SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 5 GLU A 202
THR A 166
HIS A 180
HIS A  76
 CO  A1001 ( 2.5A)
None
None
M2C  A3001 ( 4.5A)
 1.50A 1d4fD-1qxyA:
undetectable		 1d4fD-1qxyA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 10 CYH A  19
THR A 235
THR A 246
PHE A  47
ILE A  15
 None
 1.19A 1i18A-1qxyA:
undetectable
1i18B-1qxyA:
undetectable		 1i18A-1qxyA:
18.99
1i18B-1qxyA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 10 PHE A  47
ILE A  15
CYH A  19
THR A 235
THR A 246
 None
 1.19A 1i18A-1qxyA:
undetectable
1i18B-1qxyA:
undetectable		 1i18A-1qxyA:
18.99
1i18B-1qxyA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 ASP A  40
THR A  36
GLU A  73
 None
 0.82A 1pj7A-1qxyA:
undetectable		 1pj7A-1qxyA:
15.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 7 CYH A  67
HIS A  76
HIS A 175
TRP A 219
 M2C  A3001 ( 4.0A)
M2C  A3001 ( 4.5A)
CO  A1003 ( 3.3A)
None
 0.49A 1yvmA-1qxyA:
35.8		 1yvmA-1qxyA:
34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 ILE A 107
ALA A 230
PHE A 109
ILE A  84
ILE A  92
 None
 1.06A 2bl9A-1qxyA:
undetectable		 2bl9A-1qxyA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 11 ILE A 107
ALA A 230
PHE A 109
ILE A  84
ILE A  92
 None
 1.09A 2blaA-1qxyA:
undetectable		 2blaA-1qxyA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 10 ALA A  96
ALA A 103
THR A 235
MET A   1
VAL A 198
 None
 1.36A 2wuzA-1qxyA:
undetectable		 2wuzA-1qxyA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 10 ALA A  96
ALA A 103
THR A 235
MET A   1
VAL A 198
 None
 1.38A 2wuzB-1qxyA:
0.0		 2wuzB-1qxyA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 SER A  95
ASP A  93
ASP A  59
 M2C  A3001 ( 3.8A)
CO  A1002 ( 1.8A)
None
 0.86A 3iv6C-1qxyA:
undetectable		 3iv6C-1qxyA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 9 ILE A  68
VAL A  90
THR A  30
ILE A  34
ILE A  84
 None
 0.79A 3p4wB-1qxyA:
0.0		 3p4wB-1qxyA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 10 ILE A  68
VAL A  90
THR A  30
ILE A  34
ILE A  84
 None
 0.79A 3p4wD-1qxyA:
undetectable		 3p4wD-1qxyA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 10 ILE A  68
VAL A  90
THR A  30
ILE A  34
ILE A  84
 None
 0.79A 3p4wE-1qxyA:
0.0		 3p4wE-1qxyA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 10 ILE A 107
ALA A 230
PHE A 109
ILE A  84
ILE A  92
 None
 1.02A 3qgtA-1qxyA:
undetectable		 3qgtA-1qxyA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 8 ILE A   2
VAL A 137
LEU A 193
ILE A 146
 None
 0.78A 4r38D-1qxyA:
1.1		 4r38D-1qxyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 11 LEU A  97
ALA A  96
HIS A 234
THR A 246
ILE A 237
 None
 1.11A 4uuuA-1qxyA:
undetectable
4uuuB-1qxyA:
undetectable		 4uuuA-1qxyA:
20.91
4uuuB-1qxyA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 4 LEU A 245
ILE A 201
HIS A 234
VAL A 236
 None
 1.15A 4xyzA-1qxyA:
0.6		 4xyzA-1qxyA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 GLU A  72
LYS A 226
ASN A  71
 None
 1.06A 4y1dA-1qxyA:
undetectable
4y1dD-1qxyA:
undetectable		 4y1dA-1qxyA:
21.32
4y1dD-1qxyA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 6 ARG A  23
ILE A  92
GLN A  27
ILE A 232
 None
 1.20A 4z4dA-1qxyA:
undetectable		 4z4dA-1qxyA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 ILE A 251
ALA A  55
ALA A  96
VAL A  94
LEU A 174
 None
M2C  A3001 ( 4.8A)
None
None
M2C  A3001 (-4.5A)
 1.02A 5igtA-1qxyA:
undetectable		 5igtA-1qxyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 7 GLY A 167
HIS A 168
ASP A 104
HIS A  76
 None
CO  A1001 (-3.3A)
CO  A1002 (-2.4A)
M2C  A3001 ( 4.5A)
 0.86A 5nnwD-1qxyA:
0.0		 5nnwD-1qxyA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 7 GLY A 167
HIS A 168
ASP A 104
HIS A  76
 None
CO  A1001 (-3.3A)
CO  A1002 (-2.4A)
M2C  A3001 ( 4.5A)
 0.86A 5no9D-1qxyA:
0.0		 5no9D-1qxyA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 8 SER A  69
PHE A  62
PHE A 204
VAL A 212
 None
None
M2C  A3001 (-4.7A)
None
 1.10A 5vkqB-1qxyA:
undetectable
5vkqC-1qxyA:
undetectable		 5vkqB-1qxyA:
10.05
5vkqC-1qxyA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 5 PRO A 139
GLY A 140
THR A 141
LYS A 142
 None
 1.04A 5x23A-1qxyA:
0.0		 5x23A-1qxyA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 6 PRO A 139
GLY A 140
THR A 141
LYS A 142
 None
 1.01A 5x24A-1qxyA:
undetectable		 5x24A-1qxyA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 6 PRO A 139
GLY A 140
THR A 141
LYS A 142
 None
 1.00A 5xxiA-1qxyA:
0.0		 5xxiA-1qxyA:
19.06