SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r0d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1r0d HUNTINGTIN
INTERACTING PROTEIN
12
(Homo
sapiens) 		5 / 12 SER A 826
VAL A 949
LEU A 886
MET A 804
GLU A 902
 None
 1.49A 1a27A-1r0dA:
undetectable		 1a27A-1r0dA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1r0d HUNTINGTIN
INTERACTING PROTEIN
12
(Homo
sapiens) 		5 / 9 THR A 914
ALA A 915
LEU A 917
ALA A 919
SER A 921
 None
 1.43A 3kp6B-1r0dA:
1.3		 3kp6B-1r0dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 1r0d HUNTINGTIN
INTERACTING PROTEIN
12
(Homo
sapiens) 		5 / 11 ALA A 890
ILE A 801
LEU A 886
LEU A 830
THR A 828
 None
 1.07A 3kw2B-1r0dA:
undetectable		 3kw2B-1r0dA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1r0d HUNTINGTIN
INTERACTING PROTEIN
12
(Homo
sapiens) 		5 / 9 ALA A 793
THR A 790
ALA A 789
VAL A 887
GLY A 882
 None
 1.23A 4qvnK-1r0dA:
undetectable
4qvnL-1r0dA:
undetectable		 4qvnK-1r0dA:
21.88
4qvnL-1r0dA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1r0d HUNTINGTIN
INTERACTING PROTEIN
12
(Homo
sapiens) 		5 / 9 ALA A 793
THR A 790
ALA A 789
VAL A 887
GLY A 882
 None
 1.23A 4qvnY-1r0dA:
undetectable
4qvnZ-1r0dA:
undetectable		 4qvnY-1r0dA:
21.88
4qvnZ-1r0dA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1r0d HUNTINGTIN
INTERACTING PROTEIN
12
(Homo
sapiens) 		4 / 4 ASN A 948
SER A 955
ALA A 951
VAL A 950
 None
 1.31A 5nm5A-1r0dA:
undetectable		 5nm5A-1r0dA:
20.00