SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qyd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		4 / 4 ILE A 226
MET A 305
VAL A 200
GLY A 192
 None
 1.24A 1e06B-1qydA:
0.0		 1e06B-1qydA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		5 / 12 GLU A 116
ILE A 145
ILE A 150
ARG A 142
GLU A 146
 None
 1.39A 1ki3A-1qydA:
0.0		 1ki3A-1qydA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		6 / 11 SER A  82
VAL A  80
ILE A 103
LEU A  74
LEU A  64
LEU A  70
 None
 1.26A 2a15A-1qydA:
undetectable		 2a15A-1qydA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		5 / 12 GLU A 116
ILE A 145
ILE A 150
ARG A 142
GLU A 146
 None
 1.18A 2ki5A-1qydA:
0.0		 2ki5A-1qydA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		4 / 8 ILE A  81
PHE A 117
GLY A  12
GLY A  11
 None
 0.84A 2qx4A-1qydA:
7.6
2qx4B-1qydA:
7.8		 2qx4A-1qydA:
22.29
2qx4B-1qydA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		4 / 6 ILE A  81
PHE A 117
GLY A  12
GLY A  11
 None
 0.81A 2qx6A-1qydA:
7.8
2qx6B-1qydA:
5.4		 2qx6A-1qydA:
22.29
2qx6B-1qydA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		4 / 7 PHE A  35
GLU A  38
VAL A  40
VAL A  46
 None
 1.31A 3jx4A-1qydA:
undetectable
3jx4B-1qydA:
undetectable		 3jx4A-1qydA:
21.63
3jx4B-1qydA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		4 / 5 ILE A 286
ARG A 142
THR A 217
GLU A 116
 None
 1.46A 3ny4A-1qydA:
0.0		 3ny4A-1qydA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		5 / 12 VAL A  79
ALA A  85
PHE A 117
VAL A  21
VAL A 155
 None
 1.11A 4ib4A-1qydA:
undetectable		 4ib4A-1qydA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		4 / 8 ARG A 311
VAL A 195
ASP A 198
ASP A 199
 None
 0.82A 4xqgA-1qydA:
9.5		 4xqgA-1qydA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		4 / 8 ARG A 311
VAL A 195
ASP A 198
ASP A 199
 None
 0.82A 4xqgB-1qydA:
9.6		 4xqgB-1qydA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		3 / 3 THR A  31
SER A  24
ASP A 209
 None
 0.82A 5kvaA-1qydA:
7.3		 5kvaA-1qydA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		3 / 3 THR A  31
SER A  24
ASP A 209
 None
 0.83A 5kvaB-1qydA:
7.2		 5kvaB-1qydA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		5 / 12 VAL A  79
ALA A  85
PHE A 117
VAL A  21
VAL A 155
 None
 1.13A 5tudD-1qydA:
undetectable		 5tudD-1qydA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		3 / 3 GLY A 107
THR A 213
PRO A 151
 None
 0.64A 5v5zA-1qydA:
undetectable		 5v5zA-1qydA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		3 / 3 GLN A 242
TRP A 236
VAL A 313
 None
 0.87A 6auuA-1qydA:
undetectable		 6auuA-1qydA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		5 / 9 ASP A 137
PHE A 135
GLY A 131
SER A  90
GLY A  87
 None
 1.33A 6awoA-1qydA:
undetectable		 6awoA-1qydA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE
(Thuja
plicata) 		5 / 9 ASP A 137
PHE A 135
GLY A 131
SER A  90
GLY A  87
 None
 1.33A 6awqA-1qydA:
undetectable		 6awqA-1qydA:
18.13