SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
ASP A 214
HIS A 293
TYR A 204
 None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
None
 1.28A 1t69A-1qwyA:
undetectable		 1t69A-1qwyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
GLY A 241
ASP A 214
HIS A 293
 None
None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
 1.20A 1t69A-1qwyA:
undetectable		 1t69A-1qwyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 11 HIS A 291
HIS A 260
ASP A 214
HIS A 293
TYR A 204
 None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
None
 1.23A 1zz1A-1qwyA:
undetectable		 1zz1A-1qwyA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_D_SHHD2752_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 9 HIS A 291
HIS A 260
ASP A 214
HIS A 293
TYR A 204
 None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
None
 1.22A 1zz1D-1qwyA:
undetectable		 1zz1D-1qwyA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 THR A 121
SER A 237
GLY A 242
VAL A 232
ILE A 247
 None
 1.02A 2b25B-1qwyA:
undetectable		 2b25B-1qwyA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 HIS A 293
HIS A 260
HIS A 291
 ZN  A 400 (-3.1A)
None
None
 0.73A 3ag4A-1qwyA:
undetectable		 3ag4A-1qwyA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 HIS A 293
HIS A 260
HIS A 291
 ZN  A 400 (-3.1A)
None
None
 0.76A 3ag4N-1qwyA:
undetectable		 3ag4N-1qwyA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		4 / 5 HIS A 291
HIS A 260
ASP A 214
HIS A 293
 None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
 0.89A 3c0zA-1qwyA:
undetectable		 3c0zA-1qwyA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		4 / 6 HIS A 291
HIS A 260
ASP A 214
HIS A 293
 None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
 0.90A 3c0zC-1qwyA:
undetectable		 3c0zC-1qwyA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		4 / 8 GLY A  65
ILE A  53
PHE A  81
PHE A  91
 None
 0.92A 3ko0K-1qwyA:
undetectable
3ko0S-1qwyA:
undetectable		 3ko0K-1qwyA:
11.34
3ko0S-1qwyA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		4 / 7 ASN A  93
GLN A 106
TYR A  90
PRO A  63
 None
 1.28A 3ugrA-1qwyA:
undetectable		 3ugrA-1qwyA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		4 / 4 SER A 146
ASP A 116
ASP A 214
ALA A 209
 None
None
ZN  A 400 (-2.2A)
None
 1.22A 3uj6A-1qwyA:
undetectable		 3uj6A-1qwyA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 GLY A 242
THR A 284
ASN A 261
 None
 0.70A 3v4tD-1qwyA:
undetectable		 3v4tD-1qwyA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
GLY A 241
ASP A 214
HIS A 293
 None
None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
 1.23A 4bz6C-1qwyA:
undetectable		 4bz6C-1qwyA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		4 / 6 ALA A 209
ALA A 112
PRO A 111
THR A 113
 None
 0.90A 4dtzA-1qwyA:
undetectable		 4dtzA-1qwyA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 TYR A 258
ILE A 278
LEU A 192
LEU A 226
GLY A 275
 None
 1.18A 4l9qB-1qwyA:
undetectable		 4l9qB-1qwyA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
GLY A 241
ASP A 214
HIS A 293
 None
None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
 1.19A 4lxzA-1qwyA:
undetectable		 4lxzA-1qwyA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
GLY A 241
ASP A 214
HIS A 293
 None
None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
 1.17A 4lxzC-1qwyA:
undetectable		 4lxzC-1qwyA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
GLY A 241
ASP A 214
HIS A 293
 None
None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
 1.30A 4qa0A-1qwyA:
undetectable		 4qa0A-1qwyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
GLY A 241
ASP A 214
HIS A 293
 None
None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
 1.20A 4qa2A-1qwyA:
undetectable		 4qa2A-1qwyA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
GLY A 241
ASP A 214
HIS A 293
 None
None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
 1.24A 4qa2B-1qwyA:
undetectable		 4qa2B-1qwyA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
ASP A 214
HIS A 293
TYR A 204
 None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
None
 1.17A 5eeiA-1qwyA:
undetectable		 5eeiA-1qwyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
GLY A 241
ASP A 214
HIS A 293
 None
None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
 1.25A 5eeiA-1qwyA:
undetectable		 5eeiA-1qwyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
ASP A 214
HIS A 293
TYR A 204
 None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
None
 1.17A 5eeiB-1qwyA:
undetectable		 5eeiB-1qwyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
GLY A 241
ASP A 214
HIS A 293
 None
None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
 1.24A 5eeiB-1qwyA:
undetectable		 5eeiB-1qwyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
ASP A 214
HIS A 293
TYR A 204
 None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
None
 1.15A 5eenA-1qwyA:
undetectable		 5eenA-1qwyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
ASP A 214
HIS A 293
TYR A 204
 None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
None
 1.16A 5eenB-1qwyA:
undetectable		 5eenB-1qwyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 SER A 237
HIS A 291
HIS A 260
ASP A 214
HIS A 293
 None
None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
 1.40A 5eenB-1qwyA:
undetectable		 5eenB-1qwyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
ASP A 214
HIS A 293
TYR A 204
 None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
None
 1.16A 5ef8A-1qwyA:
undetectable		 5ef8A-1qwyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 HIS A 291
HIS A 260
ASP A 214
HIS A 293
TYR A 204
 None
None
ZN  A 400 (-2.2A)
ZN  A 400 (-3.1A)
None
 1.16A 5ef8B-1qwyA:
undetectable		 5ef8B-1qwyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		4 / 9 VAL A 232
THR A 246
ASP A 119
ILE A 301
 None
 1.02A 5lg3I-1qwyA:
0.0		 5lg3I-1qwyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		4 / 7 GLY A 285
GLN A 295
ASP A 119
TYR A 239
 None
 1.12A 5vlmC-1qwyA:
undetectable		 5vlmC-1qwyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		4 / 7 GLY A 285
GLN A 295
ASP A 119
TYR A 239
 None
 1.04A 5vlmG-1qwyA:
undetectable		 5vlmG-1qwyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 TYR A 215
ALA A 189
LEU A 313
 None
 0.65A 6d9kF-1qwyA:
undetectable		 6d9kF-1qwyA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1qwy PEPTIDOGLYCAN
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 VAL A 138
ALA A 122
GLN A 135
 None
 0.69A 6gb9A-1qwyA:
undetectable		 6gb9A-1qwyA:
18.83