SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r0o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 1r0o ECDYSONE RECEPTOR
(Drosophila
melanogaster) 		4 / 6 CYH B   7
ASP B  12
VAL B   9
GLY B  26
 ZN  B 350 (-2.5A)
None
ZN  B 350 ( 4.8A)
None
 1.03A 1ekjC-1r0oB:
undetectable
1ekjD-1r0oB:
undetectable		 1ekjC-1r0oB:
18.26
1ekjD-1r0oB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 1r0o ECDYSONE RECEPTOR
(Drosophila
melanogaster) 		4 / 6 CYH B   7
ASP B  12
VAL B   9
GLY B  26
 ZN  B 350 (-2.5A)
None
ZN  B 350 ( 4.8A)
None
 1.00A 1ekjC-1r0oB:
undetectable
1ekjD-1r0oB:
undetectable		 1ekjC-1r0oB:
18.26
1ekjD-1r0oB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 1r0o ECDYSONE RECEPTOR
ULTRASPIRACLE
PROTEIN
(Drosophila
melanogaster) 		4 / 6 CYH A  10
ASP A  52
ASP B  52
TYR B  54
 ZN  A 351 (-2.4A)
None
None
None
 1.46A 2todA-1r0oA:
undetectable
2todB-1r0oA:
undetectable		 2todA-1r0oA:
11.78
2todB-1r0oA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_D_DMOD700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 1r0o ECDYSONE RECEPTOR
ULTRASPIRACLE
PROTEIN
(Drosophila
melanogaster) 		4 / 5 ASP B  52
TYR B  54
CYH A  10
ASP A  52
 None
None
ZN  A 351 (-2.4A)
None
 1.44A 2todC-1r0oB:
undetectable
2todD-1r0oB:
undetectable		 2todC-1r0oB:
11.58
2todD-1r0oB:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1r0o ECDYSONE RECEPTOR
ULTRASPIRACLE
PROTEIN
(Drosophila
melanogaster) 		3 / 3 ILE A  50
MET B  53
ARG B  57
 None
 0.78A 4lnwA-1r0oA:
undetectable		 4lnwA-1r0oA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1r0o ECDYSONE RECEPTOR
ULTRASPIRACLE
PROTEIN
(Drosophila
melanogaster) 		3 / 3 ILE A  50
MET B  53
ARG B  57
 None
 0.80A 4lnxA-1r0oA:
undetectable		 4lnxA-1r0oA:
15.47