SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r30'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		6 / 12 TYR A  59
PRO A  61
ARG A 168
LEU A 224
VAL A 225
LEU A 291
 SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SF4  A 401 ( 4.4A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.4A)
DTB  A 502 ( 3.3A)
 1.18A 1r30A-1r30A:
58.6		 1r30A-1r30A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		12 / 12 TYR A  59
PRO A  61
THR A 130
GLY A 132
ASN A 151
ASN A 153
ASP A 155
ARG A 173
ILE A 192
LEU A 224
VAL A 225
LEU A 291
 SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SAM  A 501 ( 4.0A)
SAM  A 501 (-2.7A)
DTB  A 502 (-3.9A)
DTB  A 502 ( 3.7A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.8A)
SAM  A 501 (-4.1A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.4A)
DTB  A 502 ( 3.3A)
 0.05A 1r30A-1r30A:
58.6		 1r30A-1r30A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		6 / 12 TYR A  59
PRO A  61
ARG A 168
LEU A 224
VAL A 225
LEU A 291
 SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SF4  A 401 ( 4.4A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.4A)
DTB  A 502 ( 3.3A)
 1.18A 1r30B-1r30A:
57.5		 1r30B-1r30A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		6 / 12 TYR A  59
PRO A  61
GLY A 132
HIS A 152
ARG A 173
LEU A 232
 SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SAM  A 501 (-2.7A)
SAM  A 501 ( 4.9A)
SAM  A 501 (-3.8A)
None
 1.49A 1r30B-1r30A:
57.5		 1r30B-1r30A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		12 / 12 TYR A  59
PRO A  61
THR A 130
GLY A 132
ASN A 151
HIS A 152
ASN A 153
ARG A 173
ILE A 192
LEU A 224
VAL A 225
LEU A 291
 SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SAM  A 501 ( 4.0A)
SAM  A 501 (-2.7A)
DTB  A 502 (-3.9A)
SAM  A 501 ( 4.9A)
DTB  A 502 ( 3.7A)
SAM  A 501 (-3.8A)
SAM  A 501 (-4.1A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.4A)
DTB  A 502 ( 3.3A)
 0.05A 1r30B-1r30A:
57.5		 1r30B-1r30A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		3 / 3 TRP A 102
THR A 130
TYR A 150
 None
SAM  A 501 ( 4.0A)
None
 1.26A 2a3aB-1r30A:
8.5		 2a3aB-1r30A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		5 / 11 ILE A 165
THR A 133
GLU A  55
HIS A 152
GLU A 172
 None
None
None
SAM  A 501 ( 4.9A)
None
 1.34A 2fn1A-1r30A:
undetectable		 2fn1A-1r30A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		5 / 11 ILE A 165
THR A 133
GLU A  55
HIS A 152
GLU A 172
 None
None
None
SAM  A 501 ( 4.9A)
None
 1.36A 2fn1B-1r30A:
undetectable		 2fn1B-1r30A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 8 SER A 189
LEU A 209
LEU A 205
ASP A 155
 None
None
None
SAM  A 501 (-3.7A)
 0.94A 2j2pA-1r30A:
undetectable
2j2pB-1r30A:
0.0		 2j2pA-1r30A:
20.95
2j2pB-1r30A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 6 LEU A 147
MET A 129
LEU A 131
GLU A 114
 None
 1.21A 2kuhA-1r30A:
undetectable		 2kuhA-1r30A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 7 LEU A   9
VAL A  12
THR A  13
ASP A 201
 None
 0.60A 2qblA-1r30A:
undetectable		 2qblA-1r30A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 7 GLN A 313
ARG A 265
LEU A 302
ASP A 301
 None
 1.06A 2qqcB-1r30A:
undetectable
2qqcC-1r30A:
undetectable		 2qqcB-1r30A:
14.01
2qqcC-1r30A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 7 LEU A 302
ASP A 301
GLN A 313
ARG A 265
 None
 1.03A 2qqcA-1r30A:
undetectable
2qqcF-1r30A:
undetectable		 2qqcA-1r30A:
9.88
2qqcF-1r30A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 7 GLN A 313
ARG A 265
LEU A 302
ASP A 301
 None
 0.95A 2qqcD-1r30A:
undetectable
2qqcE-1r30A:
0.0		 2qqcD-1r30A:
14.01
2qqcE-1r30A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 7 LEU A 302
ASP A 301
GLN A 313
ARG A 265
 None
 1.02A 2qqcG-1r30A:
0.0
2qqcJ-1r30A:
undetectable		 2qqcG-1r30A:
9.88
2qqcJ-1r30A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 7 LEU A 302
ASP A 301
GLN A 313
ARG A 265
 None
 1.04A 2qqcI-1r30A:
undetectable
2qqcL-1r30A:
undetectable		 2qqcI-1r30A:
9.88
2qqcL-1r30A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 8 GLN A 313
ARG A 265
LEU A 302
ASP A 301
 None
 0.74A 2qqcH-1r30A:
undetectable
2qqcK-1r30A:
undetectable		 2qqcH-1r30A:
14.01
2qqcK-1r30A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		5 / 12 SER A 257
MET A 254
GLY A 191
VAL A 193
ILE A 221
 None
 1.34A 3jb2A-1r30A:
0.0		 3jb2A-1r30A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 5 LEU A 291
ALA A 263
PHE A 285
ASN A 153
 DTB  A 502 ( 3.3A)
DTB  A 502 (-3.4A)
DTB  A 502 (-4.5A)
DTB  A 502 ( 3.7A)
 1.40A 3uq6A-1r30A:
2.2		 3uq6A-1r30A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 4 LEU A 291
ALA A 263
PHE A 285
ASN A 153
 DTB  A 502 ( 3.3A)
DTB  A 502 (-3.4A)
DTB  A 502 (-4.5A)
DTB  A 502 ( 3.7A)
 1.45A 3vaqA-1r30A:
2.5		 3vaqA-1r30A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 8 ALA A 210
VAL A 219
PRO A 220
VAL A 187
 None
None
DTB  A 502 ( 4.7A)
None
 0.53A 4jltA-1r30A:
0.0		 4jltA-1r30A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		3 / 3 LEU A 206
LEU A 174
ASN A 153
 None
None
DTB  A 502 ( 3.7A)
 0.72A 4otwA-1r30A:
undetectable		 4otwA-1r30A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A 259
PHE A 305
ILE A 284
PHE A 277
ASN A 282
 None
 1.37A 5hgcA-1r30A:
undetectable		 5hgcA-1r30A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		3 / 3 ARG A 260
PRO A 220
ASN A 153
 FES  A 402 (-2.5A)
DTB  A 502 ( 4.7A)
DTB  A 502 ( 3.7A)
 0.98A 5jwaA-1r30A:
undetectable
5jwaH-1r30A:
undetectable		 5jwaA-1r30A:
20.42
5jwaH-1r30A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		3 / 3 GLY A  99
VAL A 120
MET A 116
 None
 0.64A 5ycpA-1r30A:
undetectable		 5ycpA-1r30A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 8 LYS A 228
GLY A 229
LEU A  70
GLY A  69
 None
 0.81A 6mdqA-1r30A:
undetectable		 6mdqA-1r30A:
12.74