68A 4yvvA-1qwkA:
40.1		 4yvvA-1qwkA:
39.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		5 / 9 TYR A  52
TRP A  83
HIS A 114
ASN A 154
PHE A 299
 None
 0.71A 4yvvB-1qwkA:
40.0		 4yvvB-1qwkA:
39.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZFC_B_GCZB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		5 / 9 TYR A  52
TRP A  83
HIS A 114
ASN A 154
PHE A 299
 None
 0.74A 4zfcB-1qwkA:
40.2		 4zfcB-1qwkA:
39.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		5 / 10 ALA A  41
PHE A 274
GLY A  20
LEU A  21
ALA A  34
 None
 1.24A 5ajqB-1qwkA:
undetectable		 5ajqB-1qwkA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		3 / 3 THR A  23
HIS A 172
LEU A 112
 None
 0.87A 5axdC-1qwkA:
undetectable		 5axdC-1qwkA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 7 TYR A 111
GLY A  95
SER A  99
LEU A 100
 None
 1.02A 5bphB-1qwkA:
undetectable		 5bphB-1qwkA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 5 THR A  48
ALA A  49
THR A  80
TYR A 111
 None
 1.08A 5ecmA-1qwkA:
undetectable		 5ecmA-1qwkA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 6 THR A  48
ALA A  49
THR A  80
TYR A 111
 None
 1.02A 5ecoA-1qwkA:
1.6		 5ecoA-1qwkA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		5 / 12 ILE A 260
ALA A 259
GLY A  20
LEU A  45
VAL A 276
 None
 1.20A 5i75A-1qwkA:
undetectable		 5i75A-1qwkA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		3 / 3 LEU A  87
TYR A 111
SER A  50
 None
 0.83A 5iktA-1qwkA:
undetectable		 5iktA-1qwkA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 8 SER A 197
GLN A 175
MET A  16
THR A  79
 None
 1.30A 5u6nA-1qwkA:
2.3		 5u6nA-1qwkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_B_SALB504_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 6 SER A 197
GLN A 175
MET A  16
THR A  79
 None
 1.33A 5u6nB-1qwkA:
2.7		 5u6nB-1qwkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 7 VAL A 171
TRP A 135
PHE A 138
GLU A 132
 None
 1.33A 5unxA-1qwkA:
undetectable
5unxB-1qwkA:
undetectable		 5unxA-1qwkA:
21.76
5unxB-1qwkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 7 VAL A 171
TRP A 135
PHE A 138
GLU A 132
 None
 1.34A 5unyA-1qwkA:
undetectable
5unyB-1qwkA:
undetectable		 5unyA-1qwkA:
21.76
5unyB-1qwkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 7 VAL A 176
LEU A 168
PHE A 190
LEU A 164
 None
 1.21A 6aycA-1qwkA:
undetectable		 6aycA-1qwkA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 7 VAL A 131
TRP A 155
TRP A 135
GLU A 132
 None
 1.48A 6cifC-1qwkA:
0.0
6cifD-1qwkA:
0.0		 6cifC-1qwkA:
13.51
6cifD-1qwkA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1
(Caenorhabditis
elegans) 		4 / 7 VAL A 131
TRP A 155
TRP A 135
PHE A 138
 None
 1.34A 6cifC-1qwkA:
0.0
6cifD-1qwkA:
0.0		 6cifC-1qwkA:
13.51
6cifD-1qwkA:
13.51