SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qyc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		4 / 8 LEU A 250
VAL A 272
GLY A 181
GLU A 247
 None
 0.96A 1jlfA-1qycA:
undetectable
1jlfB-1qycA:
undetectable		 1jlfA-1qycA:
21.06
1jlfB-1qycA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		4 / 8 ILE A 146
TYR A 150
ILE A 141
GLU A 142
 None
 0.83A 1mrjA-1qycA:
undetectable		 1mrjA-1qycA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		5 / 12 TYR A 159
GLY A 168
ALA A 165
SER A 163
SER A 263
 None
 1.37A 1nbhA-1qycA:
5.4		 1nbhA-1qycA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		5 / 12 TYR A 159
GLY A 168
ALA A 165
SER A 163
SER A 263
 None
 1.37A 1nbhD-1qycA:
5.0		 1nbhD-1qycA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		5 / 8 ALA A  21
ILE A  82
ILE A 200
GLY A 196
ILE A 195
 None
 1.36A 1sh9A-1qycA:
undetectable		 1sh9A-1qycA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		4 / 6 ILE A  16
GLY A  17
ALA A  12
HIS A  19
 None
 0.98A 1wmqA-1qycA:
0.0		 1wmqA-1qycA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		4 / 6 ILE A  16
GLY A  17
ALA A  12
HIS A  19
 None
 0.98A 1wmqB-1qycA:
undetectable		 1wmqB-1qycA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		4 / 6 ILE A  16
GLY A  17
ALA A  12
HIS A  19
 None
 0.97A 1wpuA-1qycA:
0.0		 1wpuA-1qycA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		4 / 6 ILE A  16
GLY A  17
ALA A  12
HIS A  19
 None
 0.97A 1wpuB-1qycA:
0.0		 1wpuB-1qycA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		4 / 6 ILE A  16
GLY A  17
ALA A  12
HIS A  19
 None
 1.00A 1wrqA-1qycA:
undetectable		 1wrqA-1qycA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		4 / 6 ILE A  16
GLY A  17
ALA A  12
HIS A  19
 None
 1.00A 1wrqB-1qycA:
undetectable		 1wrqB-1qycA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		4 / 8 LEU A 213
SER A 152
LEU A 215
ASP A 117
 None
 1.06A 2j2pA-1qycA:
0.0
2j2pB-1qycA:
0.0		 2j2pA-1qycA:
21.98
2j2pB-1qycA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		5 / 12 SER A 163
LEU A 227
ASN A 225
VAL A 187
ILE A 179
 None
 1.05A 2nnhA-1qycA:
0.0		 2nnhA-1qycA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		3 / 3 VAL A 118
ASP A 119
GLU A 113
 None
 0.70A 2qeuA-1qycA:
undetectable		 2qeuA-1qycA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		3 / 3 VAL A 118
ASP A 119
GLU A 113
 None
 0.69A 2qeuC-1qycA:
undetectable		 2qeuC-1qycA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		5 / 11 SER A 267
GLY A 183
GLY A 181
LEU A 164
SER A 163
 None
 0.85A 2qmmA-1qycA:
2.9
2qmmB-1qycA:
undetectable		 2qmmA-1qycA:
24.92
2qmmB-1qycA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		4 / 8 GLN A 166
SER A 163
TYR A 159
CYH A 155
 None
 1.40A 2xz5A-1qycA:
undetectable
2xz5C-1qycA:
undetectable		 2xz5A-1qycA:
19.44
2xz5C-1qycA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		5 / 12 TYR A 292
GLY A 196
ILE A  16
VAL A 190
THR A 199
 None
 1.06A 3bwcA-1qycA:
5.7		 3bwcA-1qycA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		3 / 3 LEU A 164
GLU A 232
ILE A 235
 None
 0.58A 3czhA-1qycA:
undetectable		 3czhA-1qycA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		4 / 5 ILE A 281
ARG A 138
THR A 212
GLU A 113
 None
 1.46A 3ny4A-1qycA:
0.0		 3ny4A-1qycA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		5 / 10 LEU A 250
GLY A 181
ILE A 270
GLY A 274
VAL A 124
 None
 1.01A 3oxwC-1qycA:
undetectable		 3oxwC-1qycA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		5 / 12 GLY A 168
ALA A 167
ILE A 264
THR A 256
PRO A 257
 None
 1.11A 3s56A-1qycA:
undetectable		 3s56A-1qycA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		4 / 5 SER A 223
GLY A 183
THR A 277
ASP A 182
 None
 1.14A 4eohA-1qycA:
5.3		 4eohA-1qycA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		4 / 7 SER A 112
GLY A  11
ALA A  12
SER A  24
 None
 0.82A 4r1zB-1qycA:
undetectable		 4r1zB-1qycA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		4 / 6 ASN A 154
ASP A 275
PRO A 218
VAL A 188
 None
 1.12A 4yoaA-1qycA:
undetectable		 4yoaA-1qycA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		3 / 3 ARG A 139
TYR A 148
GLU A 142
 None
 0.53A 4zzbE-1qycA:
undetectable		 4zzbE-1qycA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		3 / 3 THR A  31
SER A  24
ASP A 204
 None
 0.84A 5kvaA-1qycA:
6.0		 5kvaA-1qycA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		3 / 3 THR A  31
SER A  24
ASP A 204
 None
 0.85A 5kvaB-1qycA:
5.9		 5kvaB-1qycA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		5 / 12 ILE A 266
VAL A 187
SER A 267
ALA A 127
VAL A 121
 None
 1.16A 5n0oA-1qycA:
3.2		 5n0oA-1qycA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		3 / 3 GLY A 274
ASN A 278
ARG A 216
 None
 0.78A 5w7bD-1qycA:
4.5		 5w7bD-1qycA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		4 / 6 ASN A 278
VAL A 187
LEU A 222
GLN A 276
 None
 1.50A 5xdhA-1qycA:
0.0
5xdhC-1qycA:
0.0		 5xdhA-1qycA:
12.70
5xdhC-1qycA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		5 / 9 THR A  84
GLY A  86
ILE A  90
PHE A 109
ILE A  96
 None
 1.23A 6ebpA-1qycA:
undetectable		 6ebpA-1qycA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		5 / 10 THR A  84
GLY A  86
ILE A  90
PHE A 109
ILE A  96
 None
 1.22A 6ebpB-1qycA:
undetectable		 6ebpB-1qycA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1
(Pinus
taeda) 		5 / 10 THR A  84
GLY A  86
ILE A  90
PHE A 109
ILE A  96
 None
 1.22A 6ebpC-1qycA:
undetectable		 6ebpC-1qycA:
14.05