SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r03'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		4 / 4 ILE A 145
LEU A 148
VAL A 152
ALA A 160
 None
 0.78A 1mz9A-1r03A:
undetectable		 1mz9A-1r03A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		4 / 5 ILE A 145
LEU A 148
VAL A 152
ALA A 160
 None
 0.78A 1mz9C-1r03A:
undetectable		 1mz9C-1r03A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		3 / 3 SER A  36
GLU A  89
ASP A  91
 None
 0.78A 2zthA-1r03A:
undetectable		 2zthA-1r03A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		3 / 3 SER A  36
GLU A  89
ASP A  91
 None
 0.77A 3bwmA-1r03A:
undetectable		 3bwmA-1r03A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		3 / 3 SER A  36
GLU A  89
ASP A  91
 None
 0.77A 3bwyA-1r03A:
undetectable		 3bwyA-1r03A:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		4 / 6 LEU A  28
SER A  31
TYR A  32
LEU A  35
 None
 0.16A 3f33A-1r03A:
27.5		 3f33A-1r03A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		5 / 12 LEU A 133
PHE A 132
SER A  16
ILE A  20
LEU A  69
 None
 1.13A 3ia4C-1r03A:
undetectable		 3ia4C-1r03A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		5 / 12 LEU A 133
PHE A 132
SER A  16
ILE A  20
LEU A  69
 None
 1.14A 3ia4D-1r03A:
undetectable		 3ia4D-1r03A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		5 / 12 TYR A  54
TYR A  34
GLY A  96
MET A  37
LEU A  97
 None
 1.41A 3ou6D-1r03A:
undetectable		 3ou6D-1r03A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		4 / 5 GLU A 107
GLU A 147
TYR A  54
TYR A  34
 None
 1.41A 4twdA-1r03A:
3.6
4twdE-1r03A:
3.5		 4twdA-1r03A:
20.79
4twdE-1r03A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		4 / 5 GLU A 147
GLU A 107
TYR A  34
TYR A  54
 None
 1.31A 4twdA-1r03A:
3.6
4twdE-1r03A:
3.5		 4twdA-1r03A:
20.79
4twdE-1r03A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		4 / 5 TYR A  34
GLU A 107
GLU A 147
TYR A  54
 None
 1.48A 4twdA-1r03A:
3.6
4twdB-1r03A:
3.6		 4twdA-1r03A:
20.79
4twdB-1r03A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		4 / 5 TYR A  54
GLU A 147
GLU A 107
TYR A  34
 None
 1.33A 4twdA-1r03A:
3.6
4twdB-1r03A:
3.6		 4twdA-1r03A:
20.79
4twdB-1r03A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		4 / 6 TYR A  34
GLU A 107
GLU A 147
TYR A  54
 None
 1.46A 4twdG-1r03A:
0.9
4twdH-1r03A:
2.2		 4twdG-1r03A:
20.79
4twdH-1r03A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		4 / 6 TYR A  54
GLU A 147
GLU A 107
TYR A  34
 None
 1.33A 4twdG-1r03A:
0.9
4twdH-1r03A:
2.2		 4twdG-1r03A:
20.79
4twdH-1r03A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens) 		3 / 3 SER A  36
GLU A  89
ASP A  91
 None
 0.73A 4xudA-1r03A:
undetectable		 4xudA-1r03A:
21.97