SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		3 / 3 GLU A 116
HIS A 173
HIS A  98
 ZN  A 604 (-2.7A)
ZN  A 604 (-3.7A)
ZN  A 604 (-3.7A)
 0.60A 1oe2A-1qwrA:
0.0		 1oe2A-1qwrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		5 / 12 GLY A  19
ILE A  16
ASP A 201
SER A 202
PHE A  12
 None
 0.95A 1ri4A-1qwrA:
undetectable		 1ri4A-1qwrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		4 / 7 THR A   2
ALA A  52
ASN A  53
LEU A   8
 None
 1.20A 2hzqA-1qwrA:
undetectable		 2hzqA-1qwrA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		4 / 6 LEU A  87
HIS A 173
GLU A 116
HIS A  98
 None
ZN  A 604 (-3.7A)
ZN  A 604 (-2.7A)
ZN  A 604 (-3.7A)
 0.90A 2ow9A-1qwrA:
undetectable		 2ow9A-1qwrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		4 / 6 ALA A 179
LEU A 180
ALA A  21
THR A  20
 None
FMT  A 606 ( 4.4A)
FMT  A 606 ( 4.6A)
None
 0.85A 3b6hA-1qwrA:
undetectable		 3b6hA-1qwrA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		4 / 6 ALA A 179
LEU A 180
ALA A  21
THR A  20
 None
FMT  A 606 ( 4.4A)
FMT  A 606 ( 4.6A)
None
 0.88A 3b6hB-1qwrA:
undetectable		 3b6hB-1qwrA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		4 / 5 LEU A  87
HIS A 173
GLU A 116
HIS A  98
 None
ZN  A 604 (-3.7A)
ZN  A 604 (-2.7A)
ZN  A 604 (-3.7A)
 0.93A 3kecA-1qwrA:
undetectable		 3kecA-1qwrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		4 / 7 LEU A 153
LEU A 172
SER A  94
THR A 191
 None
None
SO4  A 601 (-2.6A)
SO4  A 601 ( 4.5A)
 1.00A 3lm8B-1qwrA:
2.5
3lm8D-1qwrA:
3.2		 3lm8B-1qwrA:
21.85
3lm8D-1qwrA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		3 / 3 GLN A 185
THR A 184
LEU A   8
 None
 0.67A 3ondA-1qwrA:
undetectable		 3ondA-1qwrA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		3 / 3 GLN A 185
THR A 184
LEU A   8
 None
 0.66A 3ondB-1qwrA:
undetectable		 3ondB-1qwrA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		5 / 10 ASP A  88
VAL A 181
GLY A 178
ALA A 179
ALA A 127
 None
None
FMT  A 606 ( 4.6A)
None
None
 1.21A 3ucjA-1qwrA:
undetectable		 3ucjA-1qwrA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		5 / 10 ASP A  88
VAL A 181
GLY A 178
ALA A 179
ALA A 127
 None
None
FMT  A 606 ( 4.6A)
None
None
 1.22A 3ucjB-1qwrA:
undetectable		 3ucjB-1qwrA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		4 / 6 LEU A  87
HIS A 173
GLU A 116
HIS A  98
 None
ZN  A 604 (-3.7A)
ZN  A 604 (-2.7A)
ZN  A 604 (-3.7A)
 0.91A 4a7bA-1qwrA:
undetectable		 4a7bA-1qwrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		4 / 5 LEU A  87
HIS A 173
GLU A 116
HIS A  98
 None
ZN  A 604 (-3.7A)
ZN  A 604 (-2.7A)
ZN  A 604 (-3.7A)
 0.87A 4a7bB-1qwrA:
undetectable		 4a7bB-1qwrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		3 / 3 GLU A 282
TYR A 281
SER A   4
 None
 0.94A 4at0A-1qwrA:
undetectable		 4at0A-1qwrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		3 / 3 CYH A 286
ASN A  53
LYS A 284
 None
 1.37A 4k50A-1qwrA:
undetectable		 4k50A-1qwrA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		3 / 3 GLY A 170
GLU A 116
THR A 115
 None
ZN  A 604 (-2.7A)
None
 0.58A 4kouA-1qwrA:
0.0		 4kouA-1qwrA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		3 / 3 ARG A 207
GLU A  37
ARG A 199
 SO4  A 601 (-3.1A)
None
None
 0.85A 4mwvA-1qwrA:
undetectable		 4mwvA-1qwrA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		4 / 5 GLU A 109
GLU A 108
TYR A 103
GLU A 106
 None
 1.36A 4r87E-1qwrA:
0.0		 4r87E-1qwrA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		4 / 6 VAL A 313
TYR A 251
GLN A 263
HIS A 315
 None
 1.30A 5kkzA-1qwrA:
undetectable
5kkzG-1qwrA:
0.2		 5kkzA-1qwrA:
20.00
5kkzG-1qwrA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		4 / 7 HIS A 315
VAL A 313
TYR A 251
GLN A 263
 None
 1.27A 5kkzM-1qwrA:
0.0
5kkzO-1qwrA:
undetectable		 5kkzM-1qwrA:
21.70
5kkzO-1qwrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		4 / 7 TYR A 131
ILE A 157
ILE A 129
ILE A 120
 None
 0.89A 5murB-1qwrA:
0.0		 5murB-1qwrA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		5 / 10 ILE A 295
LEU A  61
GLY A  73
ALA A 298
PHE A 267
 None
 1.15A 5mxbA-1qwrA:
undetectable		 5mxbA-1qwrA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		4 / 6 ILE A   6
LEU A  82
PHE A  80
PHE A 242
 None
 1.07A 5vkqA-1qwrA:
0.0
5vkqB-1qwrA:
0.0		 5vkqA-1qwrA:
10.83
5vkqB-1qwrA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		4 / 6 PHE A 242
ILE A   6
LEU A  82
PHE A  80
 None
 1.06A 5vkqA-1qwrA:
0.0
5vkqD-1qwrA:
0.0		 5vkqA-1qwrA:
10.83
5vkqD-1qwrA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		5 / 12 LEU A 288
ILE A 255
HIS A 293
LEU A  86
TYR A  28
 None
 1.36A 5ycpA-1qwrA:
undetectable		 5ycpA-1qwrA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1qwr MANNOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
subtilis) 		3 / 3 TYR A 247
LEU A 112
ASP A  78
 None
 0.89A 5zv2B-1qwrA:
undetectable		 5zv2B-1qwrA:
14.47