SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r0v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 1r0v TRNA-INTRON
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		4 / 6 VAL A 121
VAL A 133
ILE A 102
ARG A 280
 None
 1.13A 1iepA-1r0vA:
undetectable		 1iepA-1r0vA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 1r0v TRNA-INTRON
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		4 / 7 LEU A 298
LYS A 110
LEU A  94
ALA A 111
 None
 1.02A 1sn0B-1r0vA:
undetectable
1sn0D-1r0vA:
0.3		 1sn0B-1r0vA:
16.56
1sn0D-1r0vA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 1r0v TRNA-INTRON
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		4 / 7 LYS A 110
LEU A  94
ALA A 111
LEU A 298
 None
 1.03A 1sn0B-1r0vA:
undetectable
1sn0D-1r0vA:
0.3		 1sn0B-1r0vA:
16.56
1sn0D-1r0vA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 1r0v TRNA-INTRON
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		3 / 3 TYR A 130
VAL A  69
THR A 129
 None
 0.82A 2ygnA-1r0vA:
0.0		 2ygnA-1r0vA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1r0v TRNA-INTRON
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		3 / 3 PRO A  95
LEU A  87
ARG A  74
 None
 0.91A 3aqiA-1r0vA:
undetectable		 3aqiA-1r0vA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1r0v TRNA-INTRON
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		3 / 3 TYR A 297
GLU A 259
TYR A 246
 None
 0.74A 3ug8A-1r0vA:
undetectable		 3ug8A-1r0vA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1r0v TRNA-INTRON
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		3 / 3 TYR A 246
ARG A 244
SER A 258
 None
 1.11A 4khpI-1r0vA:
undetectable
4khpJ-1r0vA:
0.0		 4khpI-1r0vA:
18.09
4khpJ-1r0vA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1r0v TRNA-INTRON
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		5 / 9 ALA A 120
VAL A 121
LEU A 272
ILE A 102
ILE A 107
 None
 1.00A 5nunA-1r0vA:
undetectable		 5nunA-1r0vA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1r0v TRNA-INTRON
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		3 / 3 HIS A 257
SER A 258
LYS A 287
 None
 0.78A 5os7A-1r0vA:
0.0		 5os7A-1r0vA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 1r0v TRNA-INTRON
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		5 / 10 ILE A 184
LEU A 190
VAL A 158
LEU A 153
GLU A 204
 None
 1.42A 5tixB-1r0vA:
undetectable		 5tixB-1r0vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1r0v TRNA-INTRON
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		3 / 3 HIS A 257
SER A 258
LYS A 287
 None
 0.78A 6gmdB-1r0vA:
0.0		 6gmdB-1r0vA:
22.61