SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Escherichia
coli) 		3 / 3 ALA B  58
VAL B  60
TRP B  63
 None
 0.84A 1av2C-1r2kB:
undetectable
1av2D-1r2kB:
undetectable		 1av2C-1r2kB:
6.59
1av2D-1r2kB:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Escherichia
coli) 		3 / 3 ALA B  58
VAL B  60
TRP B  63
 None
 0.76A 1nt5A-1r2kB:
undetectable		 1nt5A-1r2kB:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Escherichia
coli) 		3 / 3 ALA B  58
VAL B  60
TRP B  63
 None
 0.76A 1nt5B-1r2kB:
undetectable		 1nt5B-1r2kB:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Escherichia
coli) 		3 / 3 ALA B  58
VAL B  60
TRP B  63
 None
 0.83A 1nt6A-1r2kB:
undetectable		 1nt6A-1r2kB:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Escherichia
coli) 		3 / 3 ALA B  58
VAL B  60
TRP B  63
 None
 0.83A 1nt6B-1r2kB:
undetectable		 1nt6B-1r2kB:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Escherichia
coli) 		3 / 3 ALA B  58
VAL B  60
TRP B  63
 None
 0.85A 1w5uC-1r2kB:
undetectable
1w5uD-1r2kB:
undetectable		 1w5uC-1r2kB:
6.59
1w5uD-1r2kB:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Escherichia
coli) 		3 / 3 TRP B  63
ALA B  58
VAL B  60
 None
 0.81A 2izqA-1r2kB:
undetectable
2izqB-1r2kB:
undetectable		 2izqA-1r2kB:
6.59
2izqB-1r2kB:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Escherichia
coli) 		4 / 6 LEU B  90
LEU B  91
ILE B  56
ARG B  57
 None
 0.99A 2rlfB-1r2kB:
0.0
2rlfC-1r2kB:
0.0		 2rlfB-1r2kB:
15.72
2rlfC-1r2kB:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Escherichia
coli) 		5 / 10 ILE B 150
ILE B 149
VAL B 104
GLY B 100
LEU B 131
 None
 1.32A 3em0A-1r2kB:
undetectable		 3em0A-1r2kB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Escherichia
coli) 		5 / 12 GLY B  76
GLY B  77
VAL B  17
LEU B  32
ILE B  56
 SO4  B 170 ( 3.8A)
SO4  B 170 (-4.1A)
None
None
None
 1.16A 3h52B-1r2kB:
undetectable		 3h52B-1r2kB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Escherichia
coli) 		3 / 3 ALA B  58
VAL B  60
TRP B  63
 None
 0.82A 3l8lA-1r2kB:
undetectable
3l8lB-1r2kB:
undetectable		 3l8lA-1r2kB:
6.59
3l8lB-1r2kB:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Escherichia
coli) 		4 / 6 LEU B  91
PHE B  94
ILE B 132
ALA B 124
 None
 1.02A 3mdrA-1r2kB:
undetectable		 3mdrA-1r2kB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Escherichia
coli) 		3 / 3 ASP B  26
ARG B 143
THR B  16
 None
 0.65A 4i13A-1r2kB:
undetectable		 4i13A-1r2kB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Escherichia
coli) 		3 / 3 ASP B  26
ARG B 143
THR B  16
 None
 0.66A 4p3rA-1r2kB:
undetectable		 4p3rA-1r2kB:
19.44