SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1qz9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		4 / 8 GLY A 352
TYR A 368
HIS A 344
VAL A 333
 None
 0.88A 1dbbH-1qz9A:
undetectable
1dbbL-1qz9A:
undetectable		 1dbbH-1qz9A:
19.70
1dbbL-1qz9A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		4 / 8 SER A  36
HIS A 204
LYS A 227
ARG A 375
 P3G  A 701 ( 2.9A)
PLP  A1227 ( 4.0A)
PLP  A1227 (-1.3A)
CL  A 601 (-3.1A)
 0.88A 1eqbA-1qz9A:
25.6
1eqbB-1qz9A:
26.9		 1eqbA-1qz9A:
24.63
1eqbB-1qz9A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		4 / 8 SER A  36
HIS A 204
LYS A 227
ARG A 375
 P3G  A 701 ( 2.9A)
PLP  A1227 ( 4.0A)
PLP  A1227 (-1.3A)
CL  A 601 (-3.1A)
 0.89A 1eqbA-1qz9A:
25.6
1eqbB-1qz9A:
26.9		 1eqbA-1qz9A:
24.63
1eqbB-1qz9A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		4 / 8 SER A  36
HIS A 204
LYS A 227
ARG A 375
 P3G  A 701 ( 2.9A)
PLP  A1227 ( 4.0A)
PLP  A1227 (-1.3A)
CL  A 601 (-3.1A)
 0.88A 1eqbC-1qz9A:
26.8
1eqbD-1qz9A:
26.8		 1eqbC-1qz9A:
24.63
1eqbD-1qz9A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		4 / 8 SER A  36
HIS A 204
LYS A 227
ARG A 375
 P3G  A 701 ( 2.9A)
PLP  A1227 ( 4.0A)
PLP  A1227 (-1.3A)
CL  A 601 (-3.1A)
 0.89A 1eqbC-1qz9A:
26.8
1eqbD-1qz9A:
26.8		 1eqbC-1qz9A:
24.63
1eqbD-1qz9A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		5 / 11 LEU A  80
ALA A 208
VAL A  91
MET A 303
LEU A 213
 None
 1.26A 1kt7A-1qz9A:
0.0		 1kt7A-1qz9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		3 / 3 THR A  97
LEU A 101
VAL A 104
 PLP  A1227 (-3.8A)
None
None
 0.43A 1mz9E-1qz9A:
undetectable		 1mz9E-1qz9A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		3 / 3 ARG A 375
ASP A 201
ASN A 100
 CL  A 601 (-3.1A)
PLP  A1227 (-2.7A)
None
 0.95A 1nbhD-1qz9A:
2.2		 1nbhD-1qz9A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		4 / 7 SER A  36
HIS A 204
LYS A 227
ARG A 375
 P3G  A 701 ( 2.9A)
PLP  A1227 ( 4.0A)
PLP  A1227 (-1.3A)
CL  A 601 (-3.1A)
 0.85A 2vmyA-1qz9A:
27.2
2vmyB-1qz9A:
27.2		 2vmyA-1qz9A:
23.66
2vmyB-1qz9A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		5 / 11 LEU A 105
VAL A 104
MET A 170
ILE A 199
ALA A 237
 None
 1.22A 2zbzA-1qz9A:
0.0		 2zbzA-1qz9A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		4 / 5 LEU A 306
GLN A 300
THR A 301
THR A 379
 None
 1.23A 2zj0C-1qz9A:
3.5		 2zj0C-1qz9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		4 / 4 LEU A 306
GLN A 300
THR A 301
THR A 379
 None
 1.24A 2zj0D-1qz9A:
undetectable		 2zj0D-1qz9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		4 / 5 LEU A 306
GLN A 300
THR A 301
THR A 379
 None
 1.26A 3ce6B-1qz9A:
undetectable		 3ce6B-1qz9A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		3 / 3 ARG A 369
THR A 124
THR A  97
 P3G  A 701 (-2.5A)
None
PLP  A1227 (-3.8A)
 0.76A 3k2hB-1qz9A:
undetectable		 3k2hB-1qz9A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A 332
VAL A 345
ILE A 360
LEU A 395
VAL A 321
 None
 1.16A 3sp9B-1qz9A:
undetectable		 3sp9B-1qz9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		5 / 11 THR A 124
LEU A 101
THR A  97
LEU A 171
VAL A 174
 None
None
PLP  A1227 (-3.8A)
None
None
 1.18A 3tbgA-1qz9A:
undetectable		 3tbgA-1qz9A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		3 / 3 ASP A  95
TRP A  64
SER A  73
 None
 1.05A 4lrhB-1qz9A:
undetectable		 4lrhB-1qz9A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		3 / 3 ASP A  95
TRP A  64
SER A  73
 None
 1.03A 4lrhF-1qz9A:
0.0		 4lrhF-1qz9A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		6 / 12 ILE A 398
GLY A 396
VAL A 321
PHE A 317
ILE A 360
ALA A 358
 None
 1.45A 5n0sA-1qz9A:
1.7		 5n0sA-1qz9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A 398
GLY A 396
VAL A 321
PHE A 376
ALA A 358
 None
 1.04A 5n0tA-1qz9A:
0.2		 5n0tA-1qz9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A 398
GLY A 396
VAL A 321
PHE A 317
ALA A 358
 None
 1.17A 5n0wA-1qz9A:
undetectable		 5n0wA-1qz9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		6 / 12 ILE A 398
GLY A 396
VAL A 321
PHE A 317
ILE A 360
ALA A 358
 None
 1.43A 5n0wB-1qz9A:
2.0		 5n0wB-1qz9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		6 / 12 ILE A 398
GLY A 396
VAL A 321
PHE A 317
ILE A 360
ALA A 358
 None
 1.43A 5n4iA-1qz9A:
1.8		 5n4iA-1qz9A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A 316
ASP A 315
ILE A 318
LEU A 320
VAL A 388
 None
 0.94A 5twjC-1qz9A:
undetectable		 5twjC-1qz9A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		5 / 11 LEU A 316
ASP A 315
ILE A 318
LEU A 320
VAL A 388
 None
 0.93A 5twjD-1qz9A:
undetectable		 5twjD-1qz9A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		5 / 9 GLY A 294
TYR A 382
VAL A 297
GLY A 231
PRO A  41
 None
 1.21A 5zniA-1qz9A:
undetectable		 5zniA-1qz9A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		3 / 3 TYR A 278
PRO A 252
LEU A 253
 None
 0.88A 6beoA-1qz9A:
undetectable		 6beoA-1qz9A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1qz9 KYNURENINASE
(Pseudomonas
fluorescens) 		4 / 6 GLY A  68
TRP A  69
ALA A 289
LEU A 288
 None
 1.03A 6fosA-1qz9A:
undetectable		 6fosA-1qz9A:
9.89